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- W4280540827 abstract "Genipin is a protein cross-linking agent extracted from Gardenia (Gardenia jasminoides Ellis) fruits. This fruit has conventionally been used as a Chinese herbal medicine for the treatment of inflammation and jaundice and as an edible colorant in oriental countries. Uncoupling protein (UCP)-2 is a member of the family of uncoupling proteins, which are anion transporters positioned in the mitochondrial inner membrane. Genipin has been shown to have hepatoprotective activity, acting as an effective antioxidant and inhibitor of mitochondrial UCP2, and is also reported to exert significant anticancer effects. In this review, the author presents the latest progress of genipin as an anticancer agent and concisely describes its various mechanisms of action. In brief, genipin inhibits UCP2 to attenuate generation of reactive oxygen species (ROS), leading to ROS/c-Jun N-terminal kinase-dependent apoptosis of cancer cells. Genipin also increases the tissue inhibitors of matrix metalloproteases (MMP)-2, a kind of tumor promoter in a variety of cancers, as well as induces caspase-dependent apoptosis in in vitro and in vivo models. These findings suggest that genipin can serve as a promising novel antitumor agent that could be applicable for chemotherapy and/or chemoprevention for cancers." @default.
- W4280540827 created "2022-05-22" @default.
- W4280540827 creator A5033980148 @default.
- W4280540827 date "2022-05-18" @default.
- W4280540827 modified "2023-10-17" @default.
- W4280540827 title "Genipin, an Inhibitor of UCP2 as a Promising New Anticancer Agent: A Review of the Literature" @default.
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- W4280540827 doi "https://doi.org/10.3390/ijms23105637" @default.
- W4280540827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35628447" @default.
- W4280540827 hasPublicationYear "2022" @default.
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