Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280548793> ?p ?o ?g. }
- W4280548793 endingPage "112555" @default.
- W4280548793 startingPage "112555" @default.
- W4280548793 abstract "Heparin, the most widely used anticoagulant drug in the world today, suffers from the risk of overdose and a short serum half-life, limiting its clinical applications. Concerning the controlled, sustained, and targeted release of heparin, a delivery system was fabricated in this research using the layered composites of Fe3O4 magnetic particles and pH-sensitive metal-organic framework, Fe3O4@ZIF-8. The composite demonstrated a high loading capacity for the heparin, 66.8 mg/g. The composite had a saturation magnetization of 1.5 emu/g and thus owned a magnetic targeting function, i.e. drug can be centered at a certain point using an external magnetic field. The anticoagulant activity was assessed by monitoring their activated partial thromboplastin time. The results showed that the pH-responsive and sustained release of the heparin reduced the systemic adverse effects associated with high concentrations. Moreover, control over the dose exhibited excellent anticoagulant features with fewer side effects." @default.
- W4280548793 created "2022-05-22" @default.
- W4280548793 creator A5041545340 @default.
- W4280548793 creator A5050803462 @default.
- W4280548793 creator A5054186030 @default.
- W4280548793 creator A5057935426 @default.
- W4280548793 creator A5064847781 @default.
- W4280548793 creator A5075141324 @default.
- W4280548793 date "2022-08-01" @default.
- W4280548793 modified "2023-10-18" @default.
- W4280548793 title "Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin" @default.
- W4280548793 cites W1908961838 @default.
- W4280548793 cites W1971264289 @default.
- W4280548793 cites W2013537866 @default.
- W4280548793 cites W2013933993 @default.
- W4280548793 cites W2017139362 @default.
- W4280548793 cites W2044490764 @default.
- W4280548793 cites W2053179045 @default.
- W4280548793 cites W2058559717 @default.
- W4280548793 cites W2071086809 @default.
- W4280548793 cites W2115313702 @default.
- W4280548793 cites W2121886286 @default.
- W4280548793 cites W2470111997 @default.
- W4280548793 cites W2519603145 @default.
- W4280548793 cites W2748619010 @default.
- W4280548793 cites W2788884368 @default.
- W4280548793 cites W2810524025 @default.
- W4280548793 cites W2886864981 @default.
- W4280548793 cites W2887799451 @default.
- W4280548793 cites W2945954305 @default.
- W4280548793 cites W2998965924 @default.
- W4280548793 cites W3007768281 @default.
- W4280548793 cites W3008213824 @default.
- W4280548793 cites W3009132340 @default.
- W4280548793 cites W3017165857 @default.
- W4280548793 cites W3130991347 @default.
- W4280548793 cites W3134997801 @default.
- W4280548793 cites W3162189685 @default.
- W4280548793 cites W3214274006 @default.
- W4280548793 cites W4238430188 @default.
- W4280548793 doi "https://doi.org/10.1016/j.colsurfb.2022.112555" @default.
- W4280548793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35598509" @default.
- W4280548793 hasPublicationYear "2022" @default.
- W4280548793 type Work @default.
- W4280548793 citedByCount "4" @default.
- W4280548793 countsByYear W42805487932022 @default.
- W4280548793 countsByYear W42805487932023 @default.
- W4280548793 crossrefType "journal-article" @default.
- W4280548793 hasAuthorship W4280548793A5041545340 @default.
- W4280548793 hasAuthorship W4280548793A5050803462 @default.
- W4280548793 hasAuthorship W4280548793A5054186030 @default.
- W4280548793 hasAuthorship W4280548793A5057935426 @default.
- W4280548793 hasAuthorship W4280548793A5064847781 @default.
- W4280548793 hasAuthorship W4280548793A5075141324 @default.
- W4280548793 hasConcept C104779481 @default.
- W4280548793 hasConcept C126322002 @default.
- W4280548793 hasConcept C127413603 @default.
- W4280548793 hasConcept C136229726 @default.
- W4280548793 hasConcept C136525101 @default.
- W4280548793 hasConcept C141071460 @default.
- W4280548793 hasConcept C142724271 @default.
- W4280548793 hasConcept C159985019 @default.
- W4280548793 hasConcept C163588942 @default.
- W4280548793 hasConcept C171250308 @default.
- W4280548793 hasConcept C185592680 @default.
- W4280548793 hasConcept C188198153 @default.
- W4280548793 hasConcept C192562407 @default.
- W4280548793 hasConcept C204787440 @default.
- W4280548793 hasConcept C2777557582 @default.
- W4280548793 hasConcept C2778205648 @default.
- W4280548793 hasConcept C2778261982 @default.
- W4280548793 hasConcept C2778382381 @default.
- W4280548793 hasConcept C55493867 @default.
- W4280548793 hasConcept C71924100 @default.
- W4280548793 hasConcept C78519656 @default.
- W4280548793 hasConceptScore W4280548793C104779481 @default.
- W4280548793 hasConceptScore W4280548793C126322002 @default.
- W4280548793 hasConceptScore W4280548793C127413603 @default.
- W4280548793 hasConceptScore W4280548793C136229726 @default.
- W4280548793 hasConceptScore W4280548793C136525101 @default.
- W4280548793 hasConceptScore W4280548793C141071460 @default.
- W4280548793 hasConceptScore W4280548793C142724271 @default.
- W4280548793 hasConceptScore W4280548793C159985019 @default.
- W4280548793 hasConceptScore W4280548793C163588942 @default.
- W4280548793 hasConceptScore W4280548793C171250308 @default.
- W4280548793 hasConceptScore W4280548793C185592680 @default.
- W4280548793 hasConceptScore W4280548793C188198153 @default.
- W4280548793 hasConceptScore W4280548793C192562407 @default.
- W4280548793 hasConceptScore W4280548793C204787440 @default.
- W4280548793 hasConceptScore W4280548793C2777557582 @default.
- W4280548793 hasConceptScore W4280548793C2778205648 @default.
- W4280548793 hasConceptScore W4280548793C2778261982 @default.
- W4280548793 hasConceptScore W4280548793C2778382381 @default.
- W4280548793 hasConceptScore W4280548793C55493867 @default.
- W4280548793 hasConceptScore W4280548793C71924100 @default.
- W4280548793 hasConceptScore W4280548793C78519656 @default.
- W4280548793 hasLocation W42805487931 @default.
- W4280548793 hasLocation W42805487932 @default.