Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280505811> ?p ?o ?g. }
- W4280505811 abstract "Neuregulins (NRGs) are EGF-like ligands associated with cognitive disorders. Unprocessed proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but the subcellular site of proNRG3 cleavage, mechanisms underlying its transport into axons, and presynaptic accumulation remain unknown. Using an optogenetic proNRG3 cleavage reporter (LA143-NRG3), we investigate the spatial-temporal dynamics of NRG3 processing and sorting in neurons. In dark conditions, unprocessed LA143-NRG3 is retained in the trans-Golgi network but, upon photoactivation, is cleaved by BACE1 and released from the TGN. Mature NRG3 then emerges on the somatodendritic plasma membrane from where it is re-endocytosed and anterogradely transported on Rab4+ vesicles into axons via transcytosis. By contrast, the BACE1 substrate APP is sorted into axons on Rab11+ vesicles. Lastly, by a mechanism we denote trans-synaptic retention, NRG3 accumulates at presynaptic terminals by stable interaction with its receptor ErbB4 on postsynaptic GABAergic interneurons. We propose that trans-synaptic retention may account for polarized expression of other neuronal transmembrane ligands and receptors." @default.
- W4280505811 created "2022-05-22" @default.
- W4280505811 creator A5040810659 @default.
- W4280505811 creator A5046389564 @default.
- W4280505811 creator A5058152560 @default.
- W4280505811 creator A5063367873 @default.
- W4280505811 creator A5074929587 @default.
- W4280505811 creator A5081989475 @default.
- W4280505811 creator A5083726193 @default.
- W4280505811 creator A5091316775 @default.
- W4280505811 date "2022-05-17" @default.
- W4280505811 modified "2023-10-09" @default.
- W4280505811 title "Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3" @default.
- W4280505811 cites W1577015300 @default.
- W4280505811 cites W1664511950 @default.
- W4280505811 cites W1848481221 @default.
- W4280505811 cites W1960895270 @default.
- W4280505811 cites W1970662525 @default.
- W4280505811 cites W1977688919 @default.
- W4280505811 cites W1978260512 @default.
- W4280505811 cites W1980882343 @default.
- W4280505811 cites W1980988460 @default.
- W4280505811 cites W1991738499 @default.
- W4280505811 cites W1999242469 @default.
- W4280505811 cites W2003283600 @default.
- W4280505811 cites W2006778524 @default.
- W4280505811 cites W2009470502 @default.
- W4280505811 cites W2016394661 @default.
- W4280505811 cites W2017418297 @default.
- W4280505811 cites W2021095126 @default.
- W4280505811 cites W2023527463 @default.
- W4280505811 cites W2036484541 @default.
- W4280505811 cites W2039919932 @default.
- W4280505811 cites W2042190017 @default.
- W4280505811 cites W2043345702 @default.
- W4280505811 cites W2047007360 @default.
- W4280505811 cites W2049383416 @default.
- W4280505811 cites W2053413911 @default.
- W4280505811 cites W2066015352 @default.
- W4280505811 cites W2066994840 @default.
- W4280505811 cites W2068107769 @default.
- W4280505811 cites W2070715397 @default.
- W4280505811 cites W2073570989 @default.
- W4280505811 cites W2083831897 @default.
- W4280505811 cites W2092143480 @default.
- W4280505811 cites W2099634214 @default.
- W4280505811 cites W2102535585 @default.
- W4280505811 cites W2105342083 @default.
- W4280505811 cites W2105616339 @default.
- W4280505811 cites W2110293902 @default.
- W4280505811 cites W2111147277 @default.
- W4280505811 cites W2112369131 @default.
- W4280505811 cites W2112546324 @default.
- W4280505811 cites W2122990248 @default.
- W4280505811 cites W2124813164 @default.
- W4280505811 cites W2132582952 @default.
- W4280505811 cites W2137575965 @default.
- W4280505811 cites W2139018071 @default.
- W4280505811 cites W2140259754 @default.
- W4280505811 cites W2140486223 @default.
- W4280505811 cites W2141253960 @default.
- W4280505811 cites W2145625192 @default.
- W4280505811 cites W2154156417 @default.
- W4280505811 cites W2157860584 @default.
- W4280505811 cites W2157981718 @default.
- W4280505811 cites W2158920923 @default.
- W4280505811 cites W2164187120 @default.
- W4280505811 cites W2200418872 @default.
- W4280505811 cites W2221662528 @default.
- W4280505811 cites W2314930926 @default.
- W4280505811 cites W2327760377 @default.
- W4280505811 cites W2346421879 @default.
- W4280505811 cites W2408312243 @default.
- W4280505811 cites W2471187111 @default.
- W4280505811 cites W2471279405 @default.
- W4280505811 cites W2511994987 @default.
- W4280505811 cites W2512398432 @default.
- W4280505811 cites W2520836933 @default.
- W4280505811 cites W2536528507 @default.
- W4280505811 cites W2582355594 @default.
- W4280505811 cites W2584710572 @default.
- W4280505811 cites W2584733781 @default.
- W4280505811 cites W2593525482 @default.
- W4280505811 cites W2600386456 @default.
- W4280505811 cites W2606341184 @default.
- W4280505811 cites W2617060458 @default.
- W4280505811 cites W2756126750 @default.
- W4280505811 cites W2763128392 @default.
- W4280505811 cites W2763150057 @default.
- W4280505811 cites W2792166692 @default.
- W4280505811 cites W2792890945 @default.
- W4280505811 cites W2794343599 @default.
- W4280505811 cites W2796023029 @default.
- W4280505811 cites W2796287846 @default.
- W4280505811 cites W2796633312 @default.
- W4280505811 cites W2802487502 @default.
- W4280505811 cites W2883892282 @default.
- W4280505811 cites W2897607400 @default.
- W4280505811 cites W2915426823 @default.
- W4280505811 cites W2942810947 @default.