Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280516779> ?p ?o ?g. }
- W4280516779 abstract "Non-obstructive azoospermia (NOA) is one of the most important causes of male infertility. Although many congenital factors have been identified, the aetiology in the majority of idiopathic NOA (iNOA) cases remains unknown. Herein, using single-cell RNA-Seq data sets (GSE149512) from the Gene Expression Omnibus (GEO) database, we constructed transcriptional regulatory networks (TRNs) to explain the mutual regulatory relationship and the causal relationship between transcription factors (TFs). We defined 10 testicular cell types by their marker genes and found that the proportion of Leydig cells (LCs) and macrophages (tMΦ) was significantly increased in iNOA testis. We identified specific TFs including LHX9, KLF8, KLF4, ARID5B and RXRG in iNOA LCs. In addition, we found specific TFs in iNOA tMΦ such as POU2F2, SPIB IRF5, CEBPA, ELK4 and KLF6. All these identified TFs are strongly engaged in cellular fate, function and homeostasis of the microenvironment. Changes in the activity of the above-mentioned TFs might affect the function of LCs and tMΦ and ultimately cause spermatogenesis failure. This study illustrate that these TFs play important regulatory roles in the occurrence and development of NOA." @default.
- W4280516779 created "2022-05-22" @default.
- W4280516779 creator A5003665601 @default.
- W4280516779 creator A5017737983 @default.
- W4280516779 creator A5019871897 @default.
- W4280516779 creator A5020359488 @default.
- W4280516779 creator A5033199180 @default.
- W4280516779 creator A5038550017 @default.
- W4280516779 creator A5044561894 @default.
- W4280516779 creator A5046814170 @default.
- W4280516779 creator A5055265137 @default.
- W4280516779 creator A5070262411 @default.
- W4280516779 date "2022-05-20" @default.
- W4280516779 modified "2023-09-30" @default.
- W4280516779 title "Single-Cell Transcriptomics-Based Study of Transcriptional Regulatory Features in the Non-Obstructive Azoospermia Testis" @default.
- W4280516779 cites W1636205509 @default.
- W4280516779 cites W1723001059 @default.
- W4280516779 cites W1877167531 @default.
- W4280516779 cites W1893625392 @default.
- W4280516779 cites W1963745085 @default.
- W4280516779 cites W1999378743 @default.
- W4280516779 cites W2009806338 @default.
- W4280516779 cites W2048971937 @default.
- W4280516779 cites W2062656093 @default.
- W4280516779 cites W2089467986 @default.
- W4280516779 cites W2093029383 @default.
- W4280516779 cites W2093799212 @default.
- W4280516779 cites W2104974259 @default.
- W4280516779 cites W2113613985 @default.
- W4280516779 cites W2141337056 @default.
- W4280516779 cites W2146512944 @default.
- W4280516779 cites W2148035486 @default.
- W4280516779 cites W2159707944 @default.
- W4280516779 cites W2160333540 @default.
- W4280516779 cites W2167202160 @default.
- W4280516779 cites W2214074259 @default.
- W4280516779 cites W2301449312 @default.
- W4280516779 cites W2471970444 @default.
- W4280516779 cites W2511896561 @default.
- W4280516779 cites W2538234995 @default.
- W4280516779 cites W2616922646 @default.
- W4280516779 cites W2626725198 @default.
- W4280516779 cites W2744175726 @default.
- W4280516779 cites W2747545374 @default.
- W4280516779 cites W2783975438 @default.
- W4280516779 cites W2788348358 @default.
- W4280516779 cites W2792735064 @default.
- W4280516779 cites W2794480084 @default.
- W4280516779 cites W2796213339 @default.
- W4280516779 cites W2800291724 @default.
- W4280516779 cites W2803714017 @default.
- W4280516779 cites W2808260066 @default.
- W4280516779 cites W2892973347 @default.
- W4280516779 cites W2895456557 @default.
- W4280516779 cites W2900569297 @default.
- W4280516779 cites W2901163605 @default.
- W4280516779 cites W2907514116 @default.
- W4280516779 cites W2923625930 @default.
- W4280516779 cites W2930326164 @default.
- W4280516779 cites W2936229295 @default.
- W4280516779 cites W2951158909 @default.
- W4280516779 cites W2952303649 @default.
- W4280516779 cites W2969550270 @default.
- W4280516779 cites W2980147288 @default.
- W4280516779 cites W3024379560 @default.
- W4280516779 cites W3036066449 @default.
- W4280516779 cites W3036943149 @default.
- W4280516779 cites W3037137571 @default.
- W4280516779 cites W3082399559 @default.
- W4280516779 cites W3093012048 @default.
- W4280516779 cites W3094231341 @default.
- W4280516779 cites W3097546581 @default.
- W4280516779 cites W3102016493 @default.
- W4280516779 cites W3105901925 @default.
- W4280516779 cites W3109179024 @default.
- W4280516779 cites W3111949720 @default.
- W4280516779 cites W3113146690 @default.
- W4280516779 cites W3118757543 @default.
- W4280516779 cites W3123296823 @default.
- W4280516779 cites W3130507255 @default.
- W4280516779 cites W3152979364 @default.
- W4280516779 cites W3174770650 @default.
- W4280516779 cites W3186200868 @default.
- W4280516779 cites W3187131570 @default.
- W4280516779 cites W3196378402 @default.
- W4280516779 cites W3215841473 @default.
- W4280516779 cites W4239026366 @default.
- W4280516779 cites W97059505 @default.
- W4280516779 doi "https://doi.org/10.3389/fgene.2022.875762" @default.
- W4280516779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35669193" @default.
- W4280516779 hasPublicationYear "2022" @default.
- W4280516779 type Work @default.
- W4280516779 citedByCount "4" @default.
- W4280516779 countsByYear W42805167792022 @default.
- W4280516779 countsByYear W42805167792023 @default.
- W4280516779 crossrefType "journal-article" @default.
- W4280516779 hasAuthorship W4280516779A5003665601 @default.
- W4280516779 hasAuthorship W4280516779A5017737983 @default.
- W4280516779 hasAuthorship W4280516779A5019871897 @default.
- W4280516779 hasAuthorship W4280516779A5020359488 @default.