Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280521208> ?p ?o ?g. }
- W4280521208 endingPage "3827" @default.
- W4280521208 startingPage "3811" @default.
- W4280521208 abstract "The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter cells. Faults in the DDR are a known driver and hallmark of cancer. Furthermore, inhibition of DDR enzymes can be used to treat the disease. This is exemplified by PARP inhibitors (PARPi) used to treat cancers with defects in the homologous recombination DDR pathway. A series of novel DDR targets are now also under pre-clinical or clinical investigation, including inhibitors of ATR kinase, WRN helicase or the DNA polymerase/helicase Polθ (Pol-Theta). Drug resistance is a common phenomenon that impairs the overall effectiveness of cancer treatments and there is already some understanding of how resistance to PARPi occurs. Here, we discuss how an understanding of PARPi resistance could inform how resistance to new drugs targeting the DDR emerges. We also discuss potential strategies that could limit the impact of these therapy resistance mechanisms in cancer." @default.
- W4280521208 created "2022-05-22" @default.
- W4280521208 creator A5023695152 @default.
- W4280521208 creator A5029459932 @default.
- W4280521208 creator A5040450413 @default.
- W4280521208 creator A5059078224 @default.
- W4280521208 date "2022-06-05" @default.
- W4280521208 modified "2023-10-10" @default.
- W4280521208 title "Resistance to <scp>DNA</scp> repair inhibitors in cancer" @default.
- W4280521208 cites W1517472822 @default.
- W4280521208 cites W1538603370 @default.
- W4280521208 cites W1584209245 @default.
- W4280521208 cites W1781764024 @default.
- W4280521208 cites W1826222652 @default.
- W4280521208 cites W1973268287 @default.
- W4280521208 cites W1975141727 @default.
- W4280521208 cites W1975817860 @default.
- W4280521208 cites W1975828432 @default.
- W4280521208 cites W1976924852 @default.
- W4280521208 cites W1982418865 @default.
- W4280521208 cites W1982957001 @default.
- W4280521208 cites W2004718750 @default.
- W4280521208 cites W2009007206 @default.
- W4280521208 cites W2013895149 @default.
- W4280521208 cites W2014588353 @default.
- W4280521208 cites W2014599726 @default.
- W4280521208 cites W2015360671 @default.
- W4280521208 cites W2015616444 @default.
- W4280521208 cites W2020426424 @default.
- W4280521208 cites W2022529631 @default.
- W4280521208 cites W2025350653 @default.
- W4280521208 cites W2028307977 @default.
- W4280521208 cites W2028940434 @default.
- W4280521208 cites W2032210521 @default.
- W4280521208 cites W2034269086 @default.
- W4280521208 cites W2034852369 @default.
- W4280521208 cites W2040860750 @default.
- W4280521208 cites W2043895957 @default.
- W4280521208 cites W2048292104 @default.
- W4280521208 cites W2050128145 @default.
- W4280521208 cites W2050658928 @default.
- W4280521208 cites W2058957446 @default.
- W4280521208 cites W2060329343 @default.
- W4280521208 cites W2064310741 @default.
- W4280521208 cites W2065434335 @default.
- W4280521208 cites W2065588235 @default.
- W4280521208 cites W2065849886 @default.
- W4280521208 cites W2067117419 @default.
- W4280521208 cites W2074730941 @default.
- W4280521208 cites W2076951953 @default.
- W4280521208 cites W2077813812 @default.
- W4280521208 cites W2085639710 @default.
- W4280521208 cites W2086333179 @default.
- W4280521208 cites W2087623507 @default.
- W4280521208 cites W2092536432 @default.
- W4280521208 cites W2096924110 @default.
- W4280521208 cites W2098737737 @default.
- W4280521208 cites W2100525241 @default.
- W4280521208 cites W2102305516 @default.
- W4280521208 cites W2102358336 @default.
- W4280521208 cites W2109518208 @default.
- W4280521208 cites W2109637301 @default.
- W4280521208 cites W2116217779 @default.
- W4280521208 cites W2117692326 @default.
- W4280521208 cites W2128322002 @default.
- W4280521208 cites W2130193848 @default.
- W4280521208 cites W2133106304 @default.
- W4280521208 cites W2140823313 @default.
- W4280521208 cites W2145200068 @default.
- W4280521208 cites W2145264022 @default.
- W4280521208 cites W2145583284 @default.
- W4280521208 cites W2148753835 @default.
- W4280521208 cites W2149515182 @default.
- W4280521208 cites W2154472830 @default.
- W4280521208 cites W2155835896 @default.
- W4280521208 cites W2156647409 @default.
- W4280521208 cites W2160738354 @default.
- W4280521208 cites W2168396953 @default.
- W4280521208 cites W2171972386 @default.
- W4280521208 cites W2173259567 @default.
- W4280521208 cites W2201979800 @default.
- W4280521208 cites W2217722934 @default.
- W4280521208 cites W2260252265 @default.
- W4280521208 cites W2262414037 @default.
- W4280521208 cites W2293220254 @default.
- W4280521208 cites W2320341074 @default.
- W4280521208 cites W2333225812 @default.
- W4280521208 cites W2333415105 @default.
- W4280521208 cites W2341849584 @default.
- W4280521208 cites W2394483225 @default.
- W4280521208 cites W2471011913 @default.
- W4280521208 cites W2476261929 @default.
- W4280521208 cites W2476568892 @default.
- W4280521208 cites W2500891884 @default.
- W4280521208 cites W2511489469 @default.
- W4280521208 cites W2513016538 @default.
- W4280521208 cites W2519980783 @default.
- W4280521208 cites W2530188477 @default.