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- W4280498953 abstract "Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms and the characteristic location on imaging. Histologically, these tumors are characterized by a heterogenous population of cells with multiple genetic mutations and high infiltrative capacity. The most common mutation seen in this group is a lysine to methionine point mutation seen at position 27 (K27M) within histone 3 (H3). Tumors with the H3 K27M mutation, are considered grade 4 and are now categorized within the H3 K27-altered diffuse midline glioma category by World Health Organization classification. Due to its critical location and aggressive nature, DIPG is resistant to the most eradicative treatment and is universally fatal; however, modern advances in the surgical techniques resulting in safe biopsy of the lesion have significantly improved our understanding of this disease at the molecular level. Genomic analysis has shown several mutations that play a role in the pathophysiology of the disease and can be targeted therapeutically. In this review, we will elaborate on DIPG from general aspects and the evolving molecular landscape. We will also review innovative therapeutic options that have been trialed along with new promising treatments on the horizon." @default.
- W4280498953 created "2022-05-22" @default.
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- W4280498953 creator A5058857118 @default.
- W4280498953 date "2022-05-20" @default.
- W4280498953 modified "2023-10-09" @default.
- W4280498953 title "Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials" @default.
- W4280498953 cites W1518511212 @default.
- W4280498953 cites W1541607181 @default.
- W4280498953 cites W1601755300 @default.
- W4280498953 cites W1613292532 @default.
- W4280498953 cites W1638173227 @default.
- W4280498953 cites W1900971264 @default.
- W4280498953 cites W1969798986 @default.
- W4280498953 cites W1982740186 @default.
- W4280498953 cites W1987293747 @default.
- W4280498953 cites W1989297227 @default.
- W4280498953 cites W2003422441 @default.
- W4280498953 cites W2007510910 @default.
- W4280498953 cites W2007881147 @default.
- W4280498953 cites W2008171713 @default.
- W4280498953 cites W2014364284 @default.
- W4280498953 cites W2020272224 @default.
- W4280498953 cites W2022930470 @default.
- W4280498953 cites W2024020239 @default.
- W4280498953 cites W2027576483 @default.
- W4280498953 cites W2028415754 @default.
- W4280498953 cites W2028643362 @default.
- W4280498953 cites W2031080739 @default.
- W4280498953 cites W2041814673 @default.
- W4280498953 cites W2051921450 @default.
- W4280498953 cites W2054694670 @default.
- W4280498953 cites W2056040684 @default.
- W4280498953 cites W2059196679 @default.
- W4280498953 cites W2077400339 @default.
- W4280498953 cites W2084360387 @default.
- W4280498953 cites W2084560384 @default.
- W4280498953 cites W2085951111 @default.
- W4280498953 cites W2100565163 @default.
- W4280498953 cites W2101775250 @default.
- W4280498953 cites W2106343920 @default.
- W4280498953 cites W2114551767 @default.
- W4280498953 cites W2116054551 @default.
- W4280498953 cites W2118750395 @default.
- W4280498953 cites W2126114195 @default.
- W4280498953 cites W2135062838 @default.
- W4280498953 cites W2146357043 @default.
- W4280498953 cites W2150832248 @default.
- W4280498953 cites W2154930876 @default.
- W4280498953 cites W2161360451 @default.
- W4280498953 cites W2172328801 @default.
- W4280498953 cites W2176722357 @default.
- W4280498953 cites W2178859124 @default.
- W4280498953 cites W2236742033 @default.
- W4280498953 cites W2294395959 @default.
- W4280498953 cites W2304205254 @default.
- W4280498953 cites W2346651667 @default.
- W4280498953 cites W2416368103 @default.
- W4280498953 cites W2434245186 @default.
- W4280498953 cites W2462749555 @default.
- W4280498953 cites W2464740767 @default.
- W4280498953 cites W2481941722 @default.
- W4280498953 cites W2493794248 @default.
- W4280498953 cites W2578173341 @default.
- W4280498953 cites W2583297407 @default.
- W4280498953 cites W2593014410 @default.
- W4280498953 cites W2593125811 @default.
- W4280498953 cites W2605499054 @default.
- W4280498953 cites W2606680370 @default.
- W4280498953 cites W2610193187 @default.
- W4280498953 cites W2626114020 @default.
- W4280498953 cites W2736606943 @default.
- W4280498953 cites W2742224451 @default.
- W4280498953 cites W2751187578 @default.
- W4280498953 cites W2765316290 @default.
- W4280498953 cites W2766564649 @default.
- W4280498953 cites W2770363893 @default.
- W4280498953 cites W2771764388 @default.
- W4280498953 cites W2787278337 @default.
- W4280498953 cites W2802016878 @default.
- W4280498953 cites W2802053370 @default.
- W4280498953 cites W2802584573 @default.
- W4280498953 cites W2803040262 @default.
- W4280498953 cites W2806421539 @default.
- W4280498953 cites W2808090012 @default.
- W4280498953 cites W2808897147 @default.
- W4280498953 cites W2889354357 @default.
- W4280498953 cites W2899585879 @default.
- W4280498953 cites W2910164268 @default.
- W4280498953 cites W2917038957 @default.
- W4280498953 cites W2920065511 @default.
- W4280498953 cites W2923032782 @default.
- W4280498953 cites W2933306564 @default.
- W4280498953 cites W2941269422 @default.
- W4280498953 cites W2944721374 @default.