Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280498759> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4280498759 abstract "Abstract The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) that fosters cancer progression. Here, we show that methylmalonic acid (MMA), an aging-increased oncometabolite that is also produced by aggressive cancer cells, activates fibroblasts in the TME, which reciprocally secrete IL-6 loaded extracellular vesicles (EVs) that drive cancer progression, drug resistance and metastasis. The cancer-associated fibroblast (CAF)-released EV cargo is modified as a result of reactive oxygen species (ROS) generation and activation of the canonical and noncanonical TGFβ signaling pathways in CAFs. EV-associated IL-6 functions as a stroma-tumor messenger that activates the JAK/STAT3 and TGFβ signaling pathways in tumor cells and promote an epithelial-to-mesenchymal transition (EMT) and drug resistance in vitro , and metastatic progression in vivo . Our findings reveal the role of MMA in the activation of CAFs to drive metastatic reprogramming, unveiling multiple potential therapeutic avenues to target MMA at the nexus of aging, the tumor microenvironment and metastasis." @default.
- W4280498759 created "2022-05-22" @default.
- W4280498759 creator A5019076582 @default.
- W4280498759 creator A5025799914 @default.
- W4280498759 creator A5026300543 @default.
- W4280498759 creator A5027851702 @default.
- W4280498759 creator A5037161741 @default.
- W4280498759 creator A5037526817 @default.
- W4280498759 creator A5039629265 @default.
- W4280498759 creator A5043531923 @default.
- W4280498759 creator A5044701800 @default.
- W4280498759 creator A5054576280 @default.
- W4280498759 creator A5062847396 @default.
- W4280498759 creator A5068573519 @default.
- W4280498759 creator A5078856085 @default.
- W4280498759 creator A5084499548 @default.
- W4280498759 creator A5084981510 @default.
- W4280498759 creator A5086654755 @default.
- W4280498759 creator A5087483442 @default.
- W4280498759 creator A5087642965 @default.
- W4280498759 date "2022-05-13" @default.
- W4280498759 modified "2023-09-26" @default.
- W4280498759 title "Tumor-produced aging-associated oncometabolite, methylmalonic acid, promotes cancer-associated fibroblast activation to drive metastatic progression" @default.
- W4280498759 doi "https://doi.org/10.21203/rs.3.rs-1643401/v1" @default.
- W4280498759 hasPublicationYear "2022" @default.
- W4280498759 type Work @default.
- W4280498759 citedByCount "0" @default.
- W4280498759 crossrefType "posted-content" @default.
- W4280498759 hasAuthorship W4280498759A5019076582 @default.
- W4280498759 hasAuthorship W4280498759A5025799914 @default.
- W4280498759 hasAuthorship W4280498759A5026300543 @default.
- W4280498759 hasAuthorship W4280498759A5027851702 @default.
- W4280498759 hasAuthorship W4280498759A5037161741 @default.
- W4280498759 hasAuthorship W4280498759A5037526817 @default.
- W4280498759 hasAuthorship W4280498759A5039629265 @default.
- W4280498759 hasAuthorship W4280498759A5043531923 @default.
- W4280498759 hasAuthorship W4280498759A5044701800 @default.
- W4280498759 hasAuthorship W4280498759A5054576280 @default.
- W4280498759 hasAuthorship W4280498759A5062847396 @default.
- W4280498759 hasAuthorship W4280498759A5068573519 @default.
- W4280498759 hasAuthorship W4280498759A5078856085 @default.
- W4280498759 hasAuthorship W4280498759A5084499548 @default.
- W4280498759 hasAuthorship W4280498759A5084981510 @default.
- W4280498759 hasAuthorship W4280498759A5086654755 @default.
- W4280498759 hasAuthorship W4280498759A5087483442 @default.
- W4280498759 hasAuthorship W4280498759A5087642965 @default.
- W4280498759 hasBestOaLocation W42804987591 @default.
- W4280498759 hasConcept C121608353 @default.
- W4280498759 hasConcept C185592680 @default.
- W4280498759 hasConcept C203014093 @default.
- W4280498759 hasConcept C204232928 @default.
- W4280498759 hasConcept C2776107976 @default.
- W4280498759 hasConcept C2779013556 @default.
- W4280498759 hasConcept C2779256057 @default.
- W4280498759 hasConcept C3020616263 @default.
- W4280498759 hasConcept C502942594 @default.
- W4280498759 hasConcept C52124034 @default.
- W4280498759 hasConcept C54355233 @default.
- W4280498759 hasConcept C76419328 @default.
- W4280498759 hasConcept C86803240 @default.
- W4280498759 hasConcept C95444343 @default.
- W4280498759 hasConcept C96232424 @default.
- W4280498759 hasConceptScore W4280498759C121608353 @default.
- W4280498759 hasConceptScore W4280498759C185592680 @default.
- W4280498759 hasConceptScore W4280498759C203014093 @default.
- W4280498759 hasConceptScore W4280498759C204232928 @default.
- W4280498759 hasConceptScore W4280498759C2776107976 @default.
- W4280498759 hasConceptScore W4280498759C2779013556 @default.
- W4280498759 hasConceptScore W4280498759C2779256057 @default.
- W4280498759 hasConceptScore W4280498759C3020616263 @default.
- W4280498759 hasConceptScore W4280498759C502942594 @default.
- W4280498759 hasConceptScore W4280498759C52124034 @default.
- W4280498759 hasConceptScore W4280498759C54355233 @default.
- W4280498759 hasConceptScore W4280498759C76419328 @default.
- W4280498759 hasConceptScore W4280498759C86803240 @default.
- W4280498759 hasConceptScore W4280498759C95444343 @default.
- W4280498759 hasConceptScore W4280498759C96232424 @default.
- W4280498759 hasLocation W42804987591 @default.
- W4280498759 hasLocation W42804987592 @default.
- W4280498759 hasOpenAccess W4280498759 @default.
- W4280498759 hasPrimaryLocation W42804987591 @default.
- W4280498759 hasRelatedWork W2088611209 @default.
- W4280498759 hasRelatedWork W2154708791 @default.
- W4280498759 hasRelatedWork W2337105312 @default.
- W4280498759 hasRelatedWork W2565219986 @default.
- W4280498759 hasRelatedWork W2747503077 @default.
- W4280498759 hasRelatedWork W2768051448 @default.
- W4280498759 hasRelatedWork W2775501278 @default.
- W4280498759 hasRelatedWork W2883081969 @default.
- W4280498759 hasRelatedWork W3213606916 @default.
- W4280498759 hasRelatedWork W4298014494 @default.
- W4280498759 isParatext "false" @default.
- W4280498759 isRetracted "false" @default.
- W4280498759 workType "article" @default.