Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280512715> ?p ?o ?g. }
- W4280512715 endingPage "105878" @default.
- W4280512715 startingPage "105878" @default.
- W4280512715 abstract "A series of purine ribonucleosides bearing chiral amino acid amides at the C6 position of 2-chloropurine was synthesized. Molecular docking of the synthesized analogs of 2-chloroadenosine by their affinity for A1 adenosine receptors (A1ARs) was conducted. The investigation of A1AR stimulating activity of synthesized nucleosides was carried out in a model of an isolated mouse atrium. We have shown that derivatives with tyrosine, valine, and serine residues exhibit the properties of A1AR partial agonists. Animal experiments in the open field test have shown that these compounds have different profiles of psychoactive action. These nucleosides have an ophthalmic hypotensive effect and reduce intraocular pressure in a manner slightly inferior to that of timolol and brimonidine. The synthesized nucleosides can be the basis for further design and synthesis of new A1AR agonists." @default.
- W4280512715 created "2022-05-22" @default.
- W4280512715 creator A5008792789 @default.
- W4280512715 creator A5011093241 @default.
- W4280512715 creator A5011734229 @default.
- W4280512715 creator A5020289297 @default.
- W4280512715 creator A5023484851 @default.
- W4280512715 creator A5025665721 @default.
- W4280512715 creator A5029595212 @default.
- W4280512715 creator A5030959893 @default.
- W4280512715 creator A5039017409 @default.
- W4280512715 creator A5040839163 @default.
- W4280512715 creator A5040926273 @default.
- W4280512715 creator A5043318142 @default.
- W4280512715 creator A5052930403 @default.
- W4280512715 creator A5054283916 @default.
- W4280512715 creator A5069993347 @default.
- W4280512715 creator A5070093604 @default.
- W4280512715 creator A5080133403 @default.
- W4280512715 creator A5081710389 @default.
- W4280512715 date "2022-09-01" @default.
- W4280512715 modified "2023-10-16" @default.
- W4280512715 title "Synthesis of 2-chloropurine ribosides with chiral amino acid amides at C6 and their evaluation as A1 adenosine receptor agonists" @default.
- W4280512715 cites W1523007007 @default.
- W4280512715 cites W1971024460 @default.
- W4280512715 cites W1973568125 @default.
- W4280512715 cites W1973720318 @default.
- W4280512715 cites W1976173045 @default.
- W4280512715 cites W1977870991 @default.
- W4280512715 cites W1978311811 @default.
- W4280512715 cites W1985598247 @default.
- W4280512715 cites W1992070649 @default.
- W4280512715 cites W1995619131 @default.
- W4280512715 cites W2003366915 @default.
- W4280512715 cites W2008624230 @default.
- W4280512715 cites W2015157273 @default.
- W4280512715 cites W2015184023 @default.
- W4280512715 cites W2019839407 @default.
- W4280512715 cites W2023535350 @default.
- W4280512715 cites W2031751615 @default.
- W4280512715 cites W2031862972 @default.
- W4280512715 cites W2036927874 @default.
- W4280512715 cites W2037283014 @default.
- W4280512715 cites W2040578932 @default.
- W4280512715 cites W2042263119 @default.
- W4280512715 cites W2050893326 @default.
- W4280512715 cites W2052805172 @default.
- W4280512715 cites W2053570360 @default.
- W4280512715 cites W2053968879 @default.
- W4280512715 cites W2056964260 @default.
- W4280512715 cites W2066774123 @default.
- W4280512715 cites W2087605474 @default.
- W4280512715 cites W2093777829 @default.
- W4280512715 cites W2094515040 @default.
- W4280512715 cites W2101078720 @default.
- W4280512715 cites W2104916446 @default.
- W4280512715 cites W2121975625 @default.
- W4280512715 cites W2131690255 @default.
- W4280512715 cites W2132088139 @default.
- W4280512715 cites W2132629607 @default.
- W4280512715 cites W2139954389 @default.
- W4280512715 cites W2143644773 @default.
- W4280512715 cites W2162011385 @default.
- W4280512715 cites W2163117203 @default.
- W4280512715 cites W2319604146 @default.
- W4280512715 cites W2320559812 @default.
- W4280512715 cites W2322903026 @default.
- W4280512715 cites W2389005817 @default.
- W4280512715 cites W2497817158 @default.
- W4280512715 cites W2781763261 @default.
- W4280512715 cites W2788126937 @default.
- W4280512715 cites W2802492120 @default.
- W4280512715 cites W2809171792 @default.
- W4280512715 cites W2914321595 @default.
- W4280512715 cites W2946412700 @default.
- W4280512715 cites W2950774654 @default.
- W4280512715 cites W2951192254 @default.
- W4280512715 cites W2951353662 @default.
- W4280512715 cites W2953358969 @default.
- W4280512715 cites W2963674703 @default.
- W4280512715 cites W2974378695 @default.
- W4280512715 cites W3111070067 @default.
- W4280512715 cites W3123241806 @default.
- W4280512715 cites W3134592884 @default.
- W4280512715 cites W3141993092 @default.
- W4280512715 cites W3168315206 @default.
- W4280512715 doi "https://doi.org/10.1016/j.bioorg.2022.105878" @default.
- W4280512715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35660725" @default.
- W4280512715 hasPublicationYear "2022" @default.
- W4280512715 type Work @default.
- W4280512715 citedByCount "2" @default.
- W4280512715 countsByYear W42805127152023 @default.
- W4280512715 crossrefType "journal-article" @default.
- W4280512715 hasAuthorship W4280512715A5008792789 @default.
- W4280512715 hasAuthorship W4280512715A5011093241 @default.
- W4280512715 hasAuthorship W4280512715A5011734229 @default.
- W4280512715 hasAuthorship W4280512715A5020289297 @default.
- W4280512715 hasAuthorship W4280512715A5023484851 @default.