Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280522068> ?p ?o ?g. }
- W4280522068 abstract "Abstract Immune checkpoint inhibitors (ICIs) have made important breakthrough in anti-tumor therapy, however, no single biomarker can accurately predict their efficacy. Studies have found that tumor microenvironment is a key factor for determining the response to ICI therapy. Cytokine receptor 3 (C-X-C Motif Chemokine Receptor 3, CXCR3) pathway has been reported to play an important role in the migration, activation, and response of immune cells. We analyzed survival data, genomics, and clinical data from patients with metastatic urothelial carcinoma (mUC) who received ICI treatment to explore the relationship between CXCR3 pathway activation and the effectiveness of ICIs. The Cancer Genome Atlas Bladder Urothelial Carcinoma cohort and six other cohorts receiving ICI treatment were used for mechanism exploration and validation. In the ICI cohort, we performed univariate and multivariate COX analyses and discovered that patients in the CXCR3-high group were more sensitive to ICI treatment. A Kaplan–Meier analysis demonstrated that patients in the high CXCR3-high group had a better prognosis than those in the CXCR3-low group (P = 0.0001, Hazard Ratio = 0.56; 95% CI 0.42−0.75). CIBERSORT analysis found that mUC patients in the CXCR3-high group had higher levels of activated CD8+ T cells, M1 macrophages, and activated NK cells and less regulatory T cell (Treg) infiltration. Immunogenicity analysis showed the CXCR3-high group had higher tumor neoantigen burden (TNB). Our study suggests that CXCR3 pathway activation may be a novel predictive biomarker for the effectiveness of immunotherapy in mUC patients." @default.
- W4280522068 created "2022-05-22" @default.
- W4280522068 creator A5004940520 @default.
- W4280522068 creator A5005546204 @default.
- W4280522068 creator A5015950934 @default.
- W4280522068 creator A5029377165 @default.
- W4280522068 creator A5047941899 @default.
- W4280522068 creator A5057209439 @default.
- W4280522068 creator A5061308099 @default.
- W4280522068 creator A5082582836 @default.
- W4280522068 date "2022-05-13" @default.
- W4280522068 modified "2023-10-14" @default.
- W4280522068 title "Activation of the chemokine receptor 3 pathway leads to a better response to immune checkpoint inhibitors in patients with metastatic urothelial carcinoma" @default.
- W4280522068 cites W1966116114 @default.
- W4280522068 cites W1985987855 @default.
- W4280522068 cites W2010457001 @default.
- W4280522068 cites W2028758612 @default.
- W4280522068 cites W2049553585 @default.
- W4280522068 cites W2061990495 @default.
- W4280522068 cites W2071183770 @default.
- W4280522068 cites W2075294566 @default.
- W4280522068 cites W2082393609 @default.
- W4280522068 cites W2097687485 @default.
- W4280522068 cites W2101562875 @default.
- W4280522068 cites W2102116016 @default.
- W4280522068 cites W2103257412 @default.
- W4280522068 cites W2130410032 @default.
- W4280522068 cites W2140980839 @default.
- W4280522068 cites W2148562299 @default.
- W4280522068 cites W2151488185 @default.
- W4280522068 cites W2152796304 @default.
- W4280522068 cites W2159707944 @default.
- W4280522068 cites W2166771618 @default.
- W4280522068 cites W2169831497 @default.
- W4280522068 cites W2179438025 @default.
- W4280522068 cites W2230320310 @default.
- W4280522068 cites W2402673078 @default.
- W4280522068 cites W2406250479 @default.
- W4280522068 cites W2411015969 @default.
- W4280522068 cites W2559804019 @default.
- W4280522068 cites W2560367415 @default.
- W4280522068 cites W2590497374 @default.
- W4280522068 cites W2606495925 @default.
- W4280522068 cites W2611379947 @default.
- W4280522068 cites W2612467560 @default.
- W4280522068 cites W2742952151 @default.
- W4280522068 cites W2760661635 @default.
- W4280522068 cites W2761575992 @default.
- W4280522068 cites W2766922915 @default.
- W4280522068 cites W2778102091 @default.
- W4280522068 cites W2785803176 @default.
- W4280522068 cites W2788097887 @default.
- W4280522068 cites W2788431960 @default.
- W4280522068 cites W2796207838 @default.
- W4280522068 cites W2896872272 @default.
- W4280522068 cites W2899145148 @default.
- W4280522068 cites W2900082702 @default.
- W4280522068 cites W2900657494 @default.
- W4280522068 cites W2909679049 @default.
- W4280522068 cites W2912532602 @default.
- W4280522068 cites W2943108118 @default.
- W4280522068 cites W2945224722 @default.
- W4280522068 cites W2945650981 @default.
- W4280522068 cites W2946348245 @default.
- W4280522068 cites W2947159010 @default.
- W4280522068 cites W2950524924 @default.
- W4280522068 cites W2955269932 @default.
- W4280522068 cites W2965186730 @default.
- W4280522068 cites W2972054455 @default.
- W4280522068 cites W2972475028 @default.
- W4280522068 cites W2972861315 @default.
- W4280522068 cites W2981494293 @default.
- W4280522068 cites W2981790403 @default.
- W4280522068 cites W3002419063 @default.
- W4280522068 cites W3008915658 @default.
- W4280522068 cites W3014027415 @default.
- W4280522068 cites W3023611224 @default.
- W4280522068 cites W3024551702 @default.
- W4280522068 cites W3036531813 @default.
- W4280522068 cites W3036701611 @default.
- W4280522068 cites W3037506839 @default.
- W4280522068 cites W3040360976 @default.
- W4280522068 cites W3041538945 @default.
- W4280522068 cites W3048201207 @default.
- W4280522068 cites W3048849240 @default.
- W4280522068 cites W3049526573 @default.
- W4280522068 cites W3087466624 @default.
- W4280522068 cites W3091811425 @default.
- W4280522068 cites W3098118704 @default.
- W4280522068 cites W3102493364 @default.
- W4280522068 cites W3128131226 @default.
- W4280522068 cites W3153058261 @default.
- W4280522068 cites W3160747615 @default.
- W4280522068 cites W3162328823 @default.
- W4280522068 cites W3164197656 @default.
- W4280522068 cites W3164791653 @default.
- W4280522068 cites W3175752499 @default.
- W4280522068 cites W3183379693 @default.
- W4280522068 cites W3193119005 @default.
- W4280522068 cites W3194506780 @default.