FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280521935> ?p ?o ?g. }

• W4280521935 endingPage "5582" @default.
• W4280521935 startingPage "5582" @default.
• W4280521935 abstract "Glucocorticoids (GC) are steroids hormones that drive circulating glucose availability through gluconeogenesis in the liver. However, alternative splicing of the GR mRNA produces two isoforms, termed GRα and GRβ. GRα is the classic receptor that binds to GCs and mediates the most described actions of GCs. GRβ does not bind GCs and acts as a dominant-negative inhibitor of GRα. Moreover, GRβ has intrinsic and GRα-independent transcriptional activity. To date, it remains unknown if GRβ modulates glucose handling in hepatocytes. Therefore, the study aims to characterize the impact of GRβ overexpression on glucose uptake and storage using an in vitro hepatocyte model. Here we show that GRβ overexpression inhibits the induction of gluconeogenic genes by dexamethasone. Moreover, GRβ activates the Akt pathway, increases glucose transports mRNA, increasing glucose uptake and glycogen storage as an insulin-mimetic. Our results suggest that GRβ has agonist-independent insulin-mimetic actions in HepG2 cells." @default.
• W4280521935 created "2022-05-22" @default.
• W4280521935 creator A5017498980 @default.
• W4280521935 creator A5027613461 @default.
• W4280521935 creator A5038458296 @default.
• W4280521935 creator A5045218411 @default.
• W4280521935 creator A5054263598 @default.
• W4280521935 creator A5067277368 @default.
• W4280521935 date "2022-05-17" @default.
• W4280521935 modified "2023-10-14" @default.
• W4280521935 title "Glucocorticoid Receptor β Overexpression Has Agonist-Independent Insulin-Mimetic Effects on HepG2 Glucose Metabolism" @default.
• W4280521935 cites W153393150 @default.
• W4280521935 cites W1582154931 @default.
• W4280521935 cites W1971712880 @default.
• W4280521935 cites W1978393827 @default.
• W4280521935 cites W1980224211 @default.
• W4280521935 cites W2023356552 @default.
• W4280521935 cites W2085617928 @default.
• W4280521935 cites W2107804834 @default.
• W4280521935 cites W2116269912 @default.
• W4280521935 cites W2170096200 @default.
• W4280521935 cites W2180085345 @default.
• W4280521935 cites W2221785436 @default.
• W4280521935 cites W2290824119 @default.
• W4280521935 cites W2543845100 @default.
• W4280521935 cites W2758625405 @default.
• W4280521935 cites W280207433 @default.
• W4280521935 cites W2886865853 @default.
• W4280521935 cites W2959167276 @default.
• W4280521935 cites W3140707757 @default.
• W4280521935 doi "https://doi.org/10.3390/ijms23105582" @default.
• W4280521935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35628392" @default.
• W4280521935 hasPublicationYear "2022" @default.
• W4280521935 type Work @default.
• W4280521935 citedByCount "2" @default.
• W4280521935 countsByYear W42805219352022 @default.
• W4280521935 countsByYear W42805219352023 @default.
• W4280521935 crossrefType "journal-article" @default.
• W4280521935 hasAuthorship W4280521935A5017498980 @default.
• W4280521935 hasAuthorship W4280521935A5027613461 @default.
• W4280521935 hasAuthorship W4280521935A5038458296 @default.
• W4280521935 hasAuthorship W4280521935A5045218411 @default.
• W4280521935 hasAuthorship W4280521935A5054263598 @default.
• W4280521935 hasAuthorship W4280521935A5067277368 @default.
• W4280521935 hasBestOaLocation W42805219351 @default.
• W4280521935 hasConcept C104317684 @default.
• W4280521935 hasConcept C112446052 @default.
• W4280521935 hasConcept C126322002 @default.
• W4280521935 hasConcept C134018914 @default.
• W4280521935 hasConcept C170493617 @default.
• W4280521935 hasConcept C17093226 @default.
• W4280521935 hasConcept C185592680 @default.
• W4280521935 hasConcept C192118531 @default.
• W4280521935 hasConcept C202751555 @default.
• W4280521935 hasConcept C20904676 @default.
• W4280521935 hasConcept C2776200302 @default.
• W4280521935 hasConcept C2777391703 @default.
• W4280521935 hasConcept C2777866211 @default.
• W4280521935 hasConcept C2778938600 @default.
• W4280521935 hasConcept C2779306644 @default.
• W4280521935 hasConcept C2780841215 @default.
• W4280521935 hasConcept C55493867 @default.
• W4280521935 hasConcept C59493245 @default.
• W4280521935 hasConcept C62231903 @default.
• W4280521935 hasConcept C63932345 @default.
• W4280521935 hasConcept C71924100 @default.
• W4280521935 hasConcept C86339819 @default.
• W4280521935 hasConcept C86803240 @default.
• W4280521935 hasConcept C98335778 @default.
• W4280521935 hasConceptScore W4280521935C104317684 @default.
• W4280521935 hasConceptScore W4280521935C112446052 @default.
• W4280521935 hasConceptScore W4280521935C126322002 @default.
• W4280521935 hasConceptScore W4280521935C134018914 @default.
• W4280521935 hasConceptScore W4280521935C170493617 @default.
• W4280521935 hasConceptScore W4280521935C17093226 @default.
• W4280521935 hasConceptScore W4280521935C185592680 @default.
• W4280521935 hasConceptScore W4280521935C192118531 @default.
• W4280521935 hasConceptScore W4280521935C202751555 @default.
• W4280521935 hasConceptScore W4280521935C20904676 @default.
• W4280521935 hasConceptScore W4280521935C2776200302 @default.
• W4280521935 hasConceptScore W4280521935C2777391703 @default.
• W4280521935 hasConceptScore W4280521935C2777866211 @default.
• W4280521935 hasConceptScore W4280521935C2778938600 @default.
• W4280521935 hasConceptScore W4280521935C2779306644 @default.
• W4280521935 hasConceptScore W4280521935C2780841215 @default.
• W4280521935 hasConceptScore W4280521935C55493867 @default.
• W4280521935 hasConceptScore W4280521935C59493245 @default.
• W4280521935 hasConceptScore W4280521935C62231903 @default.
• W4280521935 hasConceptScore W4280521935C63932345 @default.
• W4280521935 hasConceptScore W4280521935C71924100 @default.
• W4280521935 hasConceptScore W4280521935C86339819 @default.
• W4280521935 hasConceptScore W4280521935C86803240 @default.
• W4280521935 hasConceptScore W4280521935C98335778 @default.
• W4280521935 hasFunder F4320334812 @default.
• W4280521935 hasIssue "10" @default.
• W4280521935 hasLocation W42805219351 @default.
• W4280521935 hasLocation W42805219352 @default.
• W4280521935 hasLocation W42805219353 @default.

• next