FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280533884> ?p ?o ?g. }

• W4280533884 endingPage "109128" @default.
• W4280533884 startingPage "109128" @default.
• W4280533884 abstract "Our previous study suggested that inhibition of Phosphodiesterase 2 ameliorates memory loss upon exposure to oxidative stress. While whether memory enhancing effects of PDE2 inhibition on Alzheimer's disease mouse model are involved in antioxidant defense and neuronal remodeling, are largely unexplored. The present study addressed whether and how PDE2 inhibitor Bay 60–7550 rescued Aβ oligomers (Aβo)-induced neuronal damage and memory impairment. The results suggested that exposure of primary cortical neurons to Aβo induced neuronal cells damage and increased PDE2 expression, which were paralleled to an increase in the oxidative parameter malondialdehyde (MDA) level and cellular apoptosis. However, this Aβo-induced oxidative damage was blocked by pre-treatment with protein kinase A or G (PKA or PKG) inhibitor, suggesting the involvement of cAMP/cGMP signaling. Moreover, microinjection of Aβo into the prefrontal cortex of mice increased the MDA level; while Bay 60–7550 reversed this effect and increased antioxidant and anti-apoptotic factors, i.e. increased trolox-equivalent-antioxidant capacity and Bcl-2/Bax ratio. Bay 60–7550 also rescued Aβo-induced synaptic atrophy and memory deficits, as evidenced by the increased synaptic proteins' levels and spine density in the prefrontal cortex, and improved cognitive behaviors by decreased working memory errors in the eight-arm maze and increased discrimination index in the novel object recognition test. These findings suggest that inhibition of PDE2 contributes to antioxidant defense and neuronal remodeling by regulation of cAMP/cGMP signaling, which provide a theoretical basis for the future use of PDE2 inhibitors as the anti-AD drugs." @default.
• W4280533884 created "2022-05-22" @default.
• W4280533884 creator A5022502790 @default.
• W4280533884 creator A5031447561 @default.
• W4280533884 creator A5034516493 @default.
• W4280533884 creator A5037049534 @default.
• W4280533884 creator A5044104772 @default.
• W4280533884 creator A5051639739 @default.
• W4280533884 creator A5052768034 @default.
• W4280533884 creator A5055143937 @default.
• W4280533884 creator A5055440524 @default.
• W4280533884 creator A5066595006 @default.
• W4280533884 creator A5071772212 @default.
• W4280533884 date "2022-08-01" @default.
• W4280533884 modified "2023-09-30" @default.
• W4280533884 title "Protective effects of phosphodiesterase 2 inhibitor against Aβ1-42 induced neuronal toxicity" @default.
• W4280533884 cites W1534741345 @default.
• W4280533884 cites W1634968545 @default.
• W4280533884 cites W1911444796 @default.
• W4280533884 cites W1960689142 @default.
• W4280533884 cites W1968602836 @default.
• W4280533884 cites W1976624715 @default.
• W4280533884 cites W1982998929 @default.
• W4280533884 cites W1983668432 @default.
• W4280533884 cites W1988214498 @default.
• W4280533884 cites W1990382521 @default.
• W4280533884 cites W2009833394 @default.
• W4280533884 cites W2012638305 @default.
• W4280533884 cites W2019521819 @default.
• W4280533884 cites W2020788145 @default.
• W4280533884 cites W2023983537 @default.
• W4280533884 cites W2025868648 @default.
• W4280533884 cites W2035384082 @default.
• W4280533884 cites W2044191726 @default.
• W4280533884 cites W2049947409 @default.
• W4280533884 cites W2070016770 @default.
• W4280533884 cites W2073077045 @default.
• W4280533884 cites W2074161297 @default.
• W4280533884 cites W2084593700 @default.
• W4280533884 cites W2086281632 @default.
• W4280533884 cites W2117445070 @default.
• W4280533884 cites W2123384830 @default.
• W4280533884 cites W2124493262 @default.
• W4280533884 cites W2131865492 @default.
• W4280533884 cites W2145989836 @default.
• W4280533884 cites W2158748165 @default.
• W4280533884 cites W2162169097 @default.
• W4280533884 cites W2413972541 @default.
• W4280533884 cites W2568450381 @default.
• W4280533884 cites W2727482315 @default.
• W4280533884 cites W2755974878 @default.
• W4280533884 cites W2758714921 @default.
• W4280533884 cites W2789253060 @default.
• W4280533884 cites W2801469852 @default.
• W4280533884 cites W2892754564 @default.
• W4280533884 cites W2897635829 @default.
• W4280533884 cites W2940731468 @default.
• W4280533884 cites W2947302792 @default.
• W4280533884 cites W2978068959 @default.
• W4280533884 cites W3082127917 @default.
• W4280533884 cites W3112948680 @default.
• W4280533884 doi "https://doi.org/10.1016/j.neuropharm.2022.109128" @default.
• W4280533884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35588859" @default.
• W4280533884 hasPublicationYear "2022" @default.
• W4280533884 type Work @default.
• W4280533884 citedByCount "0" @default.
• W4280533884 crossrefType "journal-article" @default.
• W4280533884 hasAuthorship W4280533884A5022502790 @default.
• W4280533884 hasAuthorship W4280533884A5031447561 @default.
• W4280533884 hasAuthorship W4280533884A5034516493 @default.
• W4280533884 hasAuthorship W4280533884A5037049534 @default.
• W4280533884 hasAuthorship W4280533884A5044104772 @default.
• W4280533884 hasAuthorship W4280533884A5051639739 @default.
• W4280533884 hasAuthorship W4280533884A5052768034 @default.
• W4280533884 hasAuthorship W4280533884A5055143937 @default.
• W4280533884 hasAuthorship W4280533884A5055440524 @default.
• W4280533884 hasAuthorship W4280533884A5066595006 @default.
• W4280533884 hasAuthorship W4280533884A5071772212 @default.
• W4280533884 hasBestOaLocation W42805338841 @default.
• W4280533884 hasConcept C169760540 @default.
• W4280533884 hasConcept C181199279 @default.
• W4280533884 hasConcept C185592680 @default.
• W4280533884 hasConcept C25498285 @default.
• W4280533884 hasConcept C2776151105 @default.
• W4280533884 hasConcept C2776231299 @default.
• W4280533884 hasConcept C2776766087 @default.
• W4280533884 hasConcept C2778004101 @default.
• W4280533884 hasConcept C2993539680 @default.
• W4280533884 hasConcept C55493867 @default.
• W4280533884 hasConcept C62826618 @default.
• W4280533884 hasConcept C86803240 @default.
• W4280533884 hasConcept C98274493 @default.
• W4280533884 hasConceptScore W4280533884C169760540 @default.
• W4280533884 hasConceptScore W4280533884C181199279 @default.
• W4280533884 hasConceptScore W4280533884C185592680 @default.
• W4280533884 hasConceptScore W4280533884C25498285 @default.
• W4280533884 hasConceptScore W4280533884C2776151105 @default.
• W4280533884 hasConceptScore W4280533884C2776231299 @default.

• next