FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280503353> ?p ?o ?g. }

• W4280503353 endingPage "3512" @default.
• W4280503353 startingPage "3498" @default.
• W4280503353 abstract "Helicobacter pylori (H. pylori), creating a global infection rate over 50%, presents great challenges in clinical therapies due to its complex pathological microenvironment in vivo. To improve the eradication efficacy, herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG, calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer. RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H. pylori infection sites, and then effectively destroyed the architecture of H. pylori biofilms, killed dispersed H. pylori and inhibited the re-adhesion of residual bacteria (called biofilms eradication tetralogy). Moreover, RHL/Cl-Ch-cal activated the host immune response to H. pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells. Finally, RHL/Cl-Ch-cal killed the intracellular H. pylori through recovering the lysosomal acidification and assisting degradation. In experiments, RHL/Cl-Ch-cal demonstrated prominent anti-H. pylori efficacy in the classical H. pylori-infected mice model. Therefore, the study provides a comprehensive attack strategy for anti-H. pylori therapies including biofilms eradication tetralogy, immune activation and intracellular bacteria killing." @default.
• W4280503353 created "2022-05-22" @default.
• W4280503353 creator A5020420071 @default.
• W4280503353 creator A5038669556 @default.
• W4280503353 creator A5045954240 @default.
• W4280503353 creator A5048843008 @default.
• W4280503353 creator A5051557196 @default.
• W4280503353 creator A5066153198 @default.
• W4280503353 creator A5066557197 @default.
• W4280503353 creator A5071490696 @default.
• W4280503353 creator A5091531162 @default.
• W4280503353 date "2022-09-01" @default.
• W4280503353 modified "2023-10-14" @default.
• W4280503353 title "Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment" @default.
• W4280503353 cites W1556376361 @default.
• W4280503353 cites W1945796226 @default.
• W4280503353 cites W1970374612 @default.
• W4280503353 cites W1975732734 @default.
• W4280503353 cites W1981915387 @default.
• W4280503353 cites W1989586375 @default.
• W4280503353 cites W1989804346 @default.
• W4280503353 cites W1995186148 @default.
• W4280503353 cites W2022793196 @default.
• W4280503353 cites W2060653523 @default.
• W4280503353 cites W2063199331 @default.
• W4280503353 cites W2064401560 @default.
• W4280503353 cites W2070300719 @default.
• W4280503353 cites W2081513812 @default.
• W4280503353 cites W2084376280 @default.
• W4280503353 cites W2157120247 @default.
• W4280503353 cites W2165679020 @default.
• W4280503353 cites W2183647385 @default.
• W4280503353 cites W2183787411 @default.
• W4280503353 cites W2476984584 @default.
• W4280503353 cites W2550829198 @default.
• W4280503353 cites W2600121819 @default.
• W4280503353 cites W2608178048 @default.
• W4280503353 cites W2609752905 @default.
• W4280503353 cites W2620522542 @default.
• W4280503353 cites W2783198158 @default.
• W4280503353 cites W2809671428 @default.
• W4280503353 cites W2884432856 @default.
• W4280503353 cites W2910216478 @default.
• W4280503353 cites W2919648024 @default.
• W4280503353 cites W2976405046 @default.
• W4280503353 cites W2997537536 @default.
• W4280503353 cites W3009363829 @default.
• W4280503353 cites W3085561260 @default.
• W4280503353 cites W3147698811 @default.
• W4280503353 cites W3167939017 @default.
• W4280503353 cites W3179559990 @default.
• W4280503353 cites W3188030220 @default.
• W4280503353 cites W3196946116 @default.
• W4280503353 cites W3204110545 @default.
• W4280503353 cites W4211076612 @default.
• W4280503353 doi "https://doi.org/10.1016/j.apsb.2022.05.014" @default.
• W4280503353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36176916" @default.
• W4280503353 hasPublicationYear "2022" @default.
• W4280503353 type Work @default.
• W4280503353 citedByCount "3" @default.
• W4280503353 countsByYear W42805033532022 @default.
• W4280503353 countsByYear W42805033532023 @default.
• W4280503353 crossrefType "journal-article" @default.
• W4280503353 hasAuthorship W4280503353A5020420071 @default.
• W4280503353 hasAuthorship W4280503353A5038669556 @default.
• W4280503353 hasAuthorship W4280503353A5045954240 @default.
• W4280503353 hasAuthorship W4280503353A5048843008 @default.
• W4280503353 hasAuthorship W4280503353A5051557196 @default.
• W4280503353 hasAuthorship W4280503353A5066153198 @default.
• W4280503353 hasAuthorship W4280503353A5066557197 @default.
• W4280503353 hasAuthorship W4280503353A5071490696 @default.
• W4280503353 hasAuthorship W4280503353A5091531162 @default.
• W4280503353 hasBestOaLocation W42805033531 @default.
• W4280503353 hasConcept C130316041 @default.
• W4280503353 hasConcept C185592680 @default.
• W4280503353 hasConcept C203014093 @default.
• W4280503353 hasConcept C2776409635 @default.
• W4280503353 hasConcept C2776962512 @default.
• W4280503353 hasConcept C41625074 @default.
• W4280503353 hasConcept C501593827 @default.
• W4280503353 hasConcept C523546767 @default.
• W4280503353 hasConcept C54355233 @default.
• W4280503353 hasConcept C55493867 @default.
• W4280503353 hasConcept C58123911 @default.
• W4280503353 hasConcept C79879829 @default.
• W4280503353 hasConcept C86803240 @default.
• W4280503353 hasConcept C8891405 @default.
• W4280503353 hasConcept C89423630 @default.
• W4280503353 hasConceptScore W4280503353C130316041 @default.
• W4280503353 hasConceptScore W4280503353C185592680 @default.
• W4280503353 hasConceptScore W4280503353C203014093 @default.
• W4280503353 hasConceptScore W4280503353C2776409635 @default.
• W4280503353 hasConceptScore W4280503353C2776962512 @default.
• W4280503353 hasConceptScore W4280503353C41625074 @default.
• W4280503353 hasConceptScore W4280503353C501593827 @default.
• W4280503353 hasConceptScore W4280503353C523546767 @default.
• W4280503353 hasConceptScore W4280503353C54355233 @default.
• W4280503353 hasConceptScore W4280503353C55493867 @default.

• next