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- W4280543210 abstract "Abstract A novel function for L1 cell adhesion molecule and its interaction with Ankyrin, an actin-spectrin adaptor protein, was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex. In an L1-null mouse mutant increased spine density was observed on apical but not basal dendrites of pyramidal neurons in diverse cortical areas (prefrontal cortex layer 2/3, motor cortex layer 5, visual cortex layer 4).The Ankyrin binding motif (FIGQY) in L1’s cytoplasmic domain was critical for spine formation, as demonstrated by increased spine density in the prefrontal cortex of a mouse mutant (L1YH) harboring a tyrosine to histidine mutation in this motif, which disrupts L1-Ankyrin association. This mutation is a known variant in the human L1 syndrome. In both mutants mature mushroom spines rather than immature spines were predominant. L1 was detected in spines and dendrites of wild-type prefrontal cortical neurons by immmunostaining. L1 coimmunoprecipitated with Ankyrin B (220 kDa) from cortical lysates of wild-type but not L1YH mice. Spine pruning assays in cortical neuron cultures from wild-type and L1YH mutant mice showed that the L1-Ankyrin interaction mediated spine retraction in response to the class 3 Semaphorins, Sema3F and to a lesser extent Sema3B. These ligands also induce spine pruning through other L1 family adhesion molecules, NrCAM and Close Homolog of L1 (CHL1), respectively. This study provides insight into the molecular mechanism of spine regulation and underscore the potential for this adhesion molecule to regulate cognitive and other L1-related functions that are abnormal in the L1 syndrome." @default.
- W4280543210 created "2022-05-22" @default.
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- W4280543210 date "2022-05-16" @default.
- W4280543210 modified "2023-10-15" @default.
- W4280543210 title "The L1 Cell Adhesion Molecule Constrains Dendritic Spine Density through Ankyrin Binding in Pyramidal Neurons of the Mouse Cerebral Cortex" @default.
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- W4280543210 doi "https://doi.org/10.1101/2022.05.16.492130" @default.
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