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- W4280500325 abstract "炎症性肠病(IBD)是一组慢性、复发性肠道炎症, 主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。IBD的发病机制很复杂, 其潜在机制仍不清楚。近年来, 人们对长链非编码RNA(lncRNA)进行了研究, 并将其确定为IBD的潜在生物标志物。在本研究中, 通过使用高通量RNA测序筛选出一种新的lncRNA—lnc78583。前期荧光定量聚合酶链式反应(qRT-PCR)分析结果表明, lnc78583和同源框B13(HOXB13)的mRNA表达水平在IBD患者和炎症状态下的人结直肠黏膜上皮细胞(FHC)中显著降低。为了探索lnc78583在肠道炎症环境中的作用机制, 我们通过对FHC进行lnc78583过表达处理, 发现不仅增加了HOXB13和IL-10的表达, 而且增强了细胞活力, 降低了LDH的释放和p-NF-κB的激活。随后, 我们用人脐带间充质干细胞来源的外泌体(hucMSC-Ex)处理FHC, 结果表明其上调了lnc78583和HOXB13的表达。此外, 进一步预测到miR3202在FHC中和lnc78583以及HOXB13呈负相关作用。lnc78583的过表达下调miR3202, 而miR3202 模拟物显着降低HOXB13的表达水平。综上, 我们的研究初步证明hucMSC-Ex通过lnc78583介导的miR3202/HOXB13通路调节IBD的炎症进程, 从而为IBD提供新的诊断方案和治疗策略。" @default.
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- W4280500325 date "2022-05-01" @default.
- W4280500325 modified "2023-10-12" @default.
- W4280500325 title "HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway" @default.
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- W4280500325 doi "https://doi.org/10.1631/jzus.b2100793" @default.
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