FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280499127> ?p ?o ?g. }

• W4280499127 endingPage "1212" @default.
• W4280499127 startingPage "1204" @default.
• W4280499127 abstract "Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties. The acute and sub-acute toxicity of oral WA was investigated in mice. In the acute toxicity study, up to 2000 mg/kg of WA was well tolerated without any signs of toxicity or death. In the sub-acute toxicity study, mice were orally administered 10, 70 and 500 mg/kg of WA respectively, daily for 28 days. Upon physiological, serum chemistry, hematology and histopathogical examination, no features suggestive of drug-induced toxicity were observed at any dose levels, thereby confirming the No-Observed Adverse Effect Level (NOAEL) to be at least 500 mg/kg. Furthermore, the oral bioavailability of WA was evaluated using single intravenous and oral doses of 10 mg/kg and 70 mg/kg respectively using sparse sampling strategy. Bioanalysis was carried out using a validated LC-MS/MS method. The AUC of WA was found to be 3996.9 ± 557.6 ng/mL*h and 141.7 ± 16.8 ng/mL*h for the intravenous and oral routes of administration respectively. The oral bioavailability was determined to be 1.8%. To conclude, WA was found to be extremely safe even at high doses, with a low oral bioavailability." @default.
• W4280499127 created "2022-05-22" @default.
• W4280499127 creator A5012577035 @default.
• W4280499127 creator A5013108648 @default.
• W4280499127 creator A5034596765 @default.
• W4280499127 creator A5040085413 @default.
• W4280499127 creator A5044346237 @default.
• W4280499127 creator A5074785281 @default.
• W4280499127 creator A5079942978 @default.
• W4280499127 creator A5087013634 @default.
• W4280499127 creator A5088151142 @default.
• W4280499127 date "2022-01-01" @default.
• W4280499127 modified "2023-10-02" @default.
• W4280499127 title "Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice" @default.
• W4280499127 cites W1719692797 @default.
• W4280499127 cites W1813720669 @default.
• W4280499127 cites W1968602545 @default.
• W4280499127 cites W1991886580 @default.
• W4280499127 cites W1992081379 @default.
• W4280499127 cites W2008442012 @default.
• W4280499127 cites W2009158341 @default.
• W4280499127 cites W2038640565 @default.
• W4280499127 cites W2053504140 @default.
• W4280499127 cites W2149346046 @default.
• W4280499127 cites W2168863220 @default.
• W4280499127 cites W2183943753 @default.
• W4280499127 cites W2291906260 @default.
• W4280499127 cites W2399063607 @default.
• W4280499127 cites W2503699902 @default.
• W4280499127 cites W2745022747 @default.
• W4280499127 cites W2883844768 @default.
• W4280499127 cites W2885046266 @default.
• W4280499127 cites W2887552673 @default.
• W4280499127 cites W2898357808 @default.
• W4280499127 cites W2905633101 @default.
• W4280499127 cites W2923149243 @default.
• W4280499127 cites W2944614868 @default.
• W4280499127 cites W2968471757 @default.
• W4280499127 cites W2981687953 @default.
• W4280499127 cites W3024529949 @default.
• W4280499127 cites W3042915152 @default.
• W4280499127 cites W3128029717 @default.
• W4280499127 cites W3172540966 @default.
• W4280499127 cites W4213454682 @default.
• W4280499127 doi "https://doi.org/10.1016/j.toxrep.2022.05.012" @default.
• W4280499127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36518386" @default.
• W4280499127 hasPublicationYear "2022" @default.
• W4280499127 type Work @default.
• W4280499127 citedByCount "5" @default.
• W4280499127 countsByYear W42804991272023 @default.
• W4280499127 crossrefType "journal-article" @default.
• W4280499127 hasAuthorship W4280499127A5012577035 @default.
• W4280499127 hasAuthorship W4280499127A5013108648 @default.
• W4280499127 hasAuthorship W4280499127A5034596765 @default.
• W4280499127 hasAuthorship W4280499127A5040085413 @default.
• W4280499127 hasAuthorship W4280499127A5044346237 @default.
• W4280499127 hasAuthorship W4280499127A5074785281 @default.
• W4280499127 hasAuthorship W4280499127A5079942978 @default.
• W4280499127 hasAuthorship W4280499127A5087013634 @default.
• W4280499127 hasAuthorship W4280499127A5088151142 @default.
• W4280499127 hasBestOaLocation W42804991271 @default.
• W4280499127 hasConcept C112705442 @default.
• W4280499127 hasConcept C116263406 @default.
• W4280499127 hasConcept C126322002 @default.
• W4280499127 hasConcept C142724271 @default.
• W4280499127 hasConcept C181389837 @default.
• W4280499127 hasConcept C185592680 @default.
• W4280499127 hasConcept C204787440 @default.
• W4280499127 hasConcept C2776598214 @default.
• W4280499127 hasConcept C2777056448 @default.
• W4280499127 hasConcept C2780069950 @default.
• W4280499127 hasConcept C29730261 @default.
• W4280499127 hasConcept C42404028 @default.
• W4280499127 hasConcept C71924100 @default.
• W4280499127 hasConcept C98274493 @default.
• W4280499127 hasConceptScore W4280499127C112705442 @default.
• W4280499127 hasConceptScore W4280499127C116263406 @default.
• W4280499127 hasConceptScore W4280499127C126322002 @default.
• W4280499127 hasConceptScore W4280499127C142724271 @default.
• W4280499127 hasConceptScore W4280499127C181389837 @default.
• W4280499127 hasConceptScore W4280499127C185592680 @default.
• W4280499127 hasConceptScore W4280499127C204787440 @default.
• W4280499127 hasConceptScore W4280499127C2776598214 @default.
• W4280499127 hasConceptScore W4280499127C2777056448 @default.
• W4280499127 hasConceptScore W4280499127C2780069950 @default.
• W4280499127 hasConceptScore W4280499127C29730261 @default.
• W4280499127 hasConceptScore W4280499127C42404028 @default.
• W4280499127 hasConceptScore W4280499127C71924100 @default.
• W4280499127 hasConceptScore W4280499127C98274493 @default.
• W4280499127 hasFunder F4320335498 @default.
• W4280499127 hasFunder F4320338100 @default.
• W4280499127 hasLocation W42804991271 @default.
• W4280499127 hasLocation W42804991272 @default.
• W4280499127 hasLocation W42804991273 @default.
• W4280499127 hasLocation W42804991274 @default.
• W4280499127 hasOpenAccess W4280499127 @default.
• W4280499127 hasPrimaryLocation W42804991271 @default.
• W4280499127 hasRelatedWork W1970331292 @default.

• next