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- W4280553695 abstract "Preclinical studies have shown that volatile anesthetics may have beneficial effects on injured lungs, and pilot clinical data support improved arterial oxygenation, attenuated inflammation, and decreased lung epithelial injury in patients with acute respiratory distress syndrome (ARDS) receiving inhaled sevoflurane compared to intravenous midazolam. Whether sevoflurane is effective in improving clinical outcomes among patients with ARDS is unknown, and the benefits and risks of inhaled sedation in ARDS require further evaluation. Here, we describe the SESAR (Sevoflurane for Sedation in ARDS) trial designed to address this question. SESAR is a two-arm, investigator-initiated, multicenter, prospective, randomized, stratified, parallel-group clinical trial with blinded outcome assessment designed to test the efficacy of sedation with sevoflurane compared to intravenous propofol in patients with moderate to severe ARDS. The primary outcome is the number of days alive and off the ventilator at 28 days, considering death as a competing event, and the key secondary outcome is 90 day survival. The planned enrollment is 700 adult participants at 37 French academic and non-academic centers. Safety and long-term outcomes will be evaluated, and biomarker measurements will help better understand mechanisms of action. The trial is funded by the French Ministry of Health, the European Society of Anaesthesiology, and Sedana Medical." @default.
- W4280553695 created "2022-05-22" @default.
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- W4280553695 date "2022-05-16" @default.
- W4280553695 modified "2023-09-25" @default.
- W4280553695 title "Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial" @default.
- W4280553695 cites W1537972189 @default.
- W4280553695 cites W1563821170 @default.
- W4280553695 cites W1620542608 @default.
- W4280553695 cites W1789068835 @default.
- W4280553695 cites W1803784511 @default.
- W4280553695 cites W1850725243 @default.
- W4280553695 cites W1898928487 @default.
- W4280553695 cites W1921068641 @default.
- W4280553695 cites W1975239624 @default.
- W4280553695 cites W1982796470 @default.
- W4280553695 cites W1983945149 @default.
- W4280553695 cites W1988163197 @default.
- W4280553695 cites W1990639292 @default.
- W4280553695 cites W1990771406 @default.
- W4280553695 cites W2000492133 @default.
- W4280553695 cites W2006093551 @default.
- W4280553695 cites W2007473062 @default.
- W4280553695 cites W2021163726 @default.
- W4280553695 cites W2024224130 @default.
- W4280553695 cites W2024383876 @default.
- W4280553695 cites W2026274122 @default.
- W4280553695 cites W2041441379 @default.
- W4280553695 cites W2089785792 @default.
- W4280553695 cites W2094922717 @default.
- W4280553695 cites W2106923828 @default.
- W4280553695 cites W2107146794 @default.
- W4280553695 cites W2109616324 @default.
- W4280553695 cites W2109704422 @default.
- W4280553695 cites W2113620519 @default.
- W4280553695 cites W2115186092 @default.
- W4280553695 cites W2139146091 @default.
- W4280553695 cites W2170892587 @default.
- W4280553695 cites W2174616275 @default.
- W4280553695 cites W2289115148 @default.
- W4280553695 cites W2311680441 @default.
- W4280553695 cites W2314787815 @default.
- W4280553695 cites W2322956032 @default.
- W4280553695 cites W2333411966 @default.
- W4280553695 cites W2339338165 @default.
- W4280553695 cites W2463645864 @default.
- W4280553695 cites W2512780017 @default.
- W4280553695 cites W2515625652 @default.
- W4280553695 cites W2534521479 @default.
- W4280553695 cites W2555737777 @default.
- W4280553695 cites W2576939111 @default.
- W4280553695 cites W2597070792 @default.
- W4280553695 cites W2610582798 @default.
- W4280553695 cites W2618861551 @default.
- W4280553695 cites W2620241325 @default.
- W4280553695 cites W2754594065 @default.
- W4280553695 cites W2775900594 @default.
- W4280553695 cites W2885896746 @default.
- W4280553695 cites W2889601329 @default.
- W4280553695 cites W2904268023 @default.
- W4280553695 cites W2912354430 @default.
- W4280553695 cites W2944755457 @default.
- W4280553695 cites W2966043734 @default.
- W4280553695 cites W3035808329 @default.
- W4280553695 cites W3037217621 @default.
- W4280553695 cites W3091916594 @default.
- W4280553695 cites W3096001562 @default.
- W4280553695 cites W3097093266 @default.
- W4280553695 cites W3099389154 @default.
- W4280553695 cites W3100556260 @default.
- W4280553695 cites W3103593121 @default.
- W4280553695 cites W3155950045 @default.
- W4280553695 cites W3170855480 @default.
- W4280553695 cites W3195497415 @default.
- W4280553695 cites W4211250103 @default.