Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280506452> ?p ?o ?g. }
- W4280506452 endingPage "38" @default.
- W4280506452 startingPage "25" @default.
- W4280506452 abstract "Abstract Low-density lipoprotein (LDL) is the main carrier of cholesterol and cholesteryl ester in circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of atherosclerotic cardiovascular disease (ASCVD). LDL-C lowering is recommended by many guidelines for the prevention and treatment of ASCVD. Statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors are the mainstay of LDL-C-lowering therapy. Novel therapies are also emerging for patients who are intolerant to statins or respond poorly to standard treatments. Here, we review the most recent advances on LDL-C-lowering drugs, focusing on the mechanisms by which they act to reduce LDL-C levels. The article starts with the cornerstone therapies applicable to most patients at risk for ASCVD. Special treatments for those with little or no LDL receptor function then follow. The inhibitors of ATP-citrate lyase and cholesteryl ester transfer protein, which are recently approved and still under investigation for LDL-C lowering, respectively, are also included. Strategies targeting the stability of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol catabolism can be novel regimens to reduce LDL-C levels and cardiovascular risk." @default.
- W4280506452 created "2022-05-22" @default.
- W4280506452 creator A5001317899 @default.
- W4280506452 creator A5034582366 @default.
- W4280506452 creator A5069645681 @default.
- W4280506452 date "2022-05-20" @default.
- W4280506452 modified "2023-10-16" @default.
- W4280506452 title "Lowering low-density lipoprotein cholesterol: from mechanisms to therapies" @default.
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