FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280537112> ?p ?o ?g. }

• W4280537112 abstract "Abstract The development and spread of drug resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require intensive preclinical studies to determine optimal combination and dosing regimens. To support the selection of new combinations, we developed a novel in vitro-in silico combination approach to help identify the pharmacodynamic interactions of the two antimalarial drugs which can be plugged into a pharmacokinetic/pharmacodynamic model built with human monotherapies parasitological data to predict the parasitological endpoints of the combination. This allows to optimally select drug combinations and doses for the clinical development of antimalarials. With this assay, we successfully predicted the endpoints of two phase 2 clinical trials in patients with the artefenomel - piperaquine and artefenomel - ferroquine drug combinations. Besides, the predictive performance of our novel in vitro model was equivalent to the humanized mouse model outcome. Lastly, our more granular in vitro combination assay provided additional insights into the pharmacodynamic drug interactions compared to the in vivo systems, e.g. a concentration-dependent change in the E max and the EC 50 values of piperaquine or artefenomel or a directional reduction of the EC 50 of ferroquine by artefenomel and a directional reduction of E max of ferroquine by artefenomel. Overall, this novel in vitro-in silico -based technology will significantly improve and streamline the economic development of new drug combinations in malaria and potentially also in other therapeutic areas." @default.
• W4280537112 created "2022-05-22" @default.
• W4280537112 creator A5009793209 @default.
• W4280537112 creator A5020772864 @default.
• W4280537112 creator A5023601169 @default.
• W4280537112 creator A5038323169 @default.
• W4280537112 creator A5046140216 @default.
• W4280537112 creator A5058084274 @default.
• W4280537112 creator A5064772116 @default.
• W4280537112 creator A5069423489 @default.
• W4280537112 creator A5079355064 @default.
• W4280537112 creator A5080659713 @default.
• W4280537112 date "2022-04-21" @default.
• W4280537112 modified "2023-10-16" @default.
• W4280537112 title "A new <i>in vitro</i> checkerboard-parasite reduction ratio interaction assay for early de-risk of clinical development of antimalarial combinations" @default.
• W4280537112 cites W1969503178 @default.
• W4280537112 cites W1972907204 @default.
• W4280537112 cites W2000518631 @default.
• W4280537112 cites W2003127960 @default.
• W4280537112 cites W2065314419 @default.
• W4280537112 cites W2070778360 @default.
• W4280537112 cites W2086012629 @default.
• W4280537112 cites W2090155474 @default.
• W4280537112 cites W2116952919 @default.
• W4280537112 cites W2122405690 @default.
• W4280537112 cites W2125634319 @default.
• W4280537112 cites W2126231318 @default.
• W4280537112 cites W2130533265 @default.
• W4280537112 cites W2144450303 @default.
• W4280537112 cites W2155796970 @default.
• W4280537112 cites W2156003764 @default.
• W4280537112 cites W2161798663 @default.
• W4280537112 cites W2311206212 @default.
• W4280537112 cites W2565120106 @default.
• W4280537112 cites W2610213802 @default.
• W4280537112 cites W2763987310 @default.
• W4280537112 cites W2773092701 @default.
• W4280537112 cites W2808371897 @default.
• W4280537112 cites W3004689665 @default.
• W4280537112 cites W3012611966 @default.
• W4280537112 cites W3095233190 @default.
• W4280537112 cites W3127972053 @default.
• W4280537112 cites W3162498666 @default.
• W4280537112 doi "https://doi.org/10.1101/2022.04.19.488858" @default.
• W4280537112 hasPublicationYear "2022" @default.
• W4280537112 type Work @default.
• W4280537112 citedByCount "1" @default.
• W4280537112 countsByYear W42805371122022 @default.
• W4280537112 crossrefType "posted-content" @default.
• W4280537112 hasAuthorship W4280537112A5009793209 @default.
• W4280537112 hasAuthorship W4280537112A5020772864 @default.
• W4280537112 hasAuthorship W4280537112A5023601169 @default.
• W4280537112 hasAuthorship W4280537112A5038323169 @default.
• W4280537112 hasAuthorship W4280537112A5046140216 @default.
• W4280537112 hasAuthorship W4280537112A5058084274 @default.
• W4280537112 hasAuthorship W4280537112A5064772116 @default.
• W4280537112 hasAuthorship W4280537112A5069423489 @default.
• W4280537112 hasAuthorship W4280537112A5079355064 @default.
• W4280537112 hasAuthorship W4280537112A5080659713 @default.
• W4280537112 hasBestOaLocation W42805371121 @default.
• W4280537112 hasConcept C104317684 @default.
• W4280537112 hasConcept C111113717 @default.
• W4280537112 hasConcept C112705442 @default.
• W4280537112 hasConcept C150903083 @default.
• W4280537112 hasConcept C203014093 @default.
• W4280537112 hasConcept C207001950 @default.
• W4280537112 hasConcept C2775905019 @default.
• W4280537112 hasConcept C2776120307 @default.
• W4280537112 hasConcept C2776999253 @default.
• W4280537112 hasConcept C2777288759 @default.
• W4280537112 hasConcept C2777616469 @default.
• W4280537112 hasConcept C2778048844 @default.
• W4280537112 hasConcept C2778371730 @default.
• W4280537112 hasConcept C2780035454 @default.
• W4280537112 hasConcept C55493867 @default.
• W4280537112 hasConcept C64903051 @default.
• W4280537112 hasConcept C71924100 @default.
• W4280537112 hasConcept C86803240 @default.
• W4280537112 hasConcept C98274493 @default.
• W4280537112 hasConceptScore W4280537112C104317684 @default.
• W4280537112 hasConceptScore W4280537112C111113717 @default.
• W4280537112 hasConceptScore W4280537112C112705442 @default.
• W4280537112 hasConceptScore W4280537112C150903083 @default.
• W4280537112 hasConceptScore W4280537112C203014093 @default.
• W4280537112 hasConceptScore W4280537112C207001950 @default.
• W4280537112 hasConceptScore W4280537112C2775905019 @default.
• W4280537112 hasConceptScore W4280537112C2776120307 @default.
• W4280537112 hasConceptScore W4280537112C2776999253 @default.
• W4280537112 hasConceptScore W4280537112C2777288759 @default.
• W4280537112 hasConceptScore W4280537112C2777616469 @default.
• W4280537112 hasConceptScore W4280537112C2778048844 @default.
• W4280537112 hasConceptScore W4280537112C2778371730 @default.
• W4280537112 hasConceptScore W4280537112C2780035454 @default.
• W4280537112 hasConceptScore W4280537112C55493867 @default.
• W4280537112 hasConceptScore W4280537112C64903051 @default.
• W4280537112 hasConceptScore W4280537112C71924100 @default.
• W4280537112 hasConceptScore W4280537112C86803240 @default.
• W4280537112 hasConceptScore W4280537112C98274493 @default.
• W4280537112 hasLocation W42805371121 @default.
• W4280537112 hasOpenAccess W4280537112 @default.

• next