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- W4280549198 abstract "The murine serous cavities contain a rare and enigmatic population of short-lived F4/80lo MHCII+ macrophages but what regulates their development, survival, and fate is unclear. Here, we show that mature F4/80lo MHCII+ peritoneal macrophages arise after birth, but that this occurs largely independently of colonization by microbiota. Rather, microbiota specifically regulate development of a subpopulation of CD11c+ cells that express the immunoregulatory cytokine RELM-α, are reliant on the transcription factor EGR2, and develop independently of the growth factor CSF1. Furthermore, we demonstrate that intrinsic expression of RELM-α, a signature marker shared by CD11c+ and CD11c- F4/80lo MHCII+ cavity macrophages, regulates survival and differentiation of these cells in the peritoneal cavity in a sex-specific manner. Thus, we identify a previously unappreciated diversity in serous cavity F4/80lo MHCII+ macrophages that is regulated by microbiota, and describe a novel sex and site-specific function for RELM-α in regulating macrophage endurance that reveals the unique survival challenge presented to monocyte-derived macrophages by the female peritoneal environment." @default.
- W4280549198 created "2022-05-22" @default.
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- W4280549198 date "2022-05-24" @default.
- W4280549198 modified "2023-09-30" @default.
- W4280549198 title "CD11c identifies microbiota and EGR2‐dependent MHCII<sup>+</sup> serous cavity macrophages with sexually dimorphic fate in mice" @default.
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- W4280549198 doi "https://doi.org/10.1002/eji.202149756" @default.
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