Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280537707> ?p ?o ?g. }
- W4280537707 endingPage "501" @default.
- W4280537707 startingPage "490" @default.
- W4280537707 abstract "Thermosensitive bioadhesive formulations can display increased retention time, skin permeation, and improve the topical therapy of many drugs. Acne is an inflammatory process triggered by several factors like the proliferation of the bacteria Propionibacterium acnes. Aiming for a new alternative treatment with a natural source, propolis displays great potential due to its antibiotic, anti-inflammatory, and healing properties. This study describes the development of bioadhesive thermoresponsive platform with cellulose derivatives and poloxamer 407 for propolis skin delivery. Propolis ethanolic extract (PES) was added to the formulations with sodium carboxymethylcellulose (CMC) or hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (Polox). The formulations were characterized as rheology, bioadhesion, and mechanical analysis. The selected formulations were investigated as in vitro propolis release, cytotoxicity, ex vivo skin permeation by Fourier Transform Infrared Photoacoustic Spectroscopy, and the activity against P. acnes. Formulations showed suitable sol-gel transition temperature, shear-thinning behavior, and texture profile. CMC presence decreased the cohesiveness and adhesiveness of formulations. Polox/HPMC/PES system displayed less cytotoxicity, modified propolis release governed by anomalous transport, skin permeation, and activity against P. acnes. These results indicate important advantages in the topical treatment of acne and suggest a potential formulation for clinical evaluation." @default.
- W4280537707 created "2022-05-22" @default.
- W4280537707 creator A5003626587 @default.
- W4280537707 creator A5006984732 @default.
- W4280537707 creator A5011603327 @default.
- W4280537707 creator A5021584937 @default.
- W4280537707 creator A5033111944 @default.
- W4280537707 creator A5045754640 @default.
- W4280537707 creator A5052115473 @default.
- W4280537707 creator A5054739437 @default.
- W4280537707 creator A5058488684 @default.
- W4280537707 creator A5078441367 @default.
- W4280537707 creator A5079638009 @default.
- W4280537707 creator A5090822716 @default.
- W4280537707 date "2022-04-21" @default.
- W4280537707 modified "2023-10-17" @default.
- W4280537707 title "Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment" @default.
- W4280537707 cites W1538704337 @default.
- W4280537707 cites W1780168192 @default.
- W4280537707 cites W1913165295 @default.
- W4280537707 cites W1965659086 @default.
- W4280537707 cites W1966438177 @default.
- W4280537707 cites W1969604041 @default.
- W4280537707 cites W1973953312 @default.
- W4280537707 cites W1976674183 @default.
- W4280537707 cites W1977072597 @default.
- W4280537707 cites W1978995286 @default.
- W4280537707 cites W1979983077 @default.
- W4280537707 cites W1988136757 @default.
- W4280537707 cites W1988359000 @default.
- W4280537707 cites W1990823750 @default.
- W4280537707 cites W1994713846 @default.
- W4280537707 cites W1995465307 @default.
- W4280537707 cites W2004173569 @default.
- W4280537707 cites W2005066460 @default.
- W4280537707 cites W2012479775 @default.
- W4280537707 cites W2014665497 @default.
- W4280537707 cites W2021476498 @default.
- W4280537707 cites W2024038437 @default.
- W4280537707 cites W2034131386 @default.
- W4280537707 cites W2035350056 @default.
- W4280537707 cites W2035640123 @default.
- W4280537707 cites W2037269009 @default.
- W4280537707 cites W2041491602 @default.
- W4280537707 cites W2046692960 @default.
- W4280537707 cites W2051295089 @default.
- W4280537707 cites W2053920789 @default.
- W4280537707 cites W2058509094 @default.
- W4280537707 cites W2062564926 @default.
- W4280537707 cites W2066306320 @default.
- W4280537707 cites W2066767531 @default.
- W4280537707 cites W2069282848 @default.
- W4280537707 cites W2071059761 @default.
- W4280537707 cites W2077090690 @default.
- W4280537707 cites W2078290093 @default.
- W4280537707 cites W2083005545 @default.
- W4280537707 cites W2083308412 @default.
- W4280537707 cites W2087758686 @default.
- W4280537707 cites W2095005430 @default.
- W4280537707 cites W2097499743 @default.
- W4280537707 cites W2111195206 @default.
- W4280537707 cites W2112891180 @default.
- W4280537707 cites W2132233425 @default.
- W4280537707 cites W2137137814 @default.
- W4280537707 cites W2145661073 @default.
- W4280537707 cites W2152369499 @default.
- W4280537707 cites W2170098987 @default.
- W4280537707 cites W2214287159 @default.
- W4280537707 cites W2235216797 @default.
- W4280537707 cites W2333291910 @default.
- W4280537707 cites W2588997868 @default.
- W4280537707 cites W2621316425 @default.
- W4280537707 cites W2736269864 @default.
- W4280537707 cites W2769709841 @default.
- W4280537707 cites W2791767507 @default.
- W4280537707 cites W2805173446 @default.
- W4280537707 cites W2888924355 @default.
- W4280537707 cites W2954359923 @default.
- W4280537707 cites W3004467451 @default.
- W4280537707 cites W3006646711 @default.
- W4280537707 cites W3012686914 @default.
- W4280537707 cites W3013463427 @default.
- W4280537707 cites W3016364957 @default.
- W4280537707 cites W3018209399 @default.
- W4280537707 cites W3093290846 @default.
- W4280537707 cites W3100115401 @default.
- W4280537707 cites W3122333407 @default.
- W4280537707 cites W3133440308 @default.
- W4280537707 cites W3135342605 @default.
- W4280537707 cites W3193241472 @default.
- W4280537707 cites W4211210212 @default.
- W4280537707 cites W4230557508 @default.
- W4280537707 cites W4244665723 @default.
- W4280537707 cites W4256080103 @default.
- W4280537707 doi "https://doi.org/10.1080/10837450.2022.2080221" @default.
- W4280537707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35587564" @default.
- W4280537707 hasPublicationYear "2022" @default.
- W4280537707 type Work @default.