Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280521985> ?p ?o ?g. }
- W4280521985 endingPage "2181" @default.
- W4280521985 startingPage "2181" @default.
- W4280521985 abstract "Pexa-Vec is an engineered Wyeth-strain vaccinia oncolytic virus (OV), which has been tested extensively in clinical trials, demonstrating enhanced cytotoxic T cell infiltration into tumours following treatment. Favourable immune consequences to Pexa-Vec include the induction of an interferon (IFN) response, followed by inflammatory cytokine/chemokine secretion. This promotes tumour immune infiltration, innate and adaptive immune cell activation and T cell priming, culminating in targeted tumour cell killing, i.e., an immunologically 'cold' tumour microenvironment is transformed into a 'hot' tumour. However, as with all immunotherapies, not all patients respond in a uniformly favourable manner. Our study herein, shows a differential immune response by patients to intravenous Pexa-Vec therapy, whereby some patients responded to the virus in a typical and expected manner, demonstrating a significant IFN induction and subsequent peripheral immune activation. However, other patients experienced a markedly subdued immune response and appeared to exhibit an exhausted phenotype at baseline, characterised by higher baseline immune checkpoint expression and regulatory T cell (Treg) levels. This differential baseline immunological profile accurately predicted the subsequent response to Pexa-Vec and may, therefore, enable the development of predictive biomarkers for Pexa-Vec and OV therapies more widely. If confirmed in larger clinical trials, these immunological biomarkers may enable a personalised approach, whereby patients with an exhausted baseline immune profile are treated with immune checkpoint blockade, with the aim of reversing immune exhaustion, prior to or alongside OV therapy." @default.
- W4280521985 created "2022-05-22" @default.
- W4280521985 creator A5000089296 @default.
- W4280521985 creator A5007919521 @default.
- W4280521985 creator A5017292777 @default.
- W4280521985 creator A5018321708 @default.
- W4280521985 creator A5018551359 @default.
- W4280521985 creator A5029162469 @default.
- W4280521985 creator A5040908788 @default.
- W4280521985 creator A5049291674 @default.
- W4280521985 creator A5068910261 @default.
- W4280521985 creator A5069116024 @default.
- W4280521985 creator A5072528382 @default.
- W4280521985 creator A5073640732 @default.
- W4280521985 creator A5087961238 @default.
- W4280521985 creator A5089143749 @default.
- W4280521985 date "2022-04-27" @default.
- W4280521985 modified "2023-10-10" @default.
- W4280521985 title "Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients" @default.
- W4280521985 cites W1491815146 @default.
- W4280521985 cites W1493283693 @default.
- W4280521985 cites W1493736027 @default.
- W4280521985 cites W1493941926 @default.
- W4280521985 cites W1508220421 @default.
- W4280521985 cites W1508629699 @default.
- W4280521985 cites W1522840247 @default.
- W4280521985 cites W1540592014 @default.
- W4280521985 cites W1565379247 @default.
- W4280521985 cites W1615987345 @default.
- W4280521985 cites W1630245482 @default.
- W4280521985 cites W1643485318 @default.
- W4280521985 cites W1665960652 @default.
- W4280521985 cites W1861735264 @default.
- W4280521985 cites W1891556134 @default.
- W4280521985 cites W1953832000 @default.
- W4280521985 cites W1967684158 @default.
- W4280521985 cites W1968308458 @default.
- W4280521985 cites W1978586979 @default.
- W4280521985 cites W1985444402 @default.
- W4280521985 cites W1990235635 @default.
- W4280521985 cites W2000686840 @default.
- W4280521985 cites W2002589386 @default.
- W4280521985 cites W2005884645 @default.
- W4280521985 cites W2010472544 @default.
- W4280521985 cites W2020849247 @default.
- W4280521985 cites W2039123767 @default.
- W4280521985 cites W2047719515 @default.
- W4280521985 cites W2052707632 @default.
- W4280521985 cites W2063680739 @default.
- W4280521985 cites W2066285532 @default.
- W4280521985 cites W2066906123 @default.
- W4280521985 cites W2067493684 @default.
- W4280521985 cites W2070692423 @default.
- W4280521985 cites W2072448714 @default.
- W4280521985 cites W2075631864 @default.
- W4280521985 cites W2076674654 @default.
- W4280521985 cites W2077781789 @default.
- W4280521985 cites W2089914460 @default.
- W4280521985 cites W2094109570 @default.
- W4280521985 cites W2096232093 @default.
- W4280521985 cites W2097204157 @default.
- W4280521985 cites W2102833781 @default.
- W4280521985 cites W2109485845 @default.
- W4280521985 cites W2115805888 @default.
- W4280521985 cites W2139191751 @default.
- W4280521985 cites W2139397653 @default.
- W4280521985 cites W2144326782 @default.
- W4280521985 cites W2145122687 @default.
- W4280521985 cites W2145321451 @default.
- W4280521985 cites W2149123553 @default.
- W4280521985 cites W2149235787 @default.
- W4280521985 cites W2150594590 @default.
- W4280521985 cites W2161340049 @default.
- W4280521985 cites W2170739773 @default.
- W4280521985 cites W2218652881 @default.
- W4280521985 cites W2248463412 @default.
- W4280521985 cites W2282962877 @default.
- W4280521985 cites W2289712604 @default.
- W4280521985 cites W2301707196 @default.
- W4280521985 cites W2339729906 @default.
- W4280521985 cites W2427476638 @default.
- W4280521985 cites W2529373149 @default.
- W4280521985 cites W2563261123 @default.
- W4280521985 cites W2587876399 @default.
- W4280521985 cites W2602027164 @default.
- W4280521985 cites W2602691345 @default.
- W4280521985 cites W2610932550 @default.
- W4280521985 cites W2750781282 @default.
- W4280521985 cites W2755857262 @default.
- W4280521985 cites W2763265527 @default.
- W4280521985 cites W2799749160 @default.
- W4280521985 cites W2884667904 @default.
- W4280521985 cites W2904099327 @default.
- W4280521985 cites W2925149901 @default.
- W4280521985 doi "https://doi.org/10.3390/cancers14092181" @default.
- W4280521985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35565310" @default.
- W4280521985 hasPublicationYear "2022" @default.
- W4280521985 type Work @default.