Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280509393> ?p ?o ?g. }
- W4280509393 abstract "Cholangiocarcinoma (CCA) is an aggressive malignancy originating from the epithelium of the bile duct. The prognosis of patients is poor regardless of radical resection and chemoradiotherapy. The current classification and prognostic model of CCA are unable to satisfy the requirements for predicting the clinical outcome and exploring therapeutic targets. Estrogen signaling is involved in diverse cancer types, and it has long been established that CCA could be regulated by estrogen. In our study, estrogen response was identified to be significantly and stably correlated with poor prognosis in CCA. Employing several algorithms, CCA was classified into ES cluster A and B. ES cluster B was mainly composed of patients with fluke infection and overlapped with CCA cluster 1/2, and ES cluster A was mainly composed of patients without fluke infection and overlapped with CCA cluster 3/4. COMT and HSD17B1 were identified to be responsible for the differential estrogen response between ES clusters A and B, and the estrogen response may be correlated with the differentiation and cancer stemness of CCA at the single-cell level. Complement activation and the expression of C3 and C5, which are mainly expressed by CCA cells, were significantly downregulated in ES cluster B. An estrogen response risk score (ESRS) model was constructed to predict the prognosis of CCA, followed by a nomogram integrating ESRS and clinical features. Finally, altered pathways, applicable drugs and sensitivity to chemical drugs were analyzed specific to the estrogen response. In summary, our results provide insights into the role of the estrogen response in CCA progression as well as applicable drugs and potential therapeutic targets in estrogen metabolism, the complement system and ESRS-related pathways." @default.
- W4280509393 created "2022-05-22" @default.
- W4280509393 creator A5000723230 @default.
- W4280509393 creator A5001498982 @default.
- W4280509393 creator A5010479652 @default.
- W4280509393 creator A5026329292 @default.
- W4280509393 creator A5028990016 @default.
- W4280509393 creator A5033756760 @default.
- W4280509393 creator A5051086315 @default.
- W4280509393 creator A5059712164 @default.
- W4280509393 creator A5059939560 @default.
- W4280509393 creator A5076567125 @default.
- W4280509393 creator A5087927442 @default.
- W4280509393 creator A5087984298 @default.
- W4280509393 date "2022-05-19" @default.
- W4280509393 modified "2023-09-26" @default.
- W4280509393 title "Characterization of the Estrogen Response Helps to Predict Prognosis and Identify Potential Therapeutic Targets in Cholangiocarcinoma" @default.
- W4280509393 cites W1434070074 @default.
- W4280509393 cites W1551396388 @default.
- W4280509393 cites W1786886910 @default.
- W4280509393 cites W1849763436 @default.
- W4280509393 cites W1932669647 @default.
- W4280509393 cites W1969000560 @default.
- W4280509393 cites W1985960971 @default.
- W4280509393 cites W1989573061 @default.
- W4280509393 cites W2001008402 @default.
- W4280509393 cites W2007363086 @default.
- W4280509393 cites W2008500457 @default.
- W4280509393 cites W2009787864 @default.
- W4280509393 cites W2018469741 @default.
- W4280509393 cites W2024852746 @default.
- W4280509393 cites W2042619042 @default.
- W4280509393 cites W2044266070 @default.
- W4280509393 cites W2054009039 @default.
- W4280509393 cites W2054039401 @default.
- W4280509393 cites W2062999758 @default.
- W4280509393 cites W2076936113 @default.
- W4280509393 cites W2079702499 @default.
- W4280509393 cites W2100773081 @default.
- W4280509393 cites W2101474893 @default.
- W4280509393 cites W2107410297 @default.
- W4280509393 cites W2112079089 @default.
- W4280509393 cites W2115261608 @default.
- W4280509393 cites W2120865735 @default.
- W4280509393 cites W2121604817 @default.
- W4280509393 cites W2133503086 @default.
- W4280509393 cites W2159203244 @default.
- W4280509393 cites W2169935273 @default.
- W4280509393 cites W2222784674 @default.
- W4280509393 cites W2554144052 @default.
- W4280509393 cites W2612467560 @default.
- W4280509393 cites W2640734494 @default.
- W4280509393 cites W2724543993 @default.
- W4280509393 cites W2760423124 @default.
- W4280509393 cites W2763492611 @default.
- W4280509393 cites W2764536335 @default.
- W4280509393 cites W2775288206 @default.
- W4280509393 cites W2777085303 @default.
- W4280509393 cites W2795395475 @default.
- W4280509393 cites W2800502538 @default.
- W4280509393 cites W2808640273 @default.
- W4280509393 cites W2883708472 @default.
- W4280509393 cites W2897133708 @default.
- W4280509393 cites W2901939741 @default.
- W4280509393 cites W2920333686 @default.
- W4280509393 cites W2920849174 @default.
- W4280509393 cites W2938697269 @default.
- W4280509393 cites W2944748061 @default.
- W4280509393 cites W2949177718 @default.
- W4280509393 cites W2964012416 @default.
- W4280509393 cites W2965447408 @default.
- W4280509393 cites W2982426375 @default.
- W4280509393 cites W2988773550 @default.
- W4280509393 cites W2995880398 @default.
- W4280509393 cites W3005935248 @default.
- W4280509393 cites W3006039958 @default.
- W4280509393 cites W3015521901 @default.
- W4280509393 cites W3033473768 @default.
- W4280509393 cites W3039360174 @default.
- W4280509393 cites W3045618018 @default.
- W4280509393 cites W3091618832 @default.
- W4280509393 cites W3108136355 @default.
- W4280509393 cites W3110220269 @default.
- W4280509393 cites W3133939649 @default.
- W4280509393 cites W3162054315 @default.
- W4280509393 cites W3178601061 @default.
- W4280509393 cites W4211248913 @default.
- W4280509393 cites W4255278570 @default.
- W4280509393 doi "https://doi.org/10.3389/fonc.2022.870840" @default.
- W4280509393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35664769" @default.
- W4280509393 hasPublicationYear "2022" @default.
- W4280509393 type Work @default.
- W4280509393 citedByCount "0" @default.
- W4280509393 crossrefType "journal-article" @default.
- W4280509393 hasAuthorship W4280509393A5000723230 @default.
- W4280509393 hasAuthorship W4280509393A5001498982 @default.
- W4280509393 hasAuthorship W4280509393A5010479652 @default.
- W4280509393 hasAuthorship W4280509393A5026329292 @default.
- W4280509393 hasAuthorship W4280509393A5028990016 @default.
- W4280509393 hasAuthorship W4280509393A5033756760 @default.