Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280565548> ?p ?o ?g. }
- W4280565548 abstract "Summary Crosstalk between Rho- and Arf-family GTPases plays an important role in linking actin cytoskeletal remodeling to membrane protrusion, organelle structure, and vesicle trafficking. The central actin regulator, WAVE Regulatory Complex (WRC), is a converging point of Rac1 (a Rho-family GTPase) and Arf signaling in many processes, but how Arf promotes WRC activation is unknown. Here we reconstituted a direct interaction between Arf and WRC. This interaction can be greatly enhanced by Rac1 binding to the D site of the WRC. Arf1 binds to a newly identified conserved surface on Sra1 located between the D site and the WH2 helix of WAVE1, which can drive WRC activation using a mechanism distinct from that of Rac1. Mutating Arf binding site abolishes Arf1-WRC interaction, disrupts Arf1-mediated WRC activation, and impairs lamellipodia morphology. This work uncovers a new mechanism underlying WRC activation and provides a mechanistic foundation for studying how WRC-mediated actin polymerization links Arf and Rac signaling in the cell." @default.
- W4280565548 created "2022-05-22" @default.
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- W4280565548 date "2022-05-13" @default.
- W4280565548 modified "2023-09-26" @default.
- W4280565548 title "Arf GTPase activates the WAVE Regulatory Complex through a novel binding site" @default.
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- W4280565548 doi "https://doi.org/10.1101/2022.05.13.491857" @default.
- W4280565548 hasPublicationYear "2022" @default.
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