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- W4280550147 endingPage "102286" @default.
- W4280550147 startingPage "102286" @default.
- W4280550147 abstract "There is a large unmet need for improved treatment for temporal lobe epilepsy (TLE); circuit-specific manipulation that disrupts the initiation and propagation of seizures is promising in this regard. The midline thalamus, including the mediodorsal nucleus (MD) is a critical distributor of seizure activity, but its afferent and efferent pathways that mediate seizure activity are unknown. Here, we used chemogenetics to silence input and output projections of the MD to discrete regions of the frontal cortex in the kindling model of TLE in rats. Chemogenetic inhibition of the projection from the amygdala to the MD abolished seizures, an effect that was replicated using optogenetic inhibition. Chemogenetic inhibition of projections from the MD to the prelimbic cortex likewise abolished seizures. By contrast, inhibition of projections from the MD to other frontal regions produced partial (orbitofrontal cortex, infralimbic cortex) or no (cingulate, insular cortex) attenuation of behavioral or electrographic seizure activity. These results highlight the particular importance of projections from MD to prelimbic cortex in the propagation of amygdala-kindled seizures." @default.
- W4280550147 created "2022-05-22" @default.
- W4280550147 creator A5036232159 @default.
- W4280550147 creator A5043242939 @default.
- W4280550147 creator A5063472861 @default.
- W4280550147 date "2022-07-01" @default.
- W4280550147 modified "2023-10-15" @default.
- W4280550147 title "Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures" @default.
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