FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280553679> ?p ?o ?g. }

• W4280553679 abstract "HIV-1 drug resistance genotyping is critical to the monitoring of antiretroviral treatment. Data on HIV-1 genotyping success rates of different laboratory specimen types from multiple sources is still scarce.In this cross-sectional study, we determined the laboratory genotyping success rates (GSR) and assessed the correlates of genotyping failure of 6837 unpaired dried blood spot (DBS) and plasma specimens. Specimens from multiple studies in a resource-constrained setting were analysed in our laboratory between 2016 and 2019.We noted an overall GSR of 65.7% and specific overall GSR for DBS and plasma of 49.8% and 85.9% respectively. The correlates of genotyping failure were viral load (VL) < 10,000 copies/mL (aOR 0.3 95% CI: 0.24-0.38; p < 0.0001), lack of viral load testing prior to genotyping (OR 0.85 95% CI: 0.77-0.94; p = 0.002), use of DBS specimens (aOR 0.10 95% CI: 0.08-0.14; p < 0.0001) and specimens from routine clinical diagnosis (aOR 1.4 95% CI: 1.10-1.75; p = 0.005).We report rapidly decreasing HIV-1 genotyping success rates between 2016 and 2019 with increased use of DBS specimens for genotyping and note decreasing median viral loads over the years. We recommend improvement in DBS handling, pre-genotyping viral load testing to screen samples to enhance genotyping success and the development of more sensitive assays with well-designed primers to genotype specimens with low or undetectable viral load, especially in this era where virological suppression rates are rising due to increased antiretroviral therapy roll-out." @default.
• W4280553679 created "2022-05-22" @default.
• W4280553679 creator A5002865552 @default.
• W4280553679 creator A5008583435 @default.
• W4280553679 creator A5011024969 @default.
• W4280553679 creator A5027055634 @default.
• W4280553679 creator A5031115510 @default.
• W4280553679 creator A5049170891 @default.
• W4280553679 creator A5051302353 @default.
• W4280553679 creator A5052472077 @default.
• W4280553679 creator A5071331157 @default.
• W4280553679 creator A5086720951 @default.
• W4280553679 date "2022-05-17" @default.
• W4280553679 modified "2023-10-06" @default.
• W4280553679 title "HIV-1 drug resistance genotyping success rates and correlates of Dried-blood spots and plasma specimen genotyping failure in a resource-limited setting" @default.
• W4280553679 cites W107872265 @default.
• W4280553679 cites W1794134895 @default.
• W4280553679 cites W1969862288 @default.
• W4280553679 cites W1999651806 @default.
• W4280553679 cites W2001632118 @default.
• W4280553679 cites W2010046108 @default.
• W4280553679 cites W2014920569 @default.
• W4280553679 cites W2022496141 @default.
• W4280553679 cites W2031465040 @default.
• W4280553679 cites W2039143356 @default.
• W4280553679 cites W2048253923 @default.
• W4280553679 cites W2052555942 @default.
• W4280553679 cites W2052727694 @default.
• W4280553679 cites W2084710826 @default.
• W4280553679 cites W2097997920 @default.
• W4280553679 cites W2102232203 @default.
• W4280553679 cites W2111343480 @default.
• W4280553679 cites W2122429905 @default.
• W4280553679 cites W2126173545 @default.
• W4280553679 cites W2132367670 @default.
• W4280553679 cites W2133758885 @default.
• W4280553679 cites W2139266935 @default.
• W4280553679 cites W2141052558 @default.
• W4280553679 cites W2142639094 @default.
• W4280553679 cites W2154137485 @default.
• W4280553679 cites W2154164013 @default.
• W4280553679 cites W2163009984 @default.
• W4280553679 cites W2192486531 @default.
• W4280553679 cites W2206876875 @default.
• W4280553679 cites W2462213043 @default.
• W4280553679 cites W2559421547 @default.
• W4280553679 cites W2589862247 @default.
• W4280553679 cites W2604987899 @default.
• W4280553679 cites W2784199969 @default.
• W4280553679 cites W2888515292 @default.
• W4280553679 cites W2891179020 @default.
• W4280553679 cites W2900379981 @default.
• W4280553679 cites W2912792771 @default.
• W4280553679 cites W2927292733 @default.
• W4280553679 cites W2956144941 @default.
• W4280553679 cites W3005499408 @default.
• W4280553679 cites W3160039208 @default.
• W4280553679 cites W76024419 @default.
• W4280553679 cites W894122524 @default.
• W4280553679 doi "https://doi.org/10.1186/s12879-022-07453-9" @default.
• W4280553679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35581555" @default.
• W4280553679 hasPublicationYear "2022" @default.
• W4280553679 type Work @default.
• W4280553679 citedByCount "1" @default.
• W4280553679 countsByYear W42805536792023 @default.
• W4280553679 crossrefType "journal-article" @default.
• W4280553679 hasAuthorship W4280553679A5002865552 @default.
• W4280553679 hasAuthorship W4280553679A5008583435 @default.
• W4280553679 hasAuthorship W4280553679A5011024969 @default.
• W4280553679 hasAuthorship W4280553679A5027055634 @default.
• W4280553679 hasAuthorship W4280553679A5031115510 @default.
• W4280553679 hasAuthorship W4280553679A5049170891 @default.
• W4280553679 hasAuthorship W4280553679A5051302353 @default.
• W4280553679 hasAuthorship W4280553679A5052472077 @default.
• W4280553679 hasAuthorship W4280553679A5071331157 @default.
• W4280553679 hasAuthorship W4280553679A5086720951 @default.
• W4280553679 hasBestOaLocation W42805536791 @default.
• W4280553679 hasConcept C104317684 @default.
• W4280553679 hasConcept C114851261 @default.
• W4280553679 hasConcept C126322002 @default.
• W4280553679 hasConcept C135763542 @default.
• W4280553679 hasConcept C142462285 @default.
• W4280553679 hasConcept C159047783 @default.
• W4280553679 hasConcept C203014093 @default.
• W4280553679 hasConcept C2776597655 @default.
• W4280553679 hasConcept C3013748606 @default.
• W4280553679 hasConcept C31467283 @default.
• W4280553679 hasConcept C54355233 @default.
• W4280553679 hasConcept C71924100 @default.
• W4280553679 hasConcept C86803240 @default.
• W4280553679 hasConceptScore W4280553679C104317684 @default.
• W4280553679 hasConceptScore W4280553679C114851261 @default.
• W4280553679 hasConceptScore W4280553679C126322002 @default.
• W4280553679 hasConceptScore W4280553679C135763542 @default.
• W4280553679 hasConceptScore W4280553679C142462285 @default.
• W4280553679 hasConceptScore W4280553679C159047783 @default.
• W4280553679 hasConceptScore W4280553679C203014093 @default.
• W4280553679 hasConceptScore W4280553679C2776597655 @default.
• W4280553679 hasConceptScore W4280553679C3013748606 @default.
• W4280553679 hasConceptScore W4280553679C31467283 @default.

• next