Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280533767> ?p ?o ?g. }
- W4280533767 abstract "Abstract In mammals, sperm acquire fertilization ability after a series of physiological and biochemical changes, collectively known as capacitation, that occur inside the female reproductive tract. In addition to other requirements, sperm bioenergetic metabolism has been identified as fundamental component in the acquisition of the capacitated status. Mammalian sperm produce ATP by means of two main metabolic processes, oxidative phosphorylation (OXPHOS) and aerobic glycolysis, that are localized in two different flagellar compartments, midpiece and principal piece, respectively. In mouse sperm, the occurrence of many events associated to capacitation depends on the activity of these two energy-producing pathways, leading to the hypothesis that some of these events may impose changes in sperm energetic demands. In the present study, we used extracellular flux analysis to evaluate the changes in the glycolytic and respiratory parameters of murine sperm that occur as a consequence of capacitation. Furthermore, we examined whether these variations affect sperm ATP sustainability. Our results show that capacitation promotes a shift in the usage ratio of the two main metabolic pathways, from oxidative to glycolytic. However, this metabolic rewiring does not seem to affect the rate at which the sperm consume ATP. We conclude that the probable function of the metabolic switch is to increase the ATP supply in the distal flagellar regions, thus sustaining the energetic demands that arise from capacitation." @default.
- W4280533767 created "2022-05-22" @default.
- W4280533767 creator A5039058754 @default.
- W4280533767 creator A5042487836 @default.
- W4280533767 creator A5050359667 @default.
- W4280533767 creator A5062758530 @default.
- W4280533767 date "2022-05-08" @default.
- W4280533767 modified "2023-10-17" @default.
- W4280533767 title "Capacitation promotes a shift in the energy metabolism in murine sperm" @default.
- W4280533767 cites W1520897616 @default.
- W4280533767 cites W1531722346 @default.
- W4280533767 cites W1570735806 @default.
- W4280533767 cites W1579924187 @default.
- W4280533767 cites W1754899866 @default.
- W4280533767 cites W1842647761 @default.
- W4280533767 cites W1870184698 @default.
- W4280533767 cites W1883492035 @default.
- W4280533767 cites W1921163666 @default.
- W4280533767 cites W1922120593 @default.
- W4280533767 cites W1970712654 @default.
- W4280533767 cites W1971335425 @default.
- W4280533767 cites W1974331365 @default.
- W4280533767 cites W1979091525 @default.
- W4280533767 cites W1981905015 @default.
- W4280533767 cites W1982130096 @default.
- W4280533767 cites W1987230338 @default.
- W4280533767 cites W1987949641 @default.
- W4280533767 cites W1990631708 @default.
- W4280533767 cites W1992308074 @default.
- W4280533767 cites W1992466559 @default.
- W4280533767 cites W1996182513 @default.
- W4280533767 cites W1997295104 @default.
- W4280533767 cites W2005818470 @default.
- W4280533767 cites W2006159306 @default.
- W4280533767 cites W2013627967 @default.
- W4280533767 cites W2014421381 @default.
- W4280533767 cites W2016738037 @default.
- W4280533767 cites W2019868877 @default.
- W4280533767 cites W2020539201 @default.
- W4280533767 cites W2021294944 @default.
- W4280533767 cites W2025945521 @default.
- W4280533767 cites W2040080912 @default.
- W4280533767 cites W2041042487 @default.
- W4280533767 cites W2045560456 @default.
- W4280533767 cites W2052373312 @default.
- W4280533767 cites W2063894880 @default.
- W4280533767 cites W2075520844 @default.
- W4280533767 cites W2075535173 @default.
- W4280533767 cites W2078177070 @default.
- W4280533767 cites W2087532217 @default.
- W4280533767 cites W2088265030 @default.
- W4280533767 cites W2090780762 @default.
- W4280533767 cites W2095581618 @default.
- W4280533767 cites W2105914979 @default.
- W4280533767 cites W2106521012 @default.
- W4280533767 cites W2106822387 @default.
- W4280533767 cites W2110744500 @default.
- W4280533767 cites W2112523892 @default.
- W4280533767 cites W2113256043 @default.
- W4280533767 cites W2118233937 @default.
- W4280533767 cites W2118802683 @default.
- W4280533767 cites W2134928968 @default.
- W4280533767 cites W2135863513 @default.
- W4280533767 cites W2137175990 @default.
- W4280533767 cites W2138995199 @default.
- W4280533767 cites W2142236650 @default.
- W4280533767 cites W2143505819 @default.
- W4280533767 cites W2143648130 @default.
- W4280533767 cites W2144346537 @default.
- W4280533767 cites W2147858742 @default.
- W4280533767 cites W2154033142 @default.
- W4280533767 cites W2156054328 @default.
- W4280533767 cites W2157088514 @default.
- W4280533767 cites W2158389479 @default.
- W4280533767 cites W2161126390 @default.
- W4280533767 cites W2166446009 @default.
- W4280533767 cites W2166599095 @default.
- W4280533767 cites W2182922703 @default.
- W4280533767 cites W2313372982 @default.
- W4280533767 cites W2343144239 @default.
- W4280533767 cites W2343477951 @default.
- W4280533767 cites W2464760374 @default.
- W4280533767 cites W2468149186 @default.
- W4280533767 cites W2471501365 @default.
- W4280533767 cites W2486742138 @default.
- W4280533767 cites W2587747364 @default.
- W4280533767 cites W2735590725 @default.
- W4280533767 cites W2890605109 @default.
- W4280533767 cites W2896610371 @default.
- W4280533767 cites W2951104254 @default.
- W4280533767 cites W2951717324 @default.
- W4280533767 cites W2979751059 @default.
- W4280533767 cites W3025565507 @default.
- W4280533767 cites W3038887784 @default.
- W4280533767 cites W3081512638 @default.
- W4280533767 cites W3084553484 @default.
- W4280533767 cites W3097406743 @default.
- W4280533767 cites W3113834486 @default.
- W4280533767 cites W3202722362 @default.
- W4280533767 cites W3210283221 @default.