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- W4280567939 abstract "Abstract Generally, successful testis transplantation has been considered to require immune suppression in the recipient to avoid rejection of the transplanted tissue. In the present study, we demonstrate in medaka that allogeneic adult testicular tissue will engraft in adult recipients immediately after partial castration without the use of immunosuppressive drugs. The allografted testes are retained in the recipient’s body for at least three months and are able to produce viable sperm that yield offspring after natural mating. Some recipients showed a high frequency (over 60%) of offspring derived from spermatozoa produced by the transplanted testicular tissue. Histological analyses showed that allografted testicular tissues included both germ cells and somatic cells that had established within an immunocompetent recipient testis. The relative simplicity of this testis transplantation approach will benefit investigations of the basic processes of reproductive immunology and will improve the technique of gonadal tissue transplantation." @default.
- W4280567939 created "2022-05-22" @default.
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- W4280567939 date "2022-05-08" @default.
- W4280567939 modified "2023-10-01" @default.
- W4280567939 title "Allogeneic testes transplanted into partially castrated adult medaka (<i>Oryzias latipes</i>) can produce donor-derived offspring by natural mating over a prolonged period" @default.
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- W4280567939 doi "https://doi.org/10.1101/2022.05.07.490875" @default.
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