Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280560055> ?p ?o ?g. }
- W4280560055 endingPage "136428" @default.
- W4280560055 startingPage "136428" @default.
- W4280560055 abstract "Immune checkpoint inhibitors-based cancer immunotherapy is yielding great clinical benefit, but its efficacy is limited in gastric cancer (GC) by the lack of T-cell infiltration in the tumor microenvironment. Notably, activating the DNA-sensitive cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS/STING) signaling pathway could trigger innate immunity and recruitment of tumor-infiltrating lymphocytes. Herein, we constructed co-loaded platinum nanoparticles (Pt-NPs; chemo-prodrugs) and IR820 (photosensitizer) into hollow mesoporous organosilica nanoparticles (termed as [email protected]/Pt-NPs). The [email protected]/Pt-NPs exhibit appropriate size distribution, good biocompatibility, and generate reactive oxygen species under mild near infrared irradiation (0.7 W cm−2). Importantly, [email protected]/Pt-NPs efficiently enter GC cells and release loaded drugs. Pt-NPs can trigger H2O2 decomposition to O2, enhancing photodynamic efficiency. Furthermore, IR820 could enter into mitochondria, then induce mitochondria oxidative stress disorder, resulting in the releasing of oxidative mitochondrial DNA (mitoDNA). Meanwhile, this oxidative process also allowed for oxidation of Pt(0) to cytotoxic Pt(II), resulting in the dysfunction of nuclear DNA (nDNA). Dual-damage to nDNA and mitoDNA activates the c-GAS/STING pathway, stimulating innate immunity, including a primary anti-tumor effect and recruitment of CD8+ T cells, enhancing cross-presentation inside dendritic cells, and sustaining lethality in distant tumors. In summary, [email protected]/Pt-NPs have the potential to improve immunotherapy efficacy in GC." @default.
- W4280560055 created "2022-05-22" @default.
- W4280560055 creator A5004792778 @default.
- W4280560055 creator A5006104645 @default.
- W4280560055 creator A5036475045 @default.
- W4280560055 creator A5038560506 @default.
- W4280560055 creator A5039572116 @default.
- W4280560055 creator A5059143011 @default.
- W4280560055 creator A5068242405 @default.
- W4280560055 creator A5088947934 @default.
- W4280560055 date "2022-09-01" @default.
- W4280560055 modified "2023-10-16" @default.
- W4280560055 title "Improved immunotherapy for gastric cancer by nanocomposites with capability of triggering Dual-Damage of Nuclear/Mitochondrial DNA and cGAS/STING-Mediated innate immunity" @default.
- W4280560055 cites W1544249031 @default.
- W4280560055 cites W1650754258 @default.
- W4280560055 cites W1875373156 @default.
- W4280560055 cites W1940241680 @default.
- W4280560055 cites W1974693247 @default.
- W4280560055 cites W1980885456 @default.
- W4280560055 cites W1996830477 @default.
- W4280560055 cites W2016318035 @default.
- W4280560055 cites W2022724942 @default.
- W4280560055 cites W2028107828 @default.
- W4280560055 cites W2033448006 @default.
- W4280560055 cites W2040913240 @default.
- W4280560055 cites W2092943609 @default.
- W4280560055 cites W2141037581 @default.
- W4280560055 cites W2154171253 @default.
- W4280560055 cites W2287250785 @default.
- W4280560055 cites W2516126003 @default.
- W4280560055 cites W2522054472 @default.
- W4280560055 cites W2537321298 @default.
- W4280560055 cites W2622499649 @default.
- W4280560055 cites W2769703207 @default.
- W4280560055 cites W2787524634 @default.
- W4280560055 cites W2793364080 @default.
- W4280560055 cites W2909301717 @default.
- W4280560055 cites W2920686366 @default.
- W4280560055 cites W2921875691 @default.
- W4280560055 cites W2938774982 @default.
- W4280560055 cites W2943668434 @default.
- W4280560055 cites W2945605368 @default.
- W4280560055 cites W2947304693 @default.
- W4280560055 cites W2947862269 @default.
- W4280560055 cites W2954264125 @default.
- W4280560055 cites W2972409835 @default.
- W4280560055 cites W2974443571 @default.
- W4280560055 cites W2985757611 @default.
- W4280560055 cites W2995171541 @default.
- W4280560055 cites W3012207340 @default.
- W4280560055 cites W3020803474 @default.
- W4280560055 cites W3031702735 @default.
- W4280560055 cites W3036927511 @default.
- W4280560055 cites W3042355687 @default.
- W4280560055 cites W3042580206 @default.
- W4280560055 cites W3046038934 @default.
- W4280560055 cites W3083958325 @default.
- W4280560055 cites W3090091286 @default.
- W4280560055 cites W3092748143 @default.
- W4280560055 cites W3093008524 @default.
- W4280560055 cites W3096521890 @default.
- W4280560055 cites W3107280407 @default.
- W4280560055 cites W3109382696 @default.
- W4280560055 cites W3118507078 @default.
- W4280560055 cites W3119005666 @default.
- W4280560055 cites W3133659109 @default.
- W4280560055 cites W3137643713 @default.
- W4280560055 cites W3139352227 @default.
- W4280560055 cites W3154403008 @default.
- W4280560055 cites W3171517418 @default.
- W4280560055 cites W3184139646 @default.
- W4280560055 cites W3208310917 @default.
- W4280560055 doi "https://doi.org/10.1016/j.cej.2022.136428" @default.
- W4280560055 hasPublicationYear "2022" @default.
- W4280560055 type Work @default.
- W4280560055 citedByCount "12" @default.
- W4280560055 countsByYear W42805600552022 @default.
- W4280560055 countsByYear W42805600552023 @default.
- W4280560055 crossrefType "journal-article" @default.
- W4280560055 hasAuthorship W4280560055A5004792778 @default.
- W4280560055 hasAuthorship W4280560055A5006104645 @default.
- W4280560055 hasAuthorship W4280560055A5036475045 @default.
- W4280560055 hasAuthorship W4280560055A5038560506 @default.
- W4280560055 hasAuthorship W4280560055A5039572116 @default.
- W4280560055 hasAuthorship W4280560055A5059143011 @default.
- W4280560055 hasAuthorship W4280560055A5068242405 @default.
- W4280560055 hasAuthorship W4280560055A5088947934 @default.
- W4280560055 hasConcept C121608353 @default.
- W4280560055 hasConcept C136449434 @default.
- W4280560055 hasConcept C143425029 @default.
- W4280560055 hasConcept C167672396 @default.
- W4280560055 hasConcept C185592680 @default.
- W4280560055 hasConcept C203014093 @default.
- W4280560055 hasConcept C2776107976 @default.
- W4280560055 hasConcept C2777701055 @default.
- W4280560055 hasConcept C2780674031 @default.
- W4280560055 hasConcept C28859421 @default.
- W4280560055 hasConcept C48349386 @default.