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- W4280544277 endingPage "2051" @default.
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- W4280544277 abstract "Direct enzymatic hydroxylation of prochiral alkylnitriles represents a green and efficient synthesis of chiral β-hydroxy nitriles, but reported examples are very inefficient and limited. Here we describe the development of an evolved P450pyr monooxygenase for enantioselective benzylic hydroxylation of alkylnitriles. By the use of an engineered P450pyr-D5M3 mutant, a variety of pharmaceutically relevant chiral aryl-substituted β-hydroxy nitriles were prepared from prochiral 3-arylpropanenitriles in moderate yields with excellent enantioselectivities." @default.
- W4280544277 created "2022-05-22" @default.
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- W4280544277 date "2022-05-10" @default.
- W4280544277 modified "2023-10-15" @default.
- W4280544277 title "Highly Enantioselective Hydroxylation of 3-Arylpropanenitriles to Access Chiral β-Hydroxy Nitriles by Engineering of P450pyr Monooxygenase" @default.
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- W4280544277 doi "https://doi.org/10.1021/acs.oprd.1c00444" @default.
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