Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280531236> ?p ?o ?g. }
- W4280531236 endingPage "153208" @default.
- W4280531236 startingPage "153208" @default.
- W4280531236 abstract "With recent progress in the manufacture and applications of nickel oxide nanoparticles (NiO NPs), concerns about their adverse effects are increasing. Hesperidin (HSP) is a citrus flavonoid that has a potent anti-inflammatory, antioxidant and free radical scavenging activities. This study aims to investigate the protective effect of HSP against testicular and spermatological damages induced by NiO NPs in male rats. Forty rats were randomly and equally divided into four groups: control, NiO NPs, HSP and NiO NPs + HSP. NiO NPs (100 mg/kg) and/or HSP (100 mg/kg) were given daily by gavage for 60 days. Exposure to NiO NPs induced marked reproductive toxicity in male rats that was manifested by increased sperm abnormalities and deterioration of sperm motility, count and viability. NiO NPs also increased lipid peroxidation and negatively affected the cellular antioxidant defense system in the testis of rats. The level of serum testosterone hormone was increased in NiO NPs-exposed rats. qPCR showed a marked downregulation in expression of steroidogenesis-related genes (CYP11A1, HSD3B and STAR) and a significant upregulation in expression of apoptosis-related gene (caspase-9) in testicular tissue of rats. Various pathological lesions and an increase in the number of PCNA-positive immune-reactive cells were also noticed in the testis of NiO NPs-exposed rats. Co-administration of HSP significantly ameliorated most of the NiO NPs-induced testicular damages and improved male fertility in rats." @default.
- W4280531236 created "2022-05-22" @default.
- W4280531236 creator A5001277106 @default.
- W4280531236 creator A5001875248 @default.
- W4280531236 creator A5010837606 @default.
- W4280531236 creator A5013448290 @default.
- W4280531236 creator A5027819734 @default.
- W4280531236 creator A5062056202 @default.
- W4280531236 creator A5085624519 @default.
- W4280531236 creator A5087641087 @default.
- W4280531236 date "2022-05-01" @default.
- W4280531236 modified "2023-09-28" @default.
- W4280531236 title "Alterations in reproductive parameters and steroid biosynthesis induced by nickel oxide nanoparticles in male rats: The ameliorative effect of hesperidin" @default.
- W4280531236 cites W1481433938 @default.
- W4280531236 cites W1736515909 @default.
- W4280531236 cites W1914622032 @default.
- W4280531236 cites W1938462049 @default.
- W4280531236 cites W1965119043 @default.
- W4280531236 cites W1969098903 @default.
- W4280531236 cites W1972039019 @default.
- W4280531236 cites W1972103431 @default.
- W4280531236 cites W1972362525 @default.
- W4280531236 cites W1973136768 @default.
- W4280531236 cites W1974075993 @default.
- W4280531236 cites W1974254997 @default.
- W4280531236 cites W1985690685 @default.
- W4280531236 cites W1998704461 @default.
- W4280531236 cites W2002485211 @default.
- W4280531236 cites W2004469122 @default.
- W4280531236 cites W2008436662 @default.
- W4280531236 cites W2013105209 @default.
- W4280531236 cites W2013870224 @default.
- W4280531236 cites W2014499235 @default.
- W4280531236 cites W2016332054 @default.
- W4280531236 cites W2020599049 @default.
- W4280531236 cites W2022074102 @default.
- W4280531236 cites W2023226705 @default.
- W4280531236 cites W2027293971 @default.
- W4280531236 cites W2042255069 @default.
- W4280531236 cites W2046340162 @default.
- W4280531236 cites W2047529153 @default.
- W4280531236 cites W2049544789 @default.
- W4280531236 cites W2052685651 @default.
- W4280531236 cites W2053717292 @default.
- W4280531236 cites W2053952619 @default.
- W4280531236 cites W2054135032 @default.
- W4280531236 cites W2057889917 @default.
- W4280531236 cites W2068306937 @default.
- W4280531236 cites W2069868341 @default.
- W4280531236 cites W2090929525 @default.
- W4280531236 cites W2095995518 @default.
- W4280531236 cites W2113650514 @default.
- W4280531236 cites W2119924772 @default.
- W4280531236 cites W2121460037 @default.
- W4280531236 cites W2141825656 @default.
- W4280531236 cites W2142489174 @default.
- W4280531236 cites W2162445773 @default.
- W4280531236 cites W2163762391 @default.
- W4280531236 cites W2167689009 @default.
- W4280531236 cites W2172266351 @default.
- W4280531236 cites W2189684077 @default.
- W4280531236 cites W2313334082 @default.
- W4280531236 cites W2333951838 @default.
- W4280531236 cites W2491340588 @default.
- W4280531236 cites W2494923240 @default.
- W4280531236 cites W2602433424 @default.
- W4280531236 cites W2728277928 @default.
- W4280531236 cites W2741969454 @default.
- W4280531236 cites W2922394895 @default.
- W4280531236 cites W2938436980 @default.
- W4280531236 cites W2967932618 @default.
- W4280531236 cites W3036752640 @default.
- W4280531236 cites W3094434203 @default.
- W4280531236 cites W3122740339 @default.
- W4280531236 cites W3137016315 @default.
- W4280531236 cites W3143719576 @default.
- W4280531236 cites W3150452845 @default.
- W4280531236 cites W3174966881 @default.
- W4280531236 cites W3189255408 @default.
- W4280531236 cites W3194750212 @default.
- W4280531236 cites W3195488964 @default.
- W4280531236 cites W3199237051 @default.
- W4280531236 cites W3210531723 @default.
- W4280531236 cites W4229794187 @default.
- W4280531236 cites W4255745765 @default.
- W4280531236 doi "https://doi.org/10.1016/j.tox.2022.153208" @default.
- W4280531236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35569531" @default.
- W4280531236 hasPublicationYear "2022" @default.
- W4280531236 type Work @default.
- W4280531236 citedByCount "8" @default.
- W4280531236 countsByYear W42805312362022 @default.
- W4280531236 countsByYear W42805312362023 @default.
- W4280531236 crossrefType "journal-article" @default.
- W4280531236 hasAuthorship W4280531236A5001277106 @default.
- W4280531236 hasAuthorship W4280531236A5001875248 @default.
- W4280531236 hasAuthorship W4280531236A5010837606 @default.
- W4280531236 hasAuthorship W4280531236A5013448290 @default.
- W4280531236 hasAuthorship W4280531236A5027819734 @default.