FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280521788> ?p ?o ?g. }

• W4280521788 endingPage "366" @default.
• W4280521788 startingPage "361" @default.
• W4280521788 abstract "The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets.We used two data sets for East Asian (EAS) and European (EUR) samples. SCZ data was based on the Psychiatric Genomics Consortium Asia with our own genome-wide association study for EAS and Psychiatric Genomics Consortium for EUR. Nonpsychiatric data (20 binary traits [mainly nonpsychiatric complex disorders] and 34 quantitative traits [mainly laboratory examinations and physical characteristics]) were obtained from Biobank Japan and UK Biobank for EAS and EUR samples, respectively. To evaluate genetic correlation, linkage disequilibrium score regression analysis was utilized with further meta-analysis for each result from EAS and EUR samples to obtain robust evidence. Subsequent mendelian randomization analysis was also included to examine the causal effect.A significant genetic correlation between SCZ and several metabolic syndrome (MetS) traits was detected in the combined samples (meta-analysis between EAS and EUR data) (body mass index [rg = -0.10, q-value = 1.0 × 10-9 ], high-density-lipoprotein cholesterol [rg = 0.072, q-value = 2.9 × 10-3 ], blood sugar [rg = -0.068, q-value = 1.4 × 10-2 ], triglycerides [rg = -0.052, q-value = 2.4 × 10-2 ], systolic blood pressure [rg = -0.054, q-value = 3.5 × 10-2 ], and C-reactive protein [rg = -0.076, q-value = 7.8 × 10-5 ]. However, no causal relationship on SCZ susceptibility was detected for these traits based on the mendelian randomization analysis.Our results indicate shared genetic components between SCZ and MetS traits and C-reactive protein. Specifically, we found it interesting that the correlation between MetS traits and SCZ was the opposite of that expected from clinical studies: this genetic study suggests that SCZ susceptibility was associated with reduced MetS. This implied that MetS in patients with SCZ was not associated with genetic components but with environmental factors, including antipsychotics, lifestyle changes, poor diet, lack of exercise, and living conditions." @default.
• W4280521788 created "2022-05-22" @default.
• W4280521788 creator A5009749245 @default.
• W4280521788 creator A5015137967 @default.
• W4280521788 creator A5036105042 @default.
• W4280521788 creator A5059531186 @default.
• W4280521788 creator A5067300422 @default.
• W4280521788 creator A5072897121 @default.
• W4280521788 creator A5079639326 @default.
• W4280521788 creator A5082871715 @default.
• W4280521788 date "2022-05-30" @default.
• W4280521788 modified "2023-10-18" @default.
• W4280521788 title "Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets" @default.
• W4280521788 cites W1596339956 @default.
• W4280521788 cites W1993397207 @default.
• W4280521788 cites W2014787635 @default.
• W4280521788 cites W2045227722 @default.
• W4280521788 cites W2045384854 @default.
• W4280521788 cites W2048843644 @default.
• W4280521788 cites W2049803576 @default.
• W4280521788 cites W2101357408 @default.
• W4280521788 cites W2119126558 @default.
• W4280521788 cites W2139852368 @default.
• W4280521788 cites W2142862972 @default.
• W4280521788 cites W2148352958 @default.
• W4280521788 cites W2168991266 @default.
• W4280521788 cites W2195783463 @default.
• W4280521788 cites W2340656051 @default.
• W4280521788 cites W2345662338 @default.
• W4280521788 cites W2474672982 @default.
• W4280521788 cites W2520656017 @default.
• W4280521788 cites W2566424235 @default.
• W4280521788 cites W2621274729 @default.
• W4280521788 cites W2742707337 @default.
• W4280521788 cites W2765391558 @default.
• W4280521788 cites W2783223955 @default.
• W4280521788 cites W2796561726 @default.
• W4280521788 cites W2801644518 @default.
• W4280521788 cites W2805983714 @default.
• W4280521788 cites W2889021891 @default.
• W4280521788 cites W2895599024 @default.
• W4280521788 cites W2898901851 @default.
• W4280521788 cites W2951320675 @default.
• W4280521788 cites W2970332657 @default.
• W4280521788 cites W2983765585 @default.
• W4280521788 cites W2995971356 @default.
• W4280521788 cites W2996395690 @default.
• W4280521788 cites W3105331517 @default.
• W4280521788 cites W3127608420 @default.
• W4280521788 cites W3138416446 @default.
• W4280521788 cites W3181124196 @default.
• W4280521788 cites W3184094112 @default.
• W4280521788 cites W3191929891 @default.
• W4280521788 cites W3199344000 @default.
• W4280521788 cites W3204458390 @default.
• W4280521788 cites W3210362739 @default.
• W4280521788 cites W3214366595 @default.
• W4280521788 cites W3217643700 @default.
• W4280521788 cites W910228180 @default.
• W4280521788 doi "https://doi.org/10.1111/pcn.13372" @default.
• W4280521788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35536160" @default.
• W4280521788 hasPublicationYear "2022" @default.
• W4280521788 type Work @default.
• W4280521788 citedByCount "5" @default.
• W4280521788 countsByYear W42805217882022 @default.
• W4280521788 countsByYear W42805217882023 @default.
• W4280521788 crossrefType "journal-article" @default.
• W4280521788 hasAuthorship W4280521788A5009749245 @default.
• W4280521788 hasAuthorship W4280521788A5015137967 @default.
• W4280521788 hasAuthorship W4280521788A5036105042 @default.
• W4280521788 hasAuthorship W4280521788A5059531186 @default.
• W4280521788 hasAuthorship W4280521788A5067300422 @default.
• W4280521788 hasAuthorship W4280521788A5072897121 @default.
• W4280521788 hasAuthorship W4280521788A5079639326 @default.
• W4280521788 hasAuthorship W4280521788A5082871715 @default.
• W4280521788 hasBestOaLocation W42805217881 @default.
• W4280521788 hasConcept C104317684 @default.
• W4280521788 hasConcept C106208931 @default.
• W4280521788 hasConcept C135763542 @default.
• W4280521788 hasConcept C153209595 @default.
• W4280521788 hasConcept C186413461 @default.
• W4280521788 hasConcept C2779901538 @default.
• W4280521788 hasConcept C2993967602 @default.
• W4280521788 hasConcept C54355233 @default.
• W4280521788 hasConcept C68873052 @default.
• W4280521788 hasConcept C70616004 @default.
• W4280521788 hasConcept C86803240 @default.
• W4280521788 hasConceptScore W4280521788C104317684 @default.
• W4280521788 hasConceptScore W4280521788C106208931 @default.
• W4280521788 hasConceptScore W4280521788C135763542 @default.
• W4280521788 hasConceptScore W4280521788C153209595 @default.
• W4280521788 hasConceptScore W4280521788C186413461 @default.
• W4280521788 hasConceptScore W4280521788C2779901538 @default.
• W4280521788 hasConceptScore W4280521788C2993967602 @default.
• W4280521788 hasConceptScore W4280521788C54355233 @default.
• W4280521788 hasConceptScore W4280521788C68873052 @default.
• W4280521788 hasConceptScore W4280521788C70616004 @default.
• W4280521788 hasConceptScore W4280521788C86803240 @default.

• next