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- W4280548695 abstract "Abstract Protein‐ O ‐glycosylation has been shown to be essential for many biological processes. However, determining the exact relationship between O ‐glycan structures and their biological activity remains challenging. Here we report that, unlike azides, sydnones can be incorporated as an aglycon into core 1 O ‐glycans early‐on in their synthesis since it is compatible with carbohydrate chemistry and enzymatic glycosylations, allowing us to generate a small library of sydnone‐containing core 1 O ‐glycans by chemoenzymatic synthesis. The sydnone‐aglycon was then employed for the facile preparation of an O ‐glycan array, via bioorthogonal strain‐promoted sydnone‐alkyne cycloaddition click reaction, and in turn was utilized for the high‐throughput screening of O‐ glycan‐lectin interactions. This sydnone‐aglycon, particularly adapted for O ‐glycomics, is a valuable chemical tool that complements the limited technologies available for investigating O ‐glycan structure‐activity relationships." @default.
- W4280548695 created "2022-05-22" @default.
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- W4280548695 date "2022-05-12" @default.
- W4280548695 modified "2023-09-30" @default.
- W4280548695 title "A Clickable Bioorthogonal Sydnone‐Aglycone for the Facile Preparation of a Core 1 <i>O</i>‐Glycan‐Array" @default.
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- W4280548695 doi "https://doi.org/10.1002/ejoc.202200271" @default.
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