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- W4280551330 endingPage "220" @default.
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- W4280551330 abstract "Abstract: Endothelial dysfunction is a crucial physiopathological mechanism for cardiovascular diseases that results from the harmful impact of metabolic disorders. Irisin, a recently discovered adipomyokine, has been shown to exert beneficial metabolic effects by increasing energy consumption, improving insulin sensitivity, and reducing the proinflammatory milieu. Multiple preclinical models have assessed irisin's possible role in the development of endothelial dysfunction, displaying that treatment with exogenous irisin can decrease the production of oxidative stress mediators by up-regulating Akt/mTOR/Nrf2 pathway, promote endothelial-dependent vasodilatation through the activation of AMPK-PI3K-AkteNOS pathway, and increase the endothelial cell viability by activation of ERK proliferation pathway and downregulation of Bad/Bax/Caspase 3 pro-apoptotic pathway. However, there is scarce evidence of these mechanisms in clinical studies, and available results are controversial. Some have shown negative correlations of irisin levels with the burden of coronary atherosclerosis and leukocyte adhesion molecules' expression. Others have demonstrated associations between irisin levels and increased atherosclerosis risk and higher carotid intima-media thickness. Since the role of irisin in endothelial damage remains unclear, in this review, we compare, contrast, and integrate the current knowledge from preclinical and clinical studies to elucidate the potential preventive role and the underlying mechanisms and pathways of irisin in endothelial dysfunction. This review also comprises original figures to illustrate these mechanisms." @default.
- W4280551330 created "2022-05-22" @default.
- W4280551330 creator A5028653431 @default.
- W4280551330 creator A5033086198 @default.
- W4280551330 creator A5044141839 @default.
- W4280551330 date "2022-03-01" @default.
- W4280551330 modified "2023-10-18" @default.
- W4280551330 title "Current Insights on the Role of Irisin in Endothelial Dysfunction" @default.
- W4280551330 cites W1481177852 @default.
- W4280551330 cites W1778603900 @default.
- W4280551330 cites W1821824803 @default.
- W4280551330 cites W1851653849 @default.
- W4280551330 cites W1886130798 @default.
- W4280551330 cites W1920206190 @default.
- W4280551330 cites W1931609017 @default.
- W4280551330 cites W1962787573 @default.
- W4280551330 cites W1969409088 @default.
- W4280551330 cites W1970322195 @default.
- W4280551330 cites W1978546032 @default.
- W4280551330 cites W1981044204 @default.
- W4280551330 cites W1983986440 @default.
- W4280551330 cites W1988173340 @default.
- W4280551330 cites W1992592020 @default.
- W4280551330 cites W1997023449 @default.
- W4280551330 cites W2000249408 @default.
- W4280551330 cites W2002717704 @default.
- W4280551330 cites W2003356783 @default.
- W4280551330 cites W2005796050 @default.
- W4280551330 cites W2006519499 @default.
- W4280551330 cites W2010220940 @default.
- W4280551330 cites W2011659325 @default.
- W4280551330 cites W2013863446 @default.
- W4280551330 cites W2026581189 @default.
- W4280551330 cites W2035769097 @default.
- W4280551330 cites W2040337588 @default.
- W4280551330 cites W2041427283 @default.
- W4280551330 cites W2043934279 @default.
- W4280551330 cites W2046500896 @default.
- W4280551330 cites W2050548878 @default.
- W4280551330 cites W2051645126 @default.
- W4280551330 cites W2066454958 @default.
- W4280551330 cites W2068516046 @default.
- W4280551330 cites W2084238243 @default.
- W4280551330 cites W2085397620 @default.
- W4280551330 cites W2088940658 @default.
- W4280551330 cites W2090974810 @default.
- W4280551330 cites W2096033670 @default.
- W4280551330 cites W2097796010 @default.
- W4280551330 cites W2111778724 @default.
- W4280551330 cites W2119545067 @default.
- W4280551330 cites W2125507553 @default.
- W4280551330 cites W2139308223 @default.
- W4280551330 cites W2144366742 @default.
- W4280551330 cites W2147089512 @default.
- W4280551330 cites W2150975834 @default.
- W4280551330 cites W2152809661 @default.
- W4280551330 cites W2154298792 @default.
- W4280551330 cites W2154758223 @default.
- W4280551330 cites W2155514454 @default.
- W4280551330 cites W2166830703 @default.
- W4280551330 cites W2167248595 @default.
- W4280551330 cites W2171944308 @default.
- W4280551330 cites W2172004618 @default.
- W4280551330 cites W2174193152 @default.
- W4280551330 cites W2182948109 @default.
- W4280551330 cites W2193994735 @default.
- W4280551330 cites W2302744463 @default.
- W4280551330 cites W2319333257 @default.
- W4280551330 cites W2327030088 @default.
- W4280551330 cites W2334240341 @default.
- W4280551330 cites W2350097523 @default.
- W4280551330 cites W2433533478 @default.
- W4280551330 cites W2465763867 @default.
- W4280551330 cites W2475189633 @default.
- W4280551330 cites W2520515896 @default.
- W4280551330 cites W2524572775 @default.
- W4280551330 cites W2543544500 @default.
- W4280551330 cites W2547194338 @default.
- W4280551330 cites W2589560596 @default.
- W4280551330 cites W2598054368 @default.
- W4280551330 cites W2600882296 @default.
- W4280551330 cites W2606994753 @default.
- W4280551330 cites W2611570557 @default.
- W4280551330 cites W2614578122 @default.
- W4280551330 cites W2624598165 @default.
- W4280551330 cites W2743110890 @default.
- W4280551330 cites W2749435773 @default.
- W4280551330 cites W2750880061 @default.
- W4280551330 cites W2765997892 @default.
- W4280551330 cites W2766088187 @default.
- W4280551330 cites W2767324860 @default.
- W4280551330 cites W2790943882 @default.
- W4280551330 cites W2790949929 @default.
- W4280551330 cites W2791453970 @default.
- W4280551330 cites W2791661083 @default.
- W4280551330 cites W2792585611 @default.
- W4280551330 cites W2801707319 @default.
- W4280551330 cites W2804248423 @default.