FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280511056> ?p ?o ?g. }

• W4280511056 abstract "Abstract During the first postnatal week in rodents, cholinergic retinal waves initiate in starburst amacrine cells (SACs), propagating to retinal ganglion cells (RGCs) and visual centers, essential for visual circuit refinement. By modulating exocytosis in SACs, dynamic changes in the protein kinase A (PKA) activity can regulate the spatiotemporal patterns of cholinergic waves. Previously, cysteine string protein-α (CSPα) is found to interact with the core exocytotic machinery by PKA-mediated phosphorylation at serine 10 (S10). However, whether PKA-mediated CSPα phosphorylation may regulate cholinergic waves via SACs remains unknown. Here, we examined how CSPα phosphorylation in SACs regulates cholinergic waves. First, we identified that CSPα1 is the major isoform in developing rat SACs and the inner plexiform layer during the first postnatal week. Using SAC-specific expression, we found that the CSPα1-PKA-phosphodeficient mutant (CSP-S10A) decreased wave frequency, but did not alter the wave spatial correlation compared to control, wild-type CSPα1 (CSP-WT), or two PKA-phosphomimetic mutants (CSP-S10D and CSP-S10E). These suggest that CSPα-S10 phosphodeficiency in SACs dampens the frequency of cholinergic waves. Moreover, the level of phospho-PKA substrates was significantly reduced in SACs overexpressing CSP-S10A compared to control or CSP-WT, suggesting that the dampened wave frequency is correlated with the decreased PKA activity. Further, compared to control or CSP-WT, CSP-S10A in SACs reduced the periodicity of wave-associated postsynaptic currents (PSCs) in neighboring RGCs, suggesting that these RGCs received the weakened synaptic inputs from SACs overexpressing CSP-S10A. Finally, CSP-S10A in SACs decreased the PSC amplitude and the slope to peak PSC compared to control or CSP-WT, suggesting that CSPα-S10 phosphodeficiency may dampen the speed of the SAC-RGC transmission. Thus, via PKA-mediated phosphorylation, CSPα in SACs may facilitate the SAC-RGC transmission, contributing to the robust frequency of cholinergic waves." @default.
• W4280511056 created "2022-05-22" @default.
• W4280511056 creator A5004521505 @default.
• W4280511056 creator A5033229583 @default.
• W4280511056 creator A5033412145 @default.
• W4280511056 creator A5072148616 @default.
• W4280511056 creator A5081835877 @default.
• W4280511056 creator A5089908897 @default.
• W4280511056 date "2022-01-01" @default.
• W4280511056 modified "2023-09-25" @default.
• W4280511056 title "Phosphorylation of cysteine string protein-α up-regulates the frequency of cholinergic waves <i>via</i> starburst amacrine cells" @default.
• W4280511056 cites W1551079907 @default.
• W4280511056 cites W1876590017 @default.
• W4280511056 cites W1972133451 @default.
• W4280511056 cites W1973759950 @default.
• W4280511056 cites W1986408320 @default.
• W4280511056 cites W2016891453 @default.
• W4280511056 cites W2020929196 @default.
• W4280511056 cites W2050215536 @default.
• W4280511056 cites W2054971033 @default.
• W4280511056 cites W2060601033 @default.
• W4280511056 cites W2068244727 @default.
• W4280511056 cites W2075977341 @default.
• W4280511056 cites W2076913269 @default.
• W4280511056 cites W2077306569 @default.
• W4280511056 cites W2083579647 @default.
• W4280511056 cites W2085654040 @default.
• W4280511056 cites W2094822213 @default.
• W4280511056 cites W2108528688 @default.
• W4280511056 cites W2109051910 @default.
• W4280511056 cites W2112572641 @default.
• W4280511056 cites W2113104319 @default.
• W4280511056 cites W2145935221 @default.
• W4280511056 cites W2150947418 @default.
• W4280511056 cites W2168821750 @default.
• W4280511056 cites W2172212230 @default.
• W4280511056 cites W2615550277 @default.
• W4280511056 cites W2913933444 @default.
• W4280511056 cites W3014564669 @default.
• W4280511056 doi "https://doi.org/10.1017/s0952523822000013" @default.
• W4280511056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35543445" @default.
• W4280511056 hasPublicationYear "2022" @default.
• W4280511056 type Work @default.
• W4280511056 citedByCount "0" @default.
• W4280511056 crossrefType "journal-article" @default.
• W4280511056 hasAuthorship W4280511056A5004521505 @default.
• W4280511056 hasAuthorship W4280511056A5033229583 @default.
• W4280511056 hasAuthorship W4280511056A5033412145 @default.
• W4280511056 hasAuthorship W4280511056A5072148616 @default.
• W4280511056 hasAuthorship W4280511056A5081835877 @default.
• W4280511056 hasAuthorship W4280511056A5089908897 @default.
• W4280511056 hasBestOaLocation W42805110561 @default.
• W4280511056 hasConcept C11960822 @default.
• W4280511056 hasConcept C169760540 @default.
• W4280511056 hasConcept C185592680 @default.
• W4280511056 hasConcept C22885893 @default.
• W4280511056 hasConcept C2777093970 @default.
• W4280511056 hasConcept C2778658801 @default.
• W4280511056 hasConcept C2780827179 @default.
• W4280511056 hasConcept C2781099447 @default.
• W4280511056 hasConcept C55493867 @default.
• W4280511056 hasConcept C86803240 @default.
• W4280511056 hasConcept C95444343 @default.
• W4280511056 hasConcept C97029542 @default.
• W4280511056 hasConceptScore W4280511056C11960822 @default.
• W4280511056 hasConceptScore W4280511056C169760540 @default.
• W4280511056 hasConceptScore W4280511056C185592680 @default.
• W4280511056 hasConceptScore W4280511056C22885893 @default.
• W4280511056 hasConceptScore W4280511056C2777093970 @default.
• W4280511056 hasConceptScore W4280511056C2778658801 @default.
• W4280511056 hasConceptScore W4280511056C2780827179 @default.
• W4280511056 hasConceptScore W4280511056C2781099447 @default.
• W4280511056 hasConceptScore W4280511056C55493867 @default.
• W4280511056 hasConceptScore W4280511056C86803240 @default.
• W4280511056 hasConceptScore W4280511056C95444343 @default.
• W4280511056 hasConceptScore W4280511056C97029542 @default.
• W4280511056 hasFunder F4320309618 @default.
• W4280511056 hasFunder F4320323900 @default.
• W4280511056 hasLocation W42805110561 @default.
• W4280511056 hasLocation W42805110562 @default.
• W4280511056 hasLocation W42805110563 @default.
• W4280511056 hasOpenAccess W4280511056 @default.
• W4280511056 hasPrimaryLocation W42805110561 @default.
• W4280511056 hasRelatedWork W1967848881 @default.
• W4280511056 hasRelatedWork W1979118159 @default.
• W4280511056 hasRelatedWork W1986302039 @default.
• W4280511056 hasRelatedWork W2042468032 @default.
• W4280511056 hasRelatedWork W2076192127 @default.
• W4280511056 hasRelatedWork W2091497180 @default.
• W4280511056 hasRelatedWork W2120457078 @default.
• W4280511056 hasRelatedWork W2145279055 @default.
• W4280511056 hasRelatedWork W2157233023 @default.
• W4280511056 hasRelatedWork W4233275447 @default.
• W4280511056 hasVolume "39" @default.
• W4280511056 isParatext "false" @default.
• W4280511056 isRetracted "false" @default.
• W4280511056 workType "article" @default.