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- W4280523271 endingPage "113204" @default.
- W4280523271 startingPage "113204" @default.
- W4280523271 abstract "Muscle stem cells (MuSCs) are involved in muscle maintenance and regeneration. Mechanically loaded MuSCs within their native niche undergo tensile and shear deformations, but how MuSCs sense mechanical stimuli and translate these into biochemical signals regulating function and fate is still poorly understood. We aimed to investigate whether the glycocalyx is involved in the MuSC mechanoresponse, and whether MuSC morphology affects mechanical loading-induced pressure, shear stress, and fluid velocity distribution. FSS-induced deformation of active proliferating MuSCs (myoblasts) with intact or degraded glycocalyx was assessed by live-cell imaging. Glycocalyx-degradation did not significantly affect nitric oxide production, but reduced FSS-induced myoblast deformation and modulated gene expression. Finite-element analysis revealed that the distribution of FSS-induced pressure, shear stress, and fluid velocity on myoblasts was non-uniform, and the magnitude depended on myoblast morphology and apex-height. In conclusion, our results suggest that the glycocalyx does not play a role in NO production in myoblasts but might impact mechanotransduction and gene expression, which needs further investigation. Future studies will unravel the underlying mechanism by which the glycocalyx affects FSS-induced myoblast deformation, which might be related to increased drag forces. Moreover, MuSCs with varying apex-height experience different levels of FSS-induced pressure, shear stress, and fluid velocity, suggesting differential responsiveness to fluid shear forces." @default.
- W4280523271 created "2022-05-22" @default.
- W4280523271 creator A5000158438 @default.
- W4280523271 creator A5009179841 @default.
- W4280523271 creator A5024298941 @default.
- W4280523271 creator A5037104804 @default.
- W4280523271 creator A5049854527 @default.
- W4280523271 creator A5053866214 @default.
- W4280523271 creator A5060987078 @default.
- W4280523271 creator A5081816088 @default.
- W4280523271 date "2022-08-01" @default.
- W4280523271 modified "2023-10-09" @default.
- W4280523271 title "Fluid shear stress-induced mechanotransduction in myoblasts: Does it depend on the glycocalyx?" @default.
- W4280523271 cites W1012123815 @default.
- W4280523271 cites W1970021366 @default.
- W4280523271 cites W1977481655 @default.
- W4280523271 cites W1978574745 @default.
- W4280523271 cites W1982575302 @default.
- W4280523271 cites W1985617875 @default.
- W4280523271 cites W1985813959 @default.
- W4280523271 cites W1987178519 @default.
- W4280523271 cites W1988107912 @default.
- W4280523271 cites W1988904306 @default.
- W4280523271 cites W1993710877 @default.
- W4280523271 cites W1994566149 @default.
- W4280523271 cites W1995319617 @default.
- W4280523271 cites W1995634506 @default.
- W4280523271 cites W1997131852 @default.
- W4280523271 cites W1997149085 @default.
- W4280523271 cites W1998743787 @default.
- W4280523271 cites W1999622116 @default.
- W4280523271 cites W2003023499 @default.
- W4280523271 cites W2012487210 @default.
- W4280523271 cites W2015638013 @default.
- W4280523271 cites W2027093378 @default.
- W4280523271 cites W2032054380 @default.
- W4280523271 cites W2034248554 @default.
- W4280523271 cites W2034512096 @default.
- W4280523271 cites W2043098612 @default.
- W4280523271 cites W2047136147 @default.
- W4280523271 cites W2052080273 @default.
- W4280523271 cites W2052766715 @default.
- W4280523271 cites W2052977964 @default.
- W4280523271 cites W2055832646 @default.
- W4280523271 cites W2058416225 @default.
- W4280523271 cites W2064902846 @default.
- W4280523271 cites W2067573008 @default.
- W4280523271 cites W2073066886 @default.
- W4280523271 cites W2083693850 @default.
- W4280523271 cites W2084244875 @default.
- W4280523271 cites W2086946136 @default.
- W4280523271 cites W2090588873 @default.
- W4280523271 cites W2098274894 @default.
- W4280523271 cites W2102661335 @default.
- W4280523271 cites W2113401723 @default.
- W4280523271 cites W2114280375 @default.
- W4280523271 cites W2119802842 @default.
- W4280523271 cites W2128650326 @default.
- W4280523271 cites W2128834137 @default.
- W4280523271 cites W2129531991 @default.
- W4280523271 cites W2130809244 @default.
- W4280523271 cites W2137181404 @default.
- W4280523271 cites W2140582490 @default.
- W4280523271 cites W2144751111 @default.
- W4280523271 cites W2145123926 @default.
- W4280523271 cites W2145937652 @default.
- W4280523271 cites W2152252241 @default.
- W4280523271 cites W2179349152 @default.
- W4280523271 cites W2269081530 @default.
- W4280523271 cites W2388738573 @default.
- W4280523271 cites W2473084661 @default.
- W4280523271 cites W2517166961 @default.
- W4280523271 cites W2518585152 @default.
- W4280523271 cites W2527154400 @default.
- W4280523271 cites W2544620354 @default.
- W4280523271 cites W2601343417 @default.
- W4280523271 cites W2610020118 @default.
- W4280523271 cites W2610617838 @default.
- W4280523271 cites W2743055324 @default.
- W4280523271 cites W2757157948 @default.
- W4280523271 cites W2775496369 @default.
- W4280523271 cites W2790156223 @default.
- W4280523271 cites W2793567059 @default.
- W4280523271 cites W2809857463 @default.
- W4280523271 cites W2810766545 @default.
- W4280523271 cites W2897189049 @default.
- W4280523271 cites W2904456109 @default.
- W4280523271 cites W2910948144 @default.
- W4280523271 cites W2926702890 @default.
- W4280523271 cites W2927317830 @default.
- W4280523271 cites W2951171746 @default.
- W4280523271 cites W2952817372 @default.
- W4280523271 cites W2955062442 @default.
- W4280523271 cites W2977831657 @default.
- W4280523271 cites W2982159487 @default.
- W4280523271 cites W2992722040 @default.
- W4280523271 cites W3042756573 @default.
- W4280523271 cites W3044845587 @default.