FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280499455> ?p ?o ?g. }

• W4280499455 endingPage "s80" @default.
• W4280499455 startingPage "s80" @default.
• W4280499455 abstract "Background: Transmission of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) is of special concern among frail patients in nursing homes. To understand environmental contamination patterns in this setting, we screened a suitable section of a nursing home over time and assessed MRSA and VRE prevalence in patients and their rooms. We were especially interested in assessing whether MRSA and VRE strains persist in rooms during changes of occupancy after patient discharge. Methods: We conducted a prospective cohort study of MRSA and VRE colonization and contamination among successive patients in a cluster of 9 single-occupancy rooms. Using flocked swabs, 5 high-touch surfaces were screened 3 times a week for 34 weeks. Patients were also screened (ie, nares, groin, and hands), if they agreed to participate. Whole-genome sequencing was performed on 67 nonredundant MRSA and VRE strains. Single-nucleotide polymorphism heatmaps and similarity trees were generated to evaluate strain diversity and persistence the facility. Results: Overall, 146 distinct occupancy events were captured during the study (16.5 average per room; range, 11–22), with 387 study visits and 4,670 total swabs collected. All rooms were contaminated with VRE, and 8 of 9 were contaminated with MRSA at least once during the study period. New contamination of a room with MRSA or VRE was observed in 43 (23%) of 185 opportunities, with potential persistence during occupancy changes in 25 (32.9%) of 76 opportunities. Sequencing of 67 nonredundant isolates identified at least 6 enterococcal clades and 10 MRSA clades (6 USA100 and 4 USA300), indicating a high degree of diversity and probably multiple introductions in the facility during the study time. In 3 separate cases, whole-genome sequencing confirmed persistence of a specific MRSA strain during a change of room occupancy, including 1 case of a MRSA strain persisting in a clean room before admission of the next patient. For VRE, 2 cases of persistence during room occupancy changes were confirmed, along with 6 cases of possible persistence (contamination across noncontiguous room occupancy events). Conclusions: Active surveillance screening and a recurring evaluation of terminal cleaning procedures should be considered due to high levels of circulation and persistence of MRSA and VRE in the nursing home setting. Funding: None Disclosures: None" @default.
• W4280499455 created "2022-05-22" @default.
• W4280499455 creator A5003211123 @default.
• W4280499455 creator A5007001251 @default.
• W4280499455 creator A5013445381 @default.
• W4280499455 creator A5037407036 @default.
• W4280499455 creator A5064206456 @default.
• W4280499455 creator A5068311676 @default.
• W4280499455 creator A5088293137 @default.
• W4280499455 date "2022-05-16" @default.
• W4280499455 modified "2023-10-18" @default.
• W4280499455 title "Diversity and persistence of MRSA and VRE in nursing homes: Environmental screening and whole-genome sequencing" @default.
• W4280499455 doi "https://doi.org/10.1017/ash.2022.208" @default.
• W4280499455 hasPublicationYear "2022" @default.
• W4280499455 type Work @default.
• W4280499455 citedByCount "0" @default.
• W4280499455 crossrefType "journal-article" @default.
• W4280499455 hasAuthorship W4280499455A5003211123 @default.
• W4280499455 hasAuthorship W4280499455A5007001251 @default.
• W4280499455 hasAuthorship W4280499455A5013445381 @default.
• W4280499455 hasAuthorship W4280499455A5037407036 @default.
• W4280499455 hasAuthorship W4280499455A5064206456 @default.
• W4280499455 hasAuthorship W4280499455A5068311676 @default.
• W4280499455 hasAuthorship W4280499455A5088293137 @default.
• W4280499455 hasBestOaLocation W42804994551 @default.
• W4280499455 hasConcept C119599485 @default.
• W4280499455 hasConcept C127413603 @default.
• W4280499455 hasConcept C187320778 @default.
• W4280499455 hasConcept C2777052132 @default.
• W4280499455 hasConcept C2779489039 @default.
• W4280499455 hasConcept C2781009140 @default.
• W4280499455 hasConcept C42972112 @default.
• W4280499455 hasConcept C523546767 @default.
• W4280499455 hasConcept C54355233 @default.
• W4280499455 hasConcept C71924100 @default.
• W4280499455 hasConcept C761482 @default.
• W4280499455 hasConcept C86803240 @default.
• W4280499455 hasConceptScore W4280499455C119599485 @default.
• W4280499455 hasConceptScore W4280499455C127413603 @default.
• W4280499455 hasConceptScore W4280499455C187320778 @default.
• W4280499455 hasConceptScore W4280499455C2777052132 @default.
• W4280499455 hasConceptScore W4280499455C2779489039 @default.
• W4280499455 hasConceptScore W4280499455C2781009140 @default.
• W4280499455 hasConceptScore W4280499455C42972112 @default.
• W4280499455 hasConceptScore W4280499455C523546767 @default.
• W4280499455 hasConceptScore W4280499455C54355233 @default.
• W4280499455 hasConceptScore W4280499455C71924100 @default.
• W4280499455 hasConceptScore W4280499455C761482 @default.
• W4280499455 hasConceptScore W4280499455C86803240 @default.
• W4280499455 hasIssue "S1" @default.
• W4280499455 hasLocation W42804994551 @default.
• W4280499455 hasLocation W42804994552 @default.
• W4280499455 hasOpenAccess W4280499455 @default.
• W4280499455 hasPrimaryLocation W42804994551 @default.
• W4280499455 hasRelatedWork W184482454 @default.
• W4280499455 hasRelatedWork W1994007191 @default.
• W4280499455 hasRelatedWork W2070709993 @default.
• W4280499455 hasRelatedWork W2117391666 @default.
• W4280499455 hasRelatedWork W2996418163 @default.
• W4280499455 hasRelatedWork W3007351872 @default.
• W4280499455 hasRelatedWork W3092485492 @default.
• W4280499455 hasRelatedWork W3178918572 @default.
• W4280499455 hasRelatedWork W4200148808 @default.
• W4280499455 hasRelatedWork W4281651537 @default.
• W4280499455 hasVolume "2" @default.
• W4280499455 isParatext "false" @default.
• W4280499455 isRetracted "false" @default.
• W4280499455 workType "article" @default.