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- W4280499843 abstract "Reactive cytopenias are a frequent cause for bone marrow investigations, including bone marrow trephine biopsies, especially if clinical examination and laboratory analyses (e.g., detection of substrate deficiencies) cannot provide a sufficient explanation. The evaluation of such biopsies is primarily concerned with the exclusion of diseases that displace the normal hematopoiesis (infiltrates of acute leukemias or lymphomas and metastases), the exclusion of a myelodysplastic syndrome that classically results in ineffective hematopoiesis, or the detection of specific diseases, particularly infectious or histiocytic diseases (e.g., hemophagocytic lymphohistiocytosis).In this review, we describe characteristic morphologic changes of reactive cytopenias, focus on specific infectious and noninfectious clinical pictures, and distinguish them from malignant changes, especially myelodysplastic syndrome and underlying leukemia of large granular T lymphocytes. Drug-induced changes in hematopoiesis are described in another article in this issue.Reaktive Zytopenien sind eine häufige Ursache für Knochenmarkuntersuchungen einschließlich Biopsieentnahmen, insbesondere falls klinische Abklärungen und Laboranalysen (z. B. Feststellung von Substratmängeln) nicht für eine Erklärung sorgen können. Bei der Beurteilung solcher Biopsien geht es in erster Linie um den Ausschluss von Krankheiten, die die normale Hämatopoese verdrängen (Infiltrate akuter Leukämien oder Lymphome, Metastasen), um ein myelodysplastisches Syndrom zu falsifizieren, das klassischerweise zu einer ineffektiven Hämatopoese führt, oder um den Nachweis spezifischer, insbesondere infektiöser oder histiozytärer Krankheiten zu erbringen (z. B. hämophagozytierende Lymphohistiozytose).In dieser Übersicht beschreiben wir charakteristische morphologische Veränderungen reaktiver Zytopenien, fokussieren auf spezifische infektiöse und nichtinfektiöse Krankheitsbilder und grenzen sie von malignen Veränderungen, insbesondere dem myelodysplastischen Syndrom und zugrunde liegender Leukämie grossgranulärer T‑Lymphozyten, ab. Medikamenteninduzierte Veränderungen der Hämatopoese werden in einem anderen Beitrag dieser Ausgabe beschrieben." @default.
- W4280499843 created "2022-05-22" @default.
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- W4280499843 date "2022-05-19" @default.
- W4280499843 modified "2023-10-18" @default.
- W4280499843 title "Differenzialdiagnose reaktiver Zytopenien" @default.
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- W4280499843 doi "https://doi.org/10.1007/s00292-022-01076-2" @default.
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