Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280544218> ?p ?o ?g. }
- W4280544218 abstract "Abstract Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors contribute to treatment failure and an unfavorable prognosis. Personalized tumor models faithfully capturing the tumor heterogeneity of individual patients are urgently needed for precision medicine. Advances in stem cell culture have given rise to powerful organoid technology for the generation of in vitro three-dimensional tissues that have been shown to more accurately recapitulate the structures, specific functions, molecular characteristics, genomic alterations, expression profiles, and tumor microenvironment of primary tumors. Tumoroids in vitro serve as an important component of the pipeline for the discovery of potential therapeutic targets and the identification of novel compounds. In this review, we will summarize recent advances in tumoroid cultures as an excellent tool for accurate cancer modeling. Additionally, vascularization and immune microenvironment modeling based on organoid technology will also be described. Furthermore, we will summarize the great potential of tumor organoids in predicting the therapeutic response, investigating resistance-related mechanisms, optimizing treatment strategies, and exploring potential therapies. In addition, the bottlenecks and challenges of current tumoroids will also be discussed in this review." @default.
- W4280544218 created "2022-05-22" @default.
- W4280544218 creator A5010134199 @default.
- W4280544218 creator A5044031959 @default.
- W4280544218 creator A5049880729 @default.
- W4280544218 creator A5087093116 @default.
- W4280544218 date "2022-05-12" @default.
- W4280544218 modified "2023-10-18" @default.
- W4280544218 title "Tumor organoids: applications in cancer modeling and potentials in precision medicine" @default.
- W4280544218 cites W1182461782 @default.
- W4280544218 cites W1792291729 @default.
- W4280544218 cites W1970910239 @default.
- W4280544218 cites W1971386572 @default.
- W4280544218 cites W1981421409 @default.
- W4280544218 cites W2010916968 @default.
- W4280544218 cites W2034428193 @default.
- W4280544218 cites W2047918294 @default.
- W4280544218 cites W2052700237 @default.
- W4280544218 cites W2059586354 @default.
- W4280544218 cites W2079239846 @default.
- W4280544218 cites W2097121410 @default.
- W4280544218 cites W2124358769 @default.
- W4280544218 cites W2130364039 @default.
- W4280544218 cites W2134433047 @default.
- W4280544218 cites W2146177965 @default.
- W4280544218 cites W2162181903 @default.
- W4280544218 cites W2255555283 @default.
- W4280544218 cites W2296338206 @default.
- W4280544218 cites W2510834891 @default.
- W4280544218 cites W2574695762 @default.
- W4280544218 cites W2601380465 @default.
- W4280544218 cites W2603665089 @default.
- W4280544218 cites W2617118245 @default.
- W4280544218 cites W2619944463 @default.
- W4280544218 cites W2740653964 @default.
- W4280544218 cites W2742209106 @default.
- W4280544218 cites W2751733606 @default.
- W4280544218 cites W2757236955 @default.
- W4280544218 cites W2767274043 @default.
- W4280544218 cites W2769647132 @default.
- W4280544218 cites W2771057425 @default.
- W4280544218 cites W2773981699 @default.
- W4280544218 cites W2782830341 @default.
- W4280544218 cites W2787956080 @default.
- W4280544218 cites W2788735115 @default.
- W4280544218 cites W2789773980 @default.
- W4280544218 cites W2790797622 @default.
- W4280544218 cites W2795248085 @default.
- W4280544218 cites W2795679584 @default.
- W4280544218 cites W2799444748 @default.
- W4280544218 cites W2799791049 @default.
- W4280544218 cites W2801859531 @default.
- W4280544218 cites W2802638385 @default.
- W4280544218 cites W2802943395 @default.
- W4280544218 cites W2804689115 @default.
- W4280544218 cites W2808350668 @default.
- W4280544218 cites W2870910716 @default.
- W4280544218 cites W2885650843 @default.
- W4280544218 cites W2887409499 @default.
- W4280544218 cites W2889646458 @default.
- W4280544218 cites W2890662076 @default.
- W4280544218 cites W2890912772 @default.
- W4280544218 cites W2891846853 @default.
- W4280544218 cites W2892107476 @default.
- W4280544218 cites W2892244711 @default.
- W4280544218 cites W2896450660 @default.
- W4280544218 cites W2900098081 @default.
- W4280544218 cites W2902731954 @default.
- W4280544218 cites W2905447079 @default.
- W4280544218 cites W2907907709 @default.
- W4280544218 cites W2911605935 @default.
- W4280544218 cites W2912813083 @default.
- W4280544218 cites W2913214687 @default.
- W4280544218 cites W2913928134 @default.
- W4280544218 cites W2917503791 @default.
- W4280544218 cites W2917970591 @default.
- W4280544218 cites W2921882381 @default.
- W4280544218 cites W2923099616 @default.
- W4280544218 cites W2939036329 @default.
- W4280544218 cites W2946001968 @default.
- W4280544218 cites W2946448736 @default.
- W4280544218 cites W2947606319 @default.
- W4280544218 cites W2951426376 @default.
- W4280544218 cites W2958872567 @default.
- W4280544218 cites W2963036225 @default.
- W4280544218 cites W2966555775 @default.
- W4280544218 cites W2966573848 @default.
- W4280544218 cites W2971872568 @default.
- W4280544218 cites W2977860139 @default.
- W4280544218 cites W2978373708 @default.
- W4280544218 cites W2979121189 @default.
- W4280544218 cites W2979291688 @default.
- W4280544218 cites W2979586447 @default.
- W4280544218 cites W2982368706 @default.
- W4280544218 cites W2987385271 @default.
- W4280544218 cites W2987428409 @default.
- W4280544218 cites W2991319487 @default.
- W4280544218 cites W2991669855 @default.
- W4280544218 cites W2994559322 @default.
- W4280544218 cites W2995460694 @default.