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• W4280552372 startingPage "589" @default.
• W4280552372 abstract "Transauricular vagal nerve stimulation (taVNS) at 40 Hz attenuates hippocampal amyloid load in 6-month-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice, but it is unclear whether 40-Hz taVNS can improve cognition in these mice. Moreover, the underlying mechanisms are still unclear.6-month-old C57BL/6 (wild type [WT]) and APP/PS1 mice were subjected to 40-Hz taVNS. Novel Object Recognition and the Morris Water Maze were used to evaluate cognition. Hippocampal amyloid-β (Aβ)1-40, Aβ1-42, pro-interleukin (IL)-1β, and pro-IL-18 were measured using enzyme-linked immunosorbent assays. Hippocampal Aβ42, purinergic 2X7 receptor (P2X7R), nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3), Caspase-1, IL-1β, and IL-18 expression were evaluated by western blotting. Histologic assessments including immunofluorescence, immunohistochemistry, Nissl staining, and Congo red staining were used to assess microglial phagocytosis, neuroprotective effects, and Aβ plaque load.40-Hz taVNS improved spatial memory and learning in 6-month-old APP/PS1 mice but did not affect recognition memory. There were no effects on the cognitive behaviors of 6-month-old WT mice. taVNS at 40 Hz modulated microglia; significantly decreased levels of Aβ1-40, Aβ1-42, pro-IL-1β, and pro-IL-18; inhibited Aβ42, P2X7R, NLRP3, Caspase-1, IL-1β, and IL-18 expression; reduced Aβ deposits; and had neuroprotective effects in the hippocampus of 6-month-old APP/PS1 mice. These changes were not observed in 6-month-old WT mice.Our results show that 40-Hz taVNS inhibits the hippocampal P2X7R/NLRP3/Caspase-1 signaling and improves spatial learning and memory in 6-month-old APP/PS1 mice." @default.
• W4280552372 created "2022-05-22" @default.
• W4280552372 creator A5013121971 @default.
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• W4280552372 date "2023-04-01" @default.
• W4280552372 modified "2023-10-06" @default.
• W4280552372 title "Transauricular Vagal Nerve Stimulation at 40 Hz Inhibits Hippocampal P2X7R/NLRP3/Caspase-1 Signaling and Improves Spatial Learning and Memory in 6-Month-Old APP/PS1 Mice" @default.
• W4280552372 cites W1561041814 @default.
• W4280552372 cites W1571910978 @default.
• W4280552372 cites W1577331826 @default.
• W4280552372 cites W1634720708 @default.
• W4280552372 cites W1811472601 @default.
• W4280552372 cites W1947069133 @default.
• W4280552372 cites W1963721982 @default.
• W4280552372 cites W1967535998 @default.
• W4280552372 cites W1980606251 @default.
• W4280552372 cites W1986611577 @default.
• W4280552372 cites W1991634503 @default.
• W4280552372 cites W1993976394 @default.
• W4280552372 cites W2014704049 @default.
• W4280552372 cites W2016520377 @default.
• W4280552372 cites W2016811754 @default.
• W4280552372 cites W2020824841 @default.
• W4280552372 cites W2024689361 @default.
• W4280552372 cites W2027502669 @default.
• W4280552372 cites W2036420702 @default.
• W4280552372 cites W2040023204 @default.
• W4280552372 cites W2040560106 @default.
• W4280552372 cites W2044210137 @default.
• W4280552372 cites W2047640891 @default.
• W4280552372 cites W2057990081 @default.
• W4280552372 cites W2064874359 @default.
• W4280552372 cites W2064909736 @default.
• W4280552372 cites W2070448139 @default.
• W4280552372 cites W2076027445 @default.
• W4280552372 cites W2080756849 @default.
• W4280552372 cites W2084652820 @default.
• W4280552372 cites W2087243986 @default.
• W4280552372 cites W2089503694 @default.
• W4280552372 cites W2090859543 @default.
• W4280552372 cites W2091319478 @default.
• W4280552372 cites W2092817697 @default.
• W4280552372 cites W2099751992 @default.
• W4280552372 cites W2101301575 @default.
• W4280552372 cites W2111191371 @default.
• W4280552372 cites W2114769428 @default.
• W4280552372 cites W2115017507 @default.
• W4280552372 cites W2119098586 @default.
• W4280552372 cites W2130065525 @default.
• W4280552372 cites W2134735862 @default.
• W4280552372 cites W2142823391 @default.
• W4280552372 cites W2142943752 @default.
• W4280552372 cites W2171542393 @default.
• W4280552372 cites W2411572788 @default.
• W4280552372 cites W2560234750 @default.
• W4280552372 cites W2593488234 @default.
• W4280552372 cites W2737555531 @default.
• W4280552372 cites W2776183201 @default.
• W4280552372 cites W2776458751 @default.
• W4280552372 cites W2791444686 @default.
• W4280552372 cites W2808809552 @default.
• W4280552372 cites W2891569200 @default.
• W4280552372 cites W2897533172 @default.
• W4280552372 cites W2900726683 @default.
• W4280552372 cites W2922175568 @default.
• W4280552372 cites W2937162889 @default.
• W4280552372 cites W2944762438 @default.
• W4280552372 cites W2959846326 @default.
• W4280552372 cites W2964477120 @default.
• W4280552372 cites W2984141991 @default.
• W4280552372 cites W2995828272 @default.
• W4280552372 cites W2998021060 @default.
• W4280552372 cites W3006198998 @default.
• W4280552372 cites W3025526179 @default.
• W4280552372 cites W3033171974 @default.
• W4280552372 cites W3034089712 @default.
• W4280552372 cites W3042480678 @default.
• W4280552372 cites W3087789132 @default.
• W4280552372 cites W3093490267 @default.
• W4280552372 cites W3100761942 @default.
• W4280552372 cites W3111509171 @default.
• W4280552372 cites W3116829887 @default.
• W4280552372 cites W3126426752 @default.
• W4280552372 cites W3179601776 @default.
• W4280552372 cites W3180978278 @default.
• W4280552372 cites W3194048913 @default.
• W4280552372 cites W3215526639 @default.
• W4280552372 cites W4200002228 @default.
• W4280552372 cites W4200409452 @default.
• W4280552372 cites W4292167789 @default.
• W4280552372 doi "https://doi.org/10.1016/j.neurom.2022.03.011" @default.

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