Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280507319> ?p ?o ?g. }
- W4280507319 endingPage "12547" @default.
- W4280507319 startingPage "12532" @default.
- W4280507319 abstract "Recent studies have shown that the expression of integrin-linked kinase (ILK) was related to the occurrence, development, and malignant progression of esophageal squamous cell carcinoma (ESCC). However, research on the relationship between ILK and the chemosensitivity of ESCC has to date not been reported. The present study found that ILK was highly expressed in ESCC cell lines, and the overexpression of ILK in ESCC cells reduced the incidence of cell apoptosis and alleviated the cytotoxicity on cells induced by cisplatin (CDDP). Inversely, ILK knockdown increased CDDP-induced apoptosis and had an inhibitive effect on the malignant phenotype of ESCC, including cell proliferation, invasion, and migration. In addition, ILK knockdown in ESCC cells inhibited the expression of beta (β)-catenin and activated the wingless/integrated (Wnt) signaling pathway. Furthermore, cellular MYC (c-MYC) and Cylin D1 were the target genes of the Wnt signaling pathway. Rescue experiments showed that the overexpression of β-catenin reversed a tumor's inhibition and apoptosis abilities induced by ILK knockdown. In conclusion, ILK potentially reduced the CDDP sensitivity of ESCC cells by influencing the activity of the Wnt/β-catenin signaling pathway." @default.
- W4280507319 created "2022-05-22" @default.
- W4280507319 creator A5027305986 @default.
- W4280507319 creator A5029496793 @default.
- W4280507319 creator A5050271178 @default.
- W4280507319 creator A5062662220 @default.
- W4280507319 creator A5066716873 @default.
- W4280507319 creator A5080125836 @default.
- W4280507319 creator A5081207491 @default.
- W4280507319 date "2022-05-02" @default.
- W4280507319 modified "2023-10-18" @default.
- W4280507319 title "Integrin-linked kinase affects the sensitivity of esophageal squamous cell carcinoma cells to chemotherapy with cisplatin via the Wnt/beta-catenin signaling pathway" @default.
- W4280507319 cites W1634699770 @default.
- W4280507319 cites W1965016416 @default.
- W4280507319 cites W1978323717 @default.
- W4280507319 cites W1987604182 @default.
- W4280507319 cites W2008182675 @default.
- W4280507319 cites W2034153554 @default.
- W4280507319 cites W2044136921 @default.
- W4280507319 cites W2045027538 @default.
- W4280507319 cites W2098409094 @default.
- W4280507319 cites W2109022558 @default.
- W4280507319 cites W2117692326 @default.
- W4280507319 cites W2143826746 @default.
- W4280507319 cites W2146264066 @default.
- W4280507319 cites W2215998033 @default.
- W4280507319 cites W2414382975 @default.
- W4280507319 cites W2491021144 @default.
- W4280507319 cites W2494728190 @default.
- W4280507319 cites W2509097171 @default.
- W4280507319 cites W2518651700 @default.
- W4280507319 cites W2746180355 @default.
- W4280507319 cites W2769755414 @default.
- W4280507319 cites W2774025967 @default.
- W4280507319 cites W2885571568 @default.
- W4280507319 cites W2891699854 @default.
- W4280507319 cites W2969997266 @default.
- W4280507319 cites W2978483190 @default.
- W4280507319 cites W2979492661 @default.
- W4280507319 cites W3014637457 @default.
- W4280507319 cites W3021909056 @default.
- W4280507319 cites W3037019180 @default.
- W4280507319 cites W3092399836 @default.
- W4280507319 cites W3128646645 @default.
- W4280507319 cites W3134145478 @default.
- W4280507319 cites W3210808671 @default.
- W4280507319 cites W4200004953 @default.
- W4280507319 cites W4210252269 @default.
- W4280507319 cites W4210613551 @default.
- W4280507319 cites W4211048478 @default.
- W4280507319 cites W4225863250 @default.
- W4280507319 doi "https://doi.org/10.1080/21655979.2022.2076497" @default.
- W4280507319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35587162" @default.
- W4280507319 hasPublicationYear "2022" @default.
- W4280507319 type Work @default.
- W4280507319 citedByCount "1" @default.
- W4280507319 countsByYear W42805073192022 @default.
- W4280507319 crossrefType "journal-article" @default.
- W4280507319 hasAuthorship W4280507319A5027305986 @default.
- W4280507319 hasAuthorship W4280507319A5029496793 @default.
- W4280507319 hasAuthorship W4280507319A5050271178 @default.
- W4280507319 hasAuthorship W4280507319A5062662220 @default.
- W4280507319 hasAuthorship W4280507319A5066716873 @default.
- W4280507319 hasAuthorship W4280507319A5080125836 @default.
- W4280507319 hasAuthorship W4280507319A5081207491 @default.
- W4280507319 hasBestOaLocation W42805073191 @default.
- W4280507319 hasConcept C137620995 @default.
- W4280507319 hasConcept C1491633281 @default.
- W4280507319 hasConcept C173396325 @default.
- W4280507319 hasConcept C185592680 @default.
- W4280507319 hasConcept C190283241 @default.
- W4280507319 hasConcept C2776694085 @default.
- W4280507319 hasConcept C2778239845 @default.
- W4280507319 hasConcept C29537977 @default.
- W4280507319 hasConcept C30145163 @default.
- W4280507319 hasConcept C502942594 @default.
- W4280507319 hasConcept C54355233 @default.
- W4280507319 hasConcept C55493867 @default.
- W4280507319 hasConcept C62112901 @default.
- W4280507319 hasConcept C62478195 @default.
- W4280507319 hasConcept C66417403 @default.
- W4280507319 hasConcept C82495950 @default.
- W4280507319 hasConcept C86803240 @default.
- W4280507319 hasConcept C95444343 @default.
- W4280507319 hasConceptScore W4280507319C137620995 @default.
- W4280507319 hasConceptScore W4280507319C1491633281 @default.
- W4280507319 hasConceptScore W4280507319C173396325 @default.
- W4280507319 hasConceptScore W4280507319C185592680 @default.
- W4280507319 hasConceptScore W4280507319C190283241 @default.
- W4280507319 hasConceptScore W4280507319C2776694085 @default.
- W4280507319 hasConceptScore W4280507319C2778239845 @default.
- W4280507319 hasConceptScore W4280507319C29537977 @default.
- W4280507319 hasConceptScore W4280507319C30145163 @default.
- W4280507319 hasConceptScore W4280507319C502942594 @default.
- W4280507319 hasConceptScore W4280507319C54355233 @default.
- W4280507319 hasConceptScore W4280507319C55493867 @default.
- W4280507319 hasConceptScore W4280507319C62112901 @default.
- W4280507319 hasConceptScore W4280507319C62478195 @default.