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• W4280554970 abstract "Background & Aim Hydrogen sulfide (H2S) plays a protective role in non-alcoholic fatty liver disease (NAFLD). However, whether cystathionine gamma lyase (CSE), a dominant H2S generating enzyme in hepatocytes, has a role in the pathogenesis of NAFLD is currently unclear. Approach & Results We showed that CSE protein expression is dramatically down-regulated, especially in fibrotic areas, in livers from NAFLD patients. In high fat diet (HFD)-induced NAFLD mice, or an oleic acid-induced hepatocyte model, the CSE/H2S pathway is also down-regulated. To illustrate a regulatory role for CSE in NAFLD, we generated a hepatocyte-specific CSE knockout mouse (CSELKO). Feeding a HFD to CSELKO mice, they showed more hepatic lipid deposition with increased activity of the fatty acid de-novo synthesis pathway, increased hepatic insulin resistance and higher hepatic gluconeogenic ability, compared to CSELoxp control mice. By contrast, H2S donor treatment attenuated these phenotypes. Furthermore, the protection conferred by H2S was blocked by Farnesoid X receptor (FXR) knockdown. Consistently, serum deoxycholic acid and lithocholic acid (FXR antagonists) were increased, and tauro-β-muricholic acid (FXR activation elevated) was reduced in CSELKO. CSE/H2S promoted a novel post-translation modification (sulfhydration) of FXR at Cys138/141 sites, thereby enhancing its activity to modulate expression of target genes related to lipid and glucose metabolism, inflammation, and fibrosis. Sulfhydration proteomics in patient’s liver supported the CSE/H2S modulation noted in the CSELKO mice. Conclusion FXR-sulfhydration is a novel post-translational modification affected by hepatic endogenous CSE/H2S that may promote FXR activity and attenuate NAFLD. Hepatic CSE deficiency promotes development of non-alcoholic steatohepatitis. The interaction between H2S and FXR may be amenable to therapeutic drug treatment in NAFLD." @default.
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• W4280554970 date "2022-06-30" @default.
• W4280554970 modified "2023-10-16" @default.
• W4280554970 title "Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor" @default.
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• W4280554970 doi "https://doi.org/10.1002/hep.32577" @default.
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