Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280559527> ?p ?o ?g. }
- W4280559527 endingPage "977" @default.
- W4280559527 startingPage "961" @default.
- W4280559527 abstract "Introduction: The goal of this study was to see if ascorbic acid grafted polylactic glycolic acid-b-polyethylene glycol nanoparticles (PLGA-b-PEG NPs) might boost the carrying or transport capacity of rivastigmine (RSM) to the brain via choroid plexus Sodium-dependent vitamin C transporter 2 (SVCT2 transporters). The IR and 1H NMR, were used to characterise the PLGA-b-PEG copolymer. Methods: Nanoprecipitation method was used to make PLGA-b-PEG NPs. To promote SVCT2-mediated transportation of ascorbic acid (Asc) into the brain, PLGA-b-PEG NPs of acceptable size, polydispersity, and drug loading were bound with ascorbic acid (PLGA-b-PEG-Asc). When compared to PLGA-b-mPEG NPs, the surface functionalization of NPs with ascorbic acid dramatically improved cellular uptake of NPs in SVCT2 expressing NIH/3T3 cells. Radial Arm Maze Test, and Acetylcholinesterase (AChE) activity in scopolamine-induced amnetic rats were used to assess in vivo pharmacodynamic effectiveness. Result: In vivo pharmacodynamic tests revealed that drug loaded PLGA-b-PEG-Asc NPs had much greater therapeutic and sustained activity than free drugs, and PLGA-b-mPEG NPs to the brain. Conclusion: As a consequence, the findings revealed that using ascorbic acid grafted PLGA-b-PEG NPs to deliver bioactives to the brain is a potential strategy." @default.
- W4280559527 created "2022-05-22" @default.
- W4280559527 creator A5012583046 @default.
- W4280559527 creator A5018608533 @default.
- W4280559527 date "2023-08-01" @default.
- W4280559527 modified "2023-10-16" @default.
- W4280559527 title "An In vivo Investigation of Ascorbic Acid Tethered Polymeric Nanoparticles for Effectual Brain Transport of Rivastigmine" @default.
- W4280559527 cites W1970720197 @default.
- W4280559527 cites W1972219849 @default.
- W4280559527 cites W1973602321 @default.
- W4280559527 cites W1974890503 @default.
- W4280559527 cites W1980632854 @default.
- W4280559527 cites W1981320103 @default.
- W4280559527 cites W1988279007 @default.
- W4280559527 cites W1999794509 @default.
- W4280559527 cites W2015921952 @default.
- W4280559527 cites W2016070833 @default.
- W4280559527 cites W2035558311 @default.
- W4280559527 cites W2038375609 @default.
- W4280559527 cites W2046511622 @default.
- W4280559527 cites W2047313630 @default.
- W4280559527 cites W2047414721 @default.
- W4280559527 cites W2047687145 @default.
- W4280559527 cites W2053972194 @default.
- W4280559527 cites W2054546290 @default.
- W4280559527 cites W2056315056 @default.
- W4280559527 cites W2058012429 @default.
- W4280559527 cites W2064736787 @default.
- W4280559527 cites W2065302847 @default.
- W4280559527 cites W2066616213 @default.
- W4280559527 cites W2067671461 @default.
- W4280559527 cites W2069298530 @default.
- W4280559527 cites W2076255406 @default.
- W4280559527 cites W2077134890 @default.
- W4280559527 cites W2078724751 @default.
- W4280559527 cites W2081586642 @default.
- W4280559527 cites W2081698238 @default.
- W4280559527 cites W2085907924 @default.
- W4280559527 cites W2093346123 @default.
- W4280559527 cites W2097545575 @default.
- W4280559527 cites W2104977898 @default.
- W4280559527 cites W2108791885 @default.
- W4280559527 cites W2120569491 @default.
- W4280559527 cites W2134099103 @default.
- W4280559527 cites W2167258371 @default.
- W4280559527 cites W2167924652 @default.
- W4280559527 cites W2228668600 @default.
- W4280559527 cites W2261085470 @default.
- W4280559527 cites W2511654038 @default.
- W4280559527 cites W2753082054 @default.
- W4280559527 cites W2794092880 @default.
- W4280559527 cites W2886328984 @default.
- W4280559527 cites W2919187857 @default.
- W4280559527 cites W2920901214 @default.
- W4280559527 cites W2965717703 @default.
- W4280559527 cites W2998545905 @default.
- W4280559527 cites W3015140168 @default.
- W4280559527 cites W3034784818 @default.
- W4280559527 cites W3048616070 @default.
- W4280559527 cites W3080887171 @default.
- W4280559527 cites W3112777140 @default.
- W4280559527 cites W3117380154 @default.
- W4280559527 cites W3130760084 @default.
- W4280559527 cites W3159530706 @default.
- W4280559527 doi "https://doi.org/10.2174/1567201819666220516093425" @default.
- W4280559527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35578875" @default.
- W4280559527 hasPublicationYear "2023" @default.
- W4280559527 type Work @default.
- W4280559527 citedByCount "0" @default.
- W4280559527 crossrefType "journal-article" @default.
- W4280559527 hasAuthorship W4280559527A5012583046 @default.
- W4280559527 hasAuthorship W4280559527A5018608533 @default.
- W4280559527 hasConcept C10138342 @default.
- W4280559527 hasConcept C150903083 @default.
- W4280559527 hasConcept C162324750 @default.
- W4280559527 hasConcept C185592680 @default.
- W4280559527 hasConcept C202751555 @default.
- W4280559527 hasConcept C207001950 @default.
- W4280559527 hasConcept C2776964284 @default.
- W4280559527 hasConcept C2780165375 @default.
- W4280559527 hasConcept C2986274086 @default.
- W4280559527 hasConcept C31903555 @default.
- W4280559527 hasConcept C54400483 @default.
- W4280559527 hasConcept C55493867 @default.
- W4280559527 hasConcept C71924100 @default.
- W4280559527 hasConcept C86803240 @default.
- W4280559527 hasConcept C98274493 @default.
- W4280559527 hasConceptScore W4280559527C10138342 @default.
- W4280559527 hasConceptScore W4280559527C150903083 @default.
- W4280559527 hasConceptScore W4280559527C162324750 @default.
- W4280559527 hasConceptScore W4280559527C185592680 @default.
- W4280559527 hasConceptScore W4280559527C202751555 @default.
- W4280559527 hasConceptScore W4280559527C207001950 @default.
- W4280559527 hasConceptScore W4280559527C2776964284 @default.
- W4280559527 hasConceptScore W4280559527C2780165375 @default.
- W4280559527 hasConceptScore W4280559527C2986274086 @default.
- W4280559527 hasConceptScore W4280559527C31903555 @default.
- W4280559527 hasConceptScore W4280559527C54400483 @default.