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- W4280505905 endingPage "105749" @default.
- W4280505905 startingPage "105749" @default.
- W4280505905 abstract "Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes. Stress granules are dynamic cytosolic storage hubs for mRNAs in response to stress exposures, that are evolutionarily conserved cytoplasmic RNA granules in somatic cells. A lot of previous studies have shown that the impaired stress granules are crucial events in SMA/ALS pathogenesis. In this review, we described the key stress granules related RNA binding proteins (SMN, TDP-43, and FUS) involved in SMA/ALS, summarized the reported mutations in these RNA binding proteins involved in SMA/ALS pathogenesis, and discussed the mechanisms through which stress granules dynamics participate in the diseases. Meanwhile, we described the applications and limitation of current therapies targeting SMA/ALS. We futher proposed the promising targets on stress granules in the future therapeutic interventions of SMA/ALS." @default.
- W4280505905 created "2022-05-22" @default.
- W4280505905 creator A5002649440 @default.
- W4280505905 creator A5014195038 @default.
- W4280505905 creator A5017059424 @default.
- W4280505905 creator A5052645685 @default.
- W4280505905 creator A5063985740 @default.
- W4280505905 creator A5085162947 @default.
- W4280505905 date "2022-08-01" @default.
- W4280505905 modified "2023-10-09" @default.
- W4280505905 title "Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy" @default.
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