FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280536714> ?p ?o ?g. }

• W4280536714 endingPage "e060869" @default.
• W4280536714 startingPage "e060869" @default.
• W4280536714 abstract "Gender affirming hormone therapy (GAHT) is increasingly used by transgender individuals and leads to shifts in sex hormone levels. Skeletal muscle is highly responsive to hormone activity, with limited data on the effects of GAHT on different human tissues. Here, we present the protocol for the GAME study (the effects of Gender Affirming hormone therapy on skeletal Muscle training and Epigenetics), which aims to uncover the effects of GAHT on skeletal muscle 'omic' profiles (methylomics, transcriptomics, proteomics, metabolomics) and markers of skeletal muscle health and fitness.This study is a prospective age-matched cohort study in transgender adults commencing GAHT (n=80) and age-matched individuals not commencing GAHT (n=80), conducted at Austin Health and Victoria University in Victoria, Australia. Assessments will take place prior to beginning GAHT and 6 and 12 months into therapies in adults commencing GAHT. Age-matched individuals will be assessed at the same time points. Assessments will be divided over three examination days, involving (1) aerobic fitness tests, (2) muscle strength assessments and (3) collection of blood and muscle samples, as well as body composition measurements. Standardised diets, fitness watches and questionnaires will be used to control for key confounders in analyses. Primary outcomes are changes in aerobic fitness and muscle strength, as well as changes in skeletal muscle DNA methylation and gene expression profiles. Secondary outcomes include changes in skeletal muscle characteristics, proteomics, body composition and blood markers. Linear mixed models will be used to assess changes in outcomes, while accounting for repeated measures within participants and adjusting for known confounders.The Austin Health Human Research Ethics Committee (HREC) and Victoria University HREC granted approval for this study (HREC/77146/Austin-2021). Findings from this project will be published in open-access, peer-reviewed journals and presented to scientific and public audiences.ACTRN12621001415897; Pre-results." @default.
• W4280536714 created "2022-05-22" @default.
• W4280536714 creator A5004379567 @default.
• W4280536714 creator A5014052957 @default.
• W4280536714 creator A5015015165 @default.
• W4280536714 creator A5015479543 @default.
• W4280536714 creator A5015890840 @default.
• W4280536714 creator A5022292202 @default.
• W4280536714 creator A5030550055 @default.
• W4280536714 creator A5031900918 @default.
• W4280536714 creator A5038538003 @default.
• W4280536714 creator A5047591490 @default.
• W4280536714 creator A5052288875 @default.
• W4280536714 creator A5052613903 @default.
• W4280536714 creator A5070747906 @default.
• W4280536714 creator A5073223744 @default.
• W4280536714 creator A5079613388 @default.
• W4280536714 creator A5090521105 @default.
• W4280536714 creator A5091407132 @default.
• W4280536714 date "2022-05-01" @default.
• W4280536714 modified "2023-10-15" @default.
• W4280536714 title "Uncovering the effects of gender affirming hormone therapy on skeletal muscle and epigenetics: protocol for a prospective matched cohort study in transgender individuals (the GAME study)" @default.
• W4280536714 cites W1968559399 @default.
• W4280536714 cites W1982304489 @default.
• W4280536714 cites W2043790950 @default.
• W4280536714 cites W2048984588 @default.
• W4280536714 cites W2061337801 @default.
• W4280536714 cites W2077474440 @default.
• W4280536714 cites W2089165963 @default.
• W4280536714 cites W2155094087 @default.
• W4280536714 cites W2167851640 @default.
• W4280536714 cites W2262352538 @default.
• W4280536714 cites W2394924422 @default.
• W4280536714 cites W2548724077 @default.
• W4280536714 cites W2615015907 @default.
• W4280536714 cites W2751933586 @default.
• W4280536714 cites W2765605718 @default.
• W4280536714 cites W2768793118 @default.
• W4280536714 cites W2772062707 @default.
• W4280536714 cites W2863221561 @default.
• W4280536714 cites W2883088360 @default.
• W4280536714 cites W2887008427 @default.
• W4280536714 cites W2889930586 @default.
• W4280536714 cites W2905599330 @default.
• W4280536714 cites W2911983681 @default.
• W4280536714 cites W2935861759 @default.
• W4280536714 cites W2953432407 @default.
• W4280536714 cites W2963163130 @default.
• W4280536714 cites W2965815274 @default.
• W4280536714 cites W2967714070 @default.
• W4280536714 cites W2988177601 @default.
• W4280536714 cites W2992734117 @default.
• W4280536714 cites W3006710225 @default.
• W4280536714 cites W3008458314 @default.
• W4280536714 cites W3025565106 @default.
• W4280536714 cites W3040549096 @default.
• W4280536714 cites W3043322345 @default.
• W4280536714 cites W3080426358 @default.
• W4280536714 cites W3096104063 @default.
• W4280536714 cites W3112829617 @default.
• W4280536714 cites W3122235975 @default.
• W4280536714 cites W3134761747 @default.
• W4280536714 cites W3156335300 @default.
• W4280536714 cites W3178081825 @default.
• W4280536714 cites W4220772938 @default.
• W4280536714 doi "https://doi.org/10.1136/bmjopen-2022-060869" @default.
• W4280536714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35545400" @default.
• W4280536714 hasPublicationYear "2022" @default.
• W4280536714 type Work @default.
• W4280536714 citedByCount "4" @default.
• W4280536714 countsByYear W42805367142022 @default.
• W4280536714 countsByYear W42805367142023 @default.
• W4280536714 crossrefType "journal-article" @default.
• W4280536714 hasAuthorship W4280536714A5004379567 @default.
• W4280536714 hasAuthorship W4280536714A5014052957 @default.
• W4280536714 hasAuthorship W4280536714A5015015165 @default.
• W4280536714 hasAuthorship W4280536714A5015479543 @default.
• W4280536714 hasAuthorship W4280536714A5015890840 @default.
• W4280536714 hasAuthorship W4280536714A5022292202 @default.
• W4280536714 hasAuthorship W4280536714A5030550055 @default.
• W4280536714 hasAuthorship W4280536714A5031900918 @default.
• W4280536714 hasAuthorship W4280536714A5038538003 @default.
• W4280536714 hasAuthorship W4280536714A5047591490 @default.
• W4280536714 hasAuthorship W4280536714A5052288875 @default.
• W4280536714 hasAuthorship W4280536714A5052613903 @default.
• W4280536714 hasAuthorship W4280536714A5070747906 @default.
• W4280536714 hasAuthorship W4280536714A5073223744 @default.
• W4280536714 hasAuthorship W4280536714A5079613388 @default.
• W4280536714 hasAuthorship W4280536714A5090521105 @default.
• W4280536714 hasAuthorship W4280536714A5091407132 @default.
• W4280536714 hasBestOaLocation W42805367141 @default.
• W4280536714 hasConcept C104317684 @default.
• W4280536714 hasConcept C126322002 @default.
• W4280536714 hasConcept C171687745 @default.
• W4280536714 hasConcept C1862650 @default.
• W4280536714 hasConcept C188816634 @default.
• W4280536714 hasConcept C2779959927 @default.
• W4280536714 hasConcept C41091548 @default.

• next