FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280521512> ?p ?o ?g. }

• W4280521512 abstract "Liver cancer is a highly lethal malignancy. Despite considerable efforts made in recent years, the prognosis of patients with liver cancer remains poor. <em>Curcuma zedoaria</em> (known as Ezhu in Chinese) is widely prescribed in traditional Chinese medicine. Germacrone (GM) is a sesquiterpene constituent derived from the essential oil of Ezhu, and exerts anti‑carcinogenic effects by inducing apoptosis in various cancer cells. The present study investigated the potential mechanism of GM in HepG2 cells. Cell Counting Kit‑8, colony‑formation and lactate dehydrogenase‑release assays, as well as cell death assays using flow cytometry, were performed to evaluate HepG2 cell proliferation following GM treatment. HepG2 cells were transfected with caspase‑3 small interfering RNA and then treated with GM. Caspase‑3 expression levels were determined by reverse transcription‑quantitative PCR and western blotting. The present study showed that GM inhibited the growth of HepG2 cells and induced the proteolytic cleavage of caspase 3, with concomitant cleavage of gasdermin E (GSDME), by markedly increasing the production of reactive oxygen species (ROS). This led to caspase 3‑dependent cleavage of GSDME, thereby promoting pyroptosis in HepG2 cells. However, these changes were rescued by ROS scavengers, such as N‑acetylcysteine. Furthermore, GM inhibited tumor growth by promoting the cleavage of caspase 3 and GSDME in HepG2 cell xenograft models. These results indicated that GM induced GSDME‑dependent pyroptosis through caspase 3 activation, at least in part, by damaging the mitochondria and enhancing ROS production, thereby supporting the possible development of GM as a candidate for the prevention and treatment of liver cancer." @default.
• W4280521512 created "2022-05-22" @default.
• W4280521512 creator A5002957618 @default.
• W4280521512 creator A5004092065 @default.
• W4280521512 creator A5012677271 @default.
• W4280521512 creator A5020504848 @default.
• W4280521512 creator A5037953329 @default.
• W4280521512 creator A5045507934 @default.
• W4280521512 creator A5060050972 @default.
• W4280521512 creator A5066338066 @default.
• W4280521512 creator A5073659985 @default.
• W4280521512 creator A5076723150 @default.
• W4280521512 creator A5087677226 @default.
• W4280521512 date "2022-05-20" @default.
• W4280521512 modified "2023-10-01" @default.
• W4280521512 title "Germacrone induces caspase‑3/GSDME activation and enhances ROS production, causing HepG2 pyroptosis" @default.
• W4280521512 cites W13396403 @default.
• W4280521512 cites W1864325817 @default.
• W4280521512 cites W1912191904 @default.
• W4280521512 cites W1995149018 @default.
• W4280521512 cites W2059008362 @default.
• W4280521512 cites W2087580878 @default.
• W4280521512 cites W2107277218 @default.
• W4280521512 cites W2161531885 @default.
• W4280521512 cites W2192080449 @default.
• W4280521512 cites W2461065450 @default.
• W4280521512 cites W2546915776 @default.
• W4280521512 cites W2560541542 @default.
• W4280521512 cites W2561456541 @default.
• W4280521512 cites W2563886529 @default.
• W4280521512 cites W2608687752 @default.
• W4280521512 cites W2627048017 @default.
• W4280521512 cites W2769622412 @default.
• W4280521512 cites W2770285644 @default.
• W4280521512 cites W2797252933 @default.
• W4280521512 cites W2800141139 @default.
• W4280521512 cites W2888926122 @default.
• W4280521512 cites W2895588157 @default.
• W4280521512 cites W2898332092 @default.
• W4280521512 cites W2901506876 @default.
• W4280521512 cites W2904552328 @default.
• W4280521512 cites W2911884847 @default.
• W4280521512 cites W2917633868 @default.
• W4280521512 cites W2939805948 @default.
• W4280521512 cites W2961112538 @default.
• W4280521512 cites W2978605903 @default.
• W4280521512 cites W2982979216 @default.
• W4280521512 cites W2988033985 @default.
• W4280521512 cites W2989765811 @default.
• W4280521512 cites W3003394636 @default.
• W4280521512 cites W3008585479 @default.
• W4280521512 cites W3011337660 @default.
• W4280521512 cites W3039436229 @default.
• W4280521512 cites W3046132596 @default.
• W4280521512 cites W3081694317 @default.
• W4280521512 cites W3082246186 @default.
• W4280521512 cites W3093045994 @default.
• W4280521512 cites W3095202855 @default.
• W4280521512 cites W3101868257 @default.
• W4280521512 cites W3101908155 @default.
• W4280521512 cites W3108566492 @default.
• W4280521512 cites W3112285889 @default.
• W4280521512 cites W3119175192 @default.
• W4280521512 cites W3122641750 @default.
• W4280521512 cites W3128102381 @default.
• W4280521512 cites W3128646645 @default.
• W4280521512 cites W3153139482 @default.
• W4280521512 doi "https://doi.org/10.3892/etm.2022.11383" @default.
• W4280521512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35747157" @default.
• W4280521512 hasPublicationYear "2022" @default.
• W4280521512 type Work @default.
• W4280521512 citedByCount "9" @default.
• W4280521512 countsByYear W42805215122023 @default.
• W4280521512 crossrefType "journal-article" @default.
• W4280521512 hasAuthorship W4280521512A5002957618 @default.
• W4280521512 hasAuthorship W4280521512A5004092065 @default.
• W4280521512 hasAuthorship W4280521512A5012677271 @default.
• W4280521512 hasAuthorship W4280521512A5020504848 @default.
• W4280521512 hasAuthorship W4280521512A5037953329 @default.
• W4280521512 hasAuthorship W4280521512A5045507934 @default.
• W4280521512 hasAuthorship W4280521512A5060050972 @default.
• W4280521512 hasAuthorship W4280521512A5066338066 @default.
• W4280521512 hasAuthorship W4280521512A5073659985 @default.
• W4280521512 hasAuthorship W4280521512A5076723150 @default.
• W4280521512 hasAuthorship W4280521512A5087677226 @default.
• W4280521512 hasBestOaLocation W42805215121 @default.
• W4280521512 hasConcept C121608353 @default.
• W4280521512 hasConcept C153911025 @default.
• W4280521512 hasConcept C17172800 @default.
• W4280521512 hasConcept C185592680 @default.
• W4280521512 hasConcept C190283241 @default.
• W4280521512 hasConcept C31573885 @default.
• W4280521512 hasConcept C48349386 @default.
• W4280521512 hasConcept C502942594 @default.
• W4280521512 hasConcept C54355233 @default.
• W4280521512 hasConcept C55493867 @default.
• W4280521512 hasConcept C62112901 @default.
• W4280521512 hasConcept C86803240 @default.
• W4280521512 hasConcept C95444343 @default.
• W4280521512 hasConcept C96232424 @default.

• next