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- W4280554172 abstract "Hypohidrotic ectodermal dysplasia (HED) is a rare hereditary disease characterized by hypoplasia of tissues derived from the ectoderm, such as hair, teeth, and sweat glands. There have been no reports of oral cancer in HED patients. Here, we report a case of multiple oral cancers in a patient with HED. A 24-year-old woman with HED visited our hospital for oligodontia-associated dental treatment. During follow-up, metachronous squamous cell carcinoma occurred in the left maxillary gingiva and right mandibular gingiva. Although surgery and chemoradiation were performed, the cancer progressed to unresectable cervical lymph node metastasis. Cetuximab-based therapy was selected as the subsequent anticancer therapy, and administered for 11 months. Because the patient developed sick sinus syndrome, which is an unlikely side effect of cetuximab, anticancer therapy could not be continued. The patient eventually died at 36 years old. We concluded that careful follow-up focusing on possibility of early onset of oral cancer is required, and cetuximab can be a treatment option for cancers in patients with HED." @default.
- W4280554172 created "2022-05-22" @default.
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- W4280554172 date "2022-11-01" @default.
- W4280554172 modified "2023-09-25" @default.
- W4280554172 title "A case of multiple oral cancers in the patient with hypohidrotic ectodermal dysplasia" @default.
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- W4280554172 doi "https://doi.org/10.1016/j.ajoms.2022.04.008" @default.
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