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• W4280533276 endingPage "934" @default.
• W4280533276 startingPage "916" @default.
• W4280533276 abstract "Arsenic toxicity is a major concern due to its deleterious consequences for human health. Rapid industrialization also has weakened the quality of the environment by introducing pollutants that may disrupt balanced ecosystems, adversely and irreversibly impacting humans, plants, and animals. Arsenic, an important toxicant among all environmental hazards, can lead to several detrimental effects on cells and organs, impacting the overall quality of life. Nevertheless, arsenic also has a rich history as a chemotherapeutic agent used in ancient days for the treatment of diseases such as malaria, cancer, plague, and syphilis when other chemotherapeutic agents were yet to be discovered. Arsenicosis-mediated disorders remain a serious problem due to the lack of effective therapeutic options. Initially, chelation therapy was used to metabolically eliminate arsenic by forming a complex, but adverse effects limited their pharmacological use. More recently, plant-based products have been found to provide significant relief from the toxic effects of arsenic poisoning. They act by different mechanisms affecting various cellular processes. Phytoconstituents such as curcumin, quercetin, diallyl trisulfide, thymoquinone, and others act via various molecular pathways, primarily by attenuating oxidative damage, membrane damage, DNA damage, and proteinopathies. Nonetheless, most of the phytochemicals reviewed here protect against the adverse effects of metal or metalloid exposure, supporting their consideration as alternatives to chelation therapy. These agents, if used prophylactically and in conjunction with other chemotherapeutic agents, may provide an effective approach for management of arsenic toxicity. In a few instances, such strategies like coadministration of phytochemicals with a known chelating agent have led to more pronounced elimination of arsenic from the body with lesser off-site adverse effects. This is possible because combination treatment ensures the use of a reduced dose of chelating agent with a phytochemical without compromising treatment. Thus, these therapies are more practical than conventional therapeutic agents in ameliorating arsenic-mediated toxicity. This review summarizes the potential of phytochemicals in alleviating arsenic toxicity on the basis of available experimental and clinical evidence." @default.
• W4280533276 created "2022-05-22" @default.
• W4280533276 creator A5014452799 @default.
• W4280533276 creator A5019102184 @default.
• W4280533276 creator A5077025176 @default.
• W4280533276 date "2022-05-16" @default.
• W4280533276 modified "2023-09-27" @default.
• W4280533276 title "Phytochemicals in the Management of Arsenic Toxicity" @default.
• W4280533276 cites W1515393515 @default.
• W4280533276 cites W1539142828 @default.
• W4280533276 cites W1602733564 @default.
• W4280533276 cites W1921050281 @default.
• W4280533276 cites W1929456328 @default.
• W4280533276 cites W1935621077 @default.
• W4280533276 cites W1963740227 @default.
• W4280533276 cites W1966410466 @default.
• W4280533276 cites W1967862890 @default.
• W4280533276 cites W1968342840 @default.
• W4280533276 cites W1970310042 @default.
• W4280533276 cites W1973244492 @default.
• W4280533276 cites W1974924521 @default.
• W4280533276 cites W1976060153 @default.
• W4280533276 cites W1976834502 @default.
• W4280533276 cites W1978321288 @default.
• W4280533276 cites W1980062843 @default.
• W4280533276 cites W1983693425 @default.
• W4280533276 cites W1986093310 @default.
• W4280533276 cites W1988077163 @default.
• W4280533276 cites W1991558153 @default.
• W4280533276 cites W1995043836 @default.
• W4280533276 cites W1995827825 @default.
• W4280533276 cites W1999636687 @default.
• W4280533276 cites W2000519650 @default.
• W4280533276 cites W2006752200 @default.
• W4280533276 cites W2011153200 @default.
• W4280533276 cites W2014099300 @default.
• W4280533276 cites W2015049254 @default.
• W4280533276 cites W2015960085 @default.
• W4280533276 cites W2021625872 @default.
• W4280533276 cites W2022898191 @default.
• W4280533276 cites W2025548522 @default.
• W4280533276 cites W2027307634 @default.
• W4280533276 cites W2027833950 @default.
• W4280533276 cites W2027979481 @default.
• W4280533276 cites W2031558299 @default.
• W4280533276 cites W2032095902 @default.
• W4280533276 cites W2032264019 @default.
• W4280533276 cites W2033998614 @default.
• W4280533276 cites W2037701894 @default.
• W4280533276 cites W2039029820 @default.
• W4280533276 cites W2040533846 @default.
• W4280533276 cites W2042618296 @default.
• W4280533276 cites W2046662981 @default.
• W4280533276 cites W2049265975 @default.
• W4280533276 cites W2049398364 @default.
• W4280533276 cites W2050318470 @default.
• W4280533276 cites W2050587453 @default.
• W4280533276 cites W2050761453 @default.
• W4280533276 cites W2052583992 @default.
• W4280533276 cites W2057672901 @default.
• W4280533276 cites W2058769548 @default.
• W4280533276 cites W2062184988 @default.
• W4280533276 cites W2064060186 @default.
• W4280533276 cites W2069176364 @default.
• W4280533276 cites W2073495046 @default.
• W4280533276 cites W2078769762 @default.
• W4280533276 cites W2081020463 @default.
• W4280533276 cites W2087204302 @default.
• W4280533276 cites W2094818098 @default.
• W4280533276 cites W2097226705 @default.
• W4280533276 cites W2100051347 @default.
• W4280533276 cites W2104311857 @default.
• W4280533276 cites W2107404036 @default.
• W4280533276 cites W2115063820 @default.
• W4280533276 cites W2117800935 @default.
• W4280533276 cites W2124122523 @default.
• W4280533276 cites W2125911539 @default.
• W4280533276 cites W2126757193 @default.
• W4280533276 cites W2127549084 @default.
• W4280533276 cites W2128171074 @default.
• W4280533276 cites W2129397604 @default.
• W4280533276 cites W2132066544 @default.
• W4280533276 cites W2133837654 @default.
• W4280533276 cites W2136185123 @default.
• W4280533276 cites W2141011307 @default.
• W4280533276 cites W2150496093 @default.
• W4280533276 cites W2155507961 @default.
• W4280533276 cites W2157565326 @default.
• W4280533276 cites W2162114270 @default.
• W4280533276 cites W2166447472 @default.
• W4280533276 cites W2167450976 @default.
• W4280533276 cites W2173678367 @default.
• W4280533276 cites W2263929825 @default.
• W4280533276 cites W2299154318 @default.
• W4280533276 cites W2301597928 @default.
• W4280533276 cites W2312762415 @default.
• W4280533276 cites W2319873955 @default.
• W4280533276 cites W2323175697 @default.

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