FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280522043> ?p ?o ?g. }

• W4280522043 endingPage "871.e7" @default.
• W4280522043 startingPage "871.e1" @default.
• W4280522043 abstract "Extending hormonal intrauterine system duration will allow users to have less need for procedures to provide long-term contraception.This study aimed to evaluate the efficacy and safety of the levonorgestrel 52 mg intrauterine system during years 7 and 8 of use.A total of 1751 nulliparous and multiparous participants aged 16 to 45 years enrolled in a phase 3, multicenter trial to evaluate the efficacy and safety of the use of the Liletta levonorgestrel 52 mg intrauterine system for up to 10 years. Participants aged 36 to 45 years at enrollment underwent safety evaluation only. After the first year, we evaluated participants every 6 months for intrauterine system location confirmation and urine pregnancy testing at each visit. We assessed the Pearl Indices in years 7 and 8 and the life-table analysis for cumulative pregnancy rates through 8 years of use. For the primary efficacy analyses, all participants aged 16 to 35 years at enrollment were included through year 6; years 7 and 8 included only users aged ≤39 years at the start of each use year. Safety outcomes were assessed in all participants regardless of duration of use. We assessed amenorrhea rates, defined as no bleeding or spotting in the 90 days before the end of the year.After intrauterine system placement, we followed 1568 participants aged 16 to 35 years and 146 participants aged 36 to 45 years. The 16- to 35-year-old participants included 986 (57.5%) nulliparous and 433 (25.3%) obese users. Overall, 569 participants started year 7, 478 completed year 7 (380 aged ≤39 years at beginning of year) and 343 completed year 8 (257 aged ≤39 years at beginning of year); 77 completed 10 years of use. Eleven pregnancies occurred over 8 years, 7 (64%) of which were ectopic. Two pregnancies occurred in year 7 (Pearl Index, 0.49; 95% confidence interval, 0.06-1.78), 1 in a participant with implantation 4 days after a desired removal; no pregnancies occurred in year 8. The cumulative life-table pregnancy rate in the primary efficacy population through year 8 was 1.32 (95% confidence interval, 0.69-2.51); without the postremoval pregnancy, the rate was 1.09 (95% confidence interval, 0.56-2.13). Two perforations (0.1%) occurred, none noted after year 1. Expulsion occurred in 71 (4.1%) participants overall, with 3 in year 7 and 2 in year 8. Pelvic infection was diagnosed in 16 (0.9%) participants during intrauterine system use, 1 each in years 7 and 8. Only 44 (2.6%) participants overall discontinued because of bleeding complaints (4 total in years 7 and 8) with rates per year of 0.1% to 0.5% for years 3 to 8. Amenorrhea rates were 39% at both years 7 and 8.The levonorgestrel 52 mg intrauterine system is highly effective over 8 years of use and has an excellent extended safety profile. This report details the longest period of efficacy and safety data for continuous use of a levonorgestrel 52 mg intrauterine system for contraception." @default.
• W4280522043 created "2022-05-22" @default.
• W4280522043 creator A5005089052 @default.
• W4280522043 creator A5018282082 @default.
• W4280522043 creator A5033914030 @default.
• W4280522043 creator A5036543792 @default.
• W4280522043 creator A5040915324 @default.
• W4280522043 creator A5042491895 @default.
• W4280522043 date "2022-12-01" @default.
• W4280522043 modified "2023-10-06" @default.
• W4280522043 title "Levonorgestrel 52 mg intrauterine system efficacy and safety through 8 years of use" @default.
• W4280522043 cites W2002100432 @default.
• W4280522043 cites W2091721910 @default.
• W4280522043 cites W2124714566 @default.
• W4280522043 cites W2140622704 @default.
• W4280522043 cites W2146891180 @default.
• W4280522043 cites W2293102563 @default.
• W4280522043 cites W2342658450 @default.
• W4280522043 cites W2904694102 @default.
• W4280522043 cites W2943668376 @default.
• W4280522043 cites W2990305151 @default.
• W4280522043 doi "https://doi.org/10.1016/j.ajog.2022.05.022" @default.
• W4280522043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35569516" @default.
• W4280522043 hasPublicationYear "2022" @default.
• W4280522043 type Work @default.
• W4280522043 citedByCount "9" @default.
• W4280522043 countsByYear W42805220432022 @default.
• W4280522043 countsByYear W42805220432023 @default.
• W4280522043 crossrefType "journal-article" @default.
• W4280522043 hasAuthorship W4280522043A5005089052 @default.
• W4280522043 hasAuthorship W4280522043A5018282082 @default.
• W4280522043 hasAuthorship W4280522043A5033914030 @default.
• W4280522043 hasAuthorship W4280522043A5036543792 @default.
• W4280522043 hasAuthorship W4280522043A5040915324 @default.
• W4280522043 hasAuthorship W4280522043A5042491895 @default.
• W4280522043 hasBestOaLocation W42805220432 @default.
• W4280522043 hasConcept C131872663 @default.
• W4280522043 hasConcept C2776810592 @default.
• W4280522043 hasConcept C2778058571 @default.
• W4280522043 hasConcept C2779076696 @default.
• W4280522043 hasConcept C2779234561 @default.
• W4280522043 hasConcept C2780186607 @default.
• W4280522043 hasConcept C2908647359 @default.
• W4280522043 hasConcept C29456083 @default.
• W4280522043 hasConcept C2986817661 @default.
• W4280522043 hasConcept C54355233 @default.
• W4280522043 hasConcept C71924100 @default.
• W4280522043 hasConcept C86803240 @default.
• W4280522043 hasConcept C99454951 @default.
• W4280522043 hasConceptScore W4280522043C131872663 @default.
• W4280522043 hasConceptScore W4280522043C2776810592 @default.
• W4280522043 hasConceptScore W4280522043C2778058571 @default.
• W4280522043 hasConceptScore W4280522043C2779076696 @default.
• W4280522043 hasConceptScore W4280522043C2779234561 @default.
• W4280522043 hasConceptScore W4280522043C2780186607 @default.
• W4280522043 hasConceptScore W4280522043C2908647359 @default.
• W4280522043 hasConceptScore W4280522043C29456083 @default.
• W4280522043 hasConceptScore W4280522043C2986817661 @default.
• W4280522043 hasConceptScore W4280522043C54355233 @default.
• W4280522043 hasConceptScore W4280522043C71924100 @default.
• W4280522043 hasConceptScore W4280522043C86803240 @default.
• W4280522043 hasConceptScore W4280522043C99454951 @default.
• W4280522043 hasIssue "6" @default.
• W4280522043 hasLocation W42805220431 @default.
• W4280522043 hasLocation W42805220432 @default.
• W4280522043 hasLocation W42805220433 @default.
• W4280522043 hasOpenAccess W4280522043 @default.
• W4280522043 hasPrimaryLocation W42805220431 @default.
• W4280522043 hasRelatedWork W2043609786 @default.
• W4280522043 hasRelatedWork W2083961731 @default.
• W4280522043 hasRelatedWork W2137349921 @default.
• W4280522043 hasRelatedWork W2141700933 @default.
• W4280522043 hasRelatedWork W2244088791 @default.
• W4280522043 hasRelatedWork W2360041335 @default.
• W4280522043 hasRelatedWork W3013058789 @default.
• W4280522043 hasRelatedWork W4236326720 @default.
• W4280522043 hasRelatedWork W4361981959 @default.
• W4280522043 hasRelatedWork W2610069053 @default.
• W4280522043 hasVolume "227" @default.
• W4280522043 isParatext "false" @default.
• W4280522043 isRetracted "false" @default.
• W4280522043 workType "article" @default.