FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280510775> ?p ?o ?g. }

• W4280510775 endingPage "961" @default.
• W4280510775 startingPage "952" @default.
• W4280510775 abstract "Pancreatic ductal adenocarcinoma (PDAC) mainly occurs in older adults. Since randomized clinical trials (RCTs) provide the highest-quality evidence incorporated in NCCN recommendations, the underrepresentation of older patients in RCTs challenges guidelines' external validity and limits the solidity of evidence in this specific population.The study aimed to investigate external validity of NCCN guidelines for PDCA and the impact of reference studies eligibility on overall survival (OS) in a real-world older population. We retrieved RCTs supporting NCCN recommendations for management of PDAC and identified ten topics. We matched a cohort of 707 PDAC patients aged ≥70 years from the Moffitt Cancer Center database with eligibility criteria of 96 reference RCTs to check the proportion of patients eligible for at least two RCTs. Eligibility >60% was rated full validity, 30%-60% partial validity and < 30% limited validity. We also performed log-rank test to assessed whether eligibility status affects OS, stratifying by age (70-74; 75-79; ≥80).We found full validity for neoadjuvant (57/73 patients; 69.86%), locally advanced (28/39; 71.79%) and second line (88/110; 80%) treatment, while lowest validity was found for adjuvant chemotherapy (37/86; 43%). Eligible status was correlated with a significant OS benefit for adjuvant chemoradiation (p = 0.002) in all-comers and for first-line polychemotherapy in patients aged ≥80 (p = 0.01). Our analysis supports the limitation of guidelines' external validity in older patients, and hints at possible correlations with survival, although no definitive conclusions can be drawn at this stage. Renewing RCT design with broader eligibility criteria might help increase inclusion of older and thus strengthen the evidence." @default.
• W4280510775 created "2022-05-22" @default.
• W4280510775 creator A5006750441 @default.
• W4280510775 creator A5059011283 @default.
• W4280510775 creator A5063201200 @default.
• W4280510775 creator A5064716632 @default.
• W4280510775 creator A5065506630 @default.
• W4280510775 date "2022-09-01" @default.
• W4280510775 modified "2023-09-25" @default.
• W4280510775 title "Assessment of the external validity of the National Comprehensive Cancer Network (NCCN) guidelines for pancreatic ductal adenocarcinoma in a population of older patients aged 70 years and older" @default.
• W4280510775 cites W1942564037 @default.
• W4280510775 cites W1986425690 @default.
• W4280510775 cites W1987945639 @default.
• W4280510775 cites W1991020867 @default.
• W4280510775 cites W2015712245 @default.
• W4280510775 cites W2034401866 @default.
• W4280510775 cites W2045805729 @default.
• W4280510775 cites W2091267779 @default.
• W4280510775 cites W2101346953 @default.
• W4280510775 cites W2108425422 @default.
• W4280510775 cites W2120729896 @default.
• W4280510775 cites W2126856198 @default.
• W4280510775 cites W2142960568 @default.
• W4280510775 cites W2145975717 @default.
• W4280510775 cites W2153294383 @default.
• W4280510775 cites W2155097929 @default.
• W4280510775 cites W2159296014 @default.
• W4280510775 cites W2163709153 @default.
• W4280510775 cites W2475260156 @default.
• W4280510775 cites W2600086771 @default.
• W4280510775 cites W2809213740 @default.
• W4280510775 cites W2904603743 @default.
• W4280510775 cites W2948757873 @default.
• W4280510775 cites W3091199432 @default.
• W4280510775 cites W3209288009 @default.
• W4280510775 doi "https://doi.org/10.1016/j.jgo.2022.04.015" @default.
• W4280510775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35597730" @default.
• W4280510775 hasPublicationYear "2022" @default.
• W4280510775 type Work @default.
• W4280510775 citedByCount "1" @default.
• W4280510775 countsByYear W42805107752023 @default.
• W4280510775 crossrefType "journal-article" @default.
• W4280510775 hasAuthorship W4280510775A5006750441 @default.
• W4280510775 hasAuthorship W4280510775A5059011283 @default.
• W4280510775 hasAuthorship W4280510775A5063201200 @default.
• W4280510775 hasAuthorship W4280510775A5064716632 @default.
• W4280510775 hasAuthorship W4280510775A5065506630 @default.
• W4280510775 hasConcept C121608353 @default.
• W4280510775 hasConcept C126322002 @default.
• W4280510775 hasConcept C143998085 @default.
• W4280510775 hasConcept C15744967 @default.
• W4280510775 hasConcept C168563851 @default.
• W4280510775 hasConcept C174106493 @default.
• W4280510775 hasConcept C2780210213 @default.
• W4280510775 hasConcept C2908647359 @default.
• W4280510775 hasConcept C2992026798 @default.
• W4280510775 hasConcept C71924100 @default.
• W4280510775 hasConcept C72563966 @default.
• W4280510775 hasConcept C77805123 @default.
• W4280510775 hasConcept C99454951 @default.
• W4280510775 hasConceptScore W4280510775C121608353 @default.
• W4280510775 hasConceptScore W4280510775C126322002 @default.
• W4280510775 hasConceptScore W4280510775C143998085 @default.
• W4280510775 hasConceptScore W4280510775C15744967 @default.
• W4280510775 hasConceptScore W4280510775C168563851 @default.
• W4280510775 hasConceptScore W4280510775C174106493 @default.
• W4280510775 hasConceptScore W4280510775C2780210213 @default.
• W4280510775 hasConceptScore W4280510775C2908647359 @default.
• W4280510775 hasConceptScore W4280510775C2992026798 @default.
• W4280510775 hasConceptScore W4280510775C71924100 @default.
• W4280510775 hasConceptScore W4280510775C72563966 @default.
• W4280510775 hasConceptScore W4280510775C77805123 @default.
• W4280510775 hasConceptScore W4280510775C99454951 @default.
• W4280510775 hasIssue "7" @default.
• W4280510775 hasLocation W42805107751 @default.
• W4280510775 hasLocation W42805107752 @default.
• W4280510775 hasOpenAccess W4280510775 @default.
• W4280510775 hasPrimaryLocation W42805107751 @default.
• W4280510775 hasRelatedWork W2114938072 @default.
• W4280510775 hasRelatedWork W2403481407 @default.
• W4280510775 hasRelatedWork W2595377073 @default.
• W4280510775 hasRelatedWork W2896367237 @default.
• W4280510775 hasRelatedWork W3104966608 @default.
• W4280510775 hasRelatedWork W3201615753 @default.
• W4280510775 hasRelatedWork W3204822232 @default.
• W4280510775 hasRelatedWork W4292448967 @default.
• W4280510775 hasRelatedWork W4317891151 @default.
• W4280510775 hasRelatedWork W4323857524 @default.
• W4280510775 hasVolume "13" @default.
• W4280510775 isParatext "false" @default.
• W4280510775 isRetracted "false" @default.
• W4280510775 workType "article" @default.