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• W4280526570 abstract "2,6-Dimethylphenol (2,6-DMP) is an environmental pollutant found in industrial wastewater. Exposure to 2,6-DMP is of increasing concern as it endangered reportedly some aquatic animals. In this study, we investigated the metabolic activation and hepatotoxicity of 2,6-DMP. 2,6-DMP was metabolized to an o-quinone methide intermediate in vitro and in vivo. The electrophilic metabolite was reactive to the sulfhydryl groups of glutathione, N-acetyl cysteine, and cysteine. NADPH was required for the formation of the reactive metabolite. The quinone methide intermediate reacted with cysteine residues to form hepatic protein adduction. A single dose of 2,6-DMP induced marked elevation of serum ALT and AST in mice. Both the protein adduction and hepatotoxicity of 2,6-DMP showed dose dependency." @default.
• W4280526570 created "2022-05-22" @default.
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• W4280526570 date "2022-05-18" @default.
• W4280526570 modified "2023-09-23" @default.
• W4280526570 title "<i>In Vitro</i> and <i>In Vivo</i> Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol" @default.
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• W4280526570 doi "https://doi.org/10.1021/acs.chemrestox.2c00048" @default.
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